Human Leukocyte Antigen News and Research

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HSE researchers discover genetic predisposition to COVID-19 severity

HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology.

23 Feb 2021

Study explains why people of African descent are less likely to find bone marrow donors

A paper by a multidisciplinary team of scientists affiliated with various Brazilian institutions, including the University of São Paulo (USP) and the National Cancer Institute (INCA), shows that people of African descent are less likely to find a donor in the National Register of Voluntary Bone Marrow Donors (REDOME) than people with predominantly European ancestry.

1 Feb 2021

Anakinra shows therapeutic potential in critically ill COVID-19 patients

A team of international scientists recently conducted an open-level clinical trial to investigate the effects of personalized immunotherapy on critically ill COVID-19 patients.

27 Jan 2021

SARS-CoV-2 mutations may evade T cell immunity

A potentially disturbing new study suggests that SARS-CoV-2 may be undergoing strategic mutations that affect the host immune capacity to recognize and combat the pathogen via T effector cells.

23 Dec 2020

Epitope “megapools” could help determine role T cell immunity plays in COVID-19

Researchers in the United States and Australia have conducted a comprehensive analysis of the epitope recognition patterns associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans.

14 Dec 2020

Reverse phenotyping shows reactive T cell profiles in SARS-CoV-2 infection

A new study appearing as a preprint on the medRxiv* browser in December 2020 employs reverse phenotyping technology to explore T cell responses in COVID-19.

10 Dec 2020

BCG vaccination appears to trigger cross-reactive SARS-CoV-2-specific T cell response

Recently, researchers from the Monash University and Monash Medical Centre, Clayton, Victoria, Australia, investigated whether peptide sensitization using BCG can produce cross-reactive T cells specific to SARS-CoV-2. Their study is published on the preprint server, medRxiv.

24 Nov 2020

Lonza provides expansive selection of high-resolution HLA-typed primary cells to boost drug development

Lonza has announced that it now provides an expansive selection of high-resolution Human Leukocyte Antigen (HLA)-typed primary cells spanning all major cell and tissue types.

From Lonza 20 Nov 2020

Exciting findings on CD8 T cell response in recovered COVID patients

An international team of scientists has identified novel T cell-recognized epitopes spanning different proteins of severe acute respiratory syndrome coronavirus 2 in COVID-19 recovered patients. The scientists have also revealed phenotypical characteristics of the T cell population.

11 Oct 2020

New findings could improve investigation of T cell response to COVID-19

Researchers in the United States have made an important discovery about the processing and presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral peptides that provides a better understanding of the immune response to coronavirus disease 2019 (COVID-19) and may help facilitate the design of improved vaccines.

5 Oct 2020

Neo-self antibody could be a major cause of recurrent pregnancy loss

A research group centered around Kobe University Graduate School of Medicine's Professor YAMADA Hideto and Associate Professor TANIMURA Kenji (Department of Obstetrics and Gynecology), and Professor ARASE Hisashi et al. of Osaka University's Research Institute for Microbial Diseases (RIMD) have revealed for the first time in the world the high frequency of a novel autoantibody in women suffering from recurrent pregnancy loss.

23 Jul 2020

Berkeley Lights announces Opto™ antigen-presenting bead kit to accelerate the expansion of antigen-specific T cells used to develop cell-based therapies

Berkeley Lights, Inc. today announced the Opto Antigen-Presenting Bead kit, a new reagent kit that activates and expands antigen-specific T cells in blood.

From Bruker Cellular Analysis 25 Jun 2020

Researchers investigate possible causes of high COVID-19 mortality in Italy

On March 11th, 2020 the World Health Organization declared Coronavirus disease (COVID-19) a pandemic.

29 May 2020

New Thermo Scientific Proteome Discoverer 2.5 software strengthens laboratory workflows

Scientists in the life sciences can now benefit from upgrades to a suite of analytical software solutions with new features designed to enhance productivity, confidence and accuracy in numerous fields, including proteomics, food safety and biotherapeutic drug development.

From Thermo Fisher Scientific Inc. 28 May 2020

Study provides genetic explanation behind the sex bias observed in certain diseases

Some diseases exhibit a clear sex bias, occurring more often, hitting harder or eliciting different symptoms in men or women.

12 May 2020

Study shows COVID-19 vulnerability is highly dependent on host genetic architecture

A new US study available on the preprint server medRxiv reveals certain genetic variations that are associated with infection susceptibility and diverse clinical presentation of coronavirus disease (COVID-19) – including asymptomatic cases and severe forms of the disease in younger patients.

10 May 2020

Mapping complex peripheral immune response to severe COVID-19

In a recent article publicly available at medRxiv, researchers from Stanford have presented a single-cell atlas of the peripheral immune response to coronavirus disease (COVID-19), highlighting pertinent immunological features associated with the severe forms of the disease.

26 Apr 2020

Researchers discover new way to refine production of retinal cells to treat blindness

Researchers at Karolinska Institutet and St Erik Eye Hospital in Sweden have discovered a way to refine the production of retinal cells from embryonic stem cells for treating blindness in the elderly.

30 Mar 2020

Microbiome could help identify pre-cancer risk in women with HPV

A new study published in the open-access journal PLOS Pathogens in March 2020 reports the possible use of the bacteria Gardnerella found in the cervix and vagina of women with Human papillomavirus (HPV) infection, as a marker of precancerous change. The findings could help to find new methods of treatment that involve inducing changes in the microbiome to arrest the course of the disease.

26 Mar 2020

Comprehensive tumor profiling reveals why osteosarcoma does not respond to immunotherapy

Comprehensive profiling of tumor samples taken from patients with osteosarcoma shows that multiple factors contribute to the traditionally poor responses observed from treatment with immune checkpoint inhibitors, according to new research from The University of Texas MD Anderson Cancer Center.

22 Feb 2020