Ibuprofen News and Research

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Ibuprofen is a drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

Surgeons can avoid postoperative opioid prescriptions, studies suggest

Surgeons can ease their patients' pain from common operations without prescribing opioids, and avoid the possibility of starting someone on a path to long-term use, a pair of new studies suggests.

10 Jun 2021

Chemical engineers devise a simpler process to incorporate hydrophobic drugs into tablets

About 60 percent of drugs on the market have hydrophobic molecules as their active ingredients. These drugs, which are not soluble in water, can be difficult to formulate into tablets because they need to be broken down into very small crystals in order to be absorbed by the human body.

8 Jun 2021

Scientists propose new strategies to find drugs that neutralize critical enzymes

Scientists from the University of Bath explore racemases and propose strategies for finding drugs that target these important enzymes.

26 May 2021

Are COVID-19 medications safe in pregnancy?

Most medications being tested today in clinical trials for the treatment of coronavirus disease 2019 (COVID-19) have been repurposed from other indications. These are typically not tested in pregnant women. A new study, published in the journal PLOS ONE, summarizes what is known about the safety of these drugs in this group.

24 May 2021

New peptides allow cannabis-derived drugs to fight pain in mice without side effects

An international team, led by researchers from Pompeu Fabra University (UPF) in Barcelona, Spain, David Andreu and Rafael Maldonado, has developed a peptides family that allows delta-9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, to fight pain in mice without side effects.

20 May 2021

Many adults with hypertension may be taking other medications that could raise blood pressure

Nearly 1 in 5 adults with high blood pressure, a leading risk factor for heart disease and stroke, also take a medicine that could be elevating their blood pressure, according to new research presented at the American College of Cardiology's 70th Annual Scientific Session.

6 May 2021

Study finds higher risk of overdose in patients treated with opioids to reduce dental pain

When they go to the dentist to get a tooth pulled or another procedure, patients might not think that the prescription they receive to ease their pain could put them or their family at risk of an opioid overdose.

29 Apr 2021

Some COX inhibitors/NSAIDs increase COVID-19 severity

A startling new preprint research paper posted to the medRxiv server warns against the use of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the category of cyclooxygenase inhibitors (COX inhibitors) in patients with coronavirus disease 2019 (COVID-19).

22 Apr 2021

Long-term, regular use of baby aspirin may reduce risk of colorectal cancer death

Long-term, regular use of baby aspirin-;at least 15 times per month-;prior to a diagnosis of colorectal cancer (CRC) may reduce the risk of death from the disease by limiting the spread of cancerous tumors pre-diagnosis, according to a study led by Cedars-Sinai Cancer researchers.

29 Mar 2021

Antidepressants provide no important benefits for managing low back pain

A new systematic review led by UNSW Sydney has found that treating low back pain with antidepressant medicines provides no important benefits and has the potential to cause harm.

8 Mar 2021

Post-surgery opioid prescribing guideline leads to high patient satisfaction with pain management

A prescribing guideline tailored to patients' specific needs reduced the number of opioid pills prescribed after major surgery with researchers reporting a greater than 90 percent patient satisfaction rate with pain management and the highest compliance rate to date with appropriate disposal of leftover pills.

25 Feb 2021

Genetically engineered cartilage delivers anti-inflammatory drug in response to knee activity

Working to develop new treatments for osteoarthritis, researchers at Washington University School of Medicine in St. Louis have genetically engineered cartilage to deliver an anti-inflammatory drug in response to activity similar to the bending of a knee or other motions that put stress on joints.

27 Jan 2021

Specific NSAIDs are metabolized by acyl-CoA synthetases leading to liver toxicity

Liver injury is a rare side effect of nonsteroidal anti-inflammatory drugs (NSAIDs), which are frequently used for daily pain control.

22 Jan 2021

Antidepressants are not effective for treating back pain, osteoarthritis, shows study

Antidepressants are commonly used worldwide to treat pain, however new research from the University of Sydney shows they offer little to no help for people suffering chronic back pain and osteoarthritis and may even cause harm.

20 Jan 2021

OU Health Sciences Center receives federal grant for opioid management in older adults

Chronic pain can be quite common among older adults as they face conditions such as arthritis and neuropathy. Treating pain in older adults requires special considerations, however, especially when it comes to opioids.

8 Dec 2020

Poisoning exposures appear to be increasing in Australian schools

New research from the University of Sydney has found poisoning exposures in children and adolescents while at school are relatively common and appear to be increasing, highlighting the need for more robust prevention measures.

3 Nov 2020

Researchers observe a rapid drop in average body temperature in tropical human population

In the nearly two centuries since German physician Carl Wunderlich established 98.6°F as the standard "normal" body temperature, it has been used by parents and doctors alike as the measure by which fevers -- and often the severity of illness -- have been assessed.

29 Oct 2020