Immunotoxin News and Research

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Selective immunotoxins may help treat liver fibrosis

Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen.

12 Jul 2021

Delivering split immunotoxins separately to cancer cells can reduce life-threatening side effects

Splitting one type of cancer drug in half and delivering the pieces separately to cancer cells could reduce life-threatening side effects and protect healthy, non-cancerous cells, a new study suggests.

25 Aug 2020

Researchers target cancer's protective barrier

Cancer cells are notorious for their camouflage work, which enables them to escape immune targeting. Now scientists are learning how to strip away the disguise and allow the immune system to do its work, by targeting cells called myeloid-derived suppressor cells (MDSCs) that shield the tumor. This would also enhance the effectiveness of newer cancer immunotherapies like Chimeric-Antigen Receptor T cell (CAR-T).

26 Aug 2019

New immunotoxin found to be safe, effective in patients with B-cell malignancies

Almost all patients with a group of blood cancers called B-cell malignancies have two prominent "fingerprints" on the surface of leukemia and lymphoma cancers, called CD22 and CD19, Vallera explained.

13 Mar 2015

Researchers show how bacteria responsible for strep throat can be used to fight colon cancer

Researchers at Western University (London, Canada) have shown how the bacteria primarily responsible for causing strep throat can be used to fight colon cancer. By engineering a streptococcal bacterial toxin to attach itself to tumour cells, they are forcing the immune system to recognize and attack the cancer.

21 May 2014

Study: HIV-specific poison kills persisting HIV-infected cells during antiretroviral therapy

A team including University of North Carolina and NIH scientists has demonstrated in a mouse model that an HIV-specific poison can kill cells in which the virus is actively reproducing despite antiretroviral therapy.

10 Jan 2014

Gene transfer technique eliminates specific neural circuit linked to Parkinson's disease

In the brains of humans and non-human primates, over 100 billion nerve cells build up complicated neural circuits and produce higher brain functions. When an attempt is made to perform gene therapy for neurological diseases like Parkinson's disease, it is necessary to specify a responsible neural circuit out of many complicated circuits.

27 Jun 2012

MedImmune to present data on oncology portfolio at two medical congresses in Europe and the U.S.

Today, MedImmune announced that researchers will present data from its oncology portfolio, including new clinical data, at two upcoming medical congresses in Europe and the United States.

17 Nov 2010

Immunomedics reports on ribonuclease-based immunotoxin development at AACR meeting

Immunomedics, Inc., a biopharmaceutical company focused on developing monoclonal antibodies to treat cancer and other serious diseases, today reported results from two studies on the development of ribonuclease-based immunotoxins at the American Association for Cancer Research conference.

22 Apr 2010

MedImmune to present ten abstracts at American Association for Cancer Research meeting

MedImmune today announced that ten abstracts on progress being made in various oncology programs will be presented during the Annual Meeting of the American Association for Cancer Research in Washington, DC from April 17 to 21.

17 Apr 2010

Immunomedics' progress in cancer therapy product candidates to be presented at AACR 2010

Immunomedics, Inc., a biopharmaceutical company focused on developing monoclonal antibodies to treat cancer and other serious diseases, today announced that eight presentations reporting on the Company's progress in diverse cancer therapy product candidates will be given at the 101st Annual Meeting of the American Association for Cancer Research, April 17 – 21, 2010, in Washington, DC.

13 Apr 2010

Scott & White's CRI launches two clinical trials targeting cancers

Scott & White's Cancer Research Institute (CRI) has launched two clinical trials targeting cancers that affect both adults and children.

6 Jan 2010

Novel anti-inflammatory therapy protects lungs from runaway inflammation

A novel anti-inflammatory therapy designed by Vanderbilt University Medical Center investigators prevents acute lung injury in mice exposed to an inflammation-causing toxin, the researchers report in the journal Molecular Therapy.

11 Mar 2009

Computational research hones cancer-fighting strategies

A Florida State University faculty member who uses computational techniques to evaluate a new class of cancer-killing drugs is attracting worldwide attention from other researchers.

3 Jul 2008

Immunomedics presents results on novel immunotoxin for prostate and lung cancers

Immunomedics has presented at the 2007 Annual Meeting of the American Association for Cancer Research results on the in vitro and in vivo evaluation of a novel immunotoxin, Rap-hRS7, for the potential treatment of prostate and lung cancers.

18 Apr 2007

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

Duke University researchers have now shown that selectively killing the population of regulatory T cells in cancer patients - cells that normally function to restrain the activity of the immune response - improves the ability of a cancer vaccine to stimulate tumor-specific T cells.

28 Nov 2005

Effective treatment for soft tissue sarcoma (rhabdomyosarcoma)

Rhabdomyosarcoma is a highly malignant aggressive form of soft tissue cancer in children, the causes of which are currently unknown. Although the fibrous growths can be found all over the body they commonly develop around the head, neck, bladder and testes in young boys.

15 Jul 2004