Effective treatment for soft tissue sarcoma (rhabdomyosarcoma)

NewsGuard 100/100 Score

Rhabdomyosarcoma is a highly malignant aggressive form of soft tissue cancer in children, the causes of which are currently unknown. Although the fibrous growths can be found all over the body they commonly develop around the head, neck, bladder and testes in young boys.

The most common age for onset is between 1-5 years of age. The treatments used are usually chemotherapy using a combination of drugs, radiotherapy and surgery and although quite effective (66% success rate at present), the side affects commonly experienced by the young patients are very unpleasant and the whole process can prove to be very traumatic not only for the patient but for the families too. So there is a need for a better way of treating the disease.

At present the cocktail of drugs administered through the chemotherapy route are not selective to the cancer cells and so they also attack healthy cells. In order for the treatment to be effective without causing unnecessary tissue damage, researchers have been looking for ways to specifically target the cancer cells in order to deliver the therapeutic agent that will kill the tumour.

An unexpected link between rhabdomyosarcoma and a particular form of a disease known as myasthenia gravis was recently discovered by University scientists. Research was being carried out at the University of Oxford amongst women suffering from spontaneous miscarriages caused by an autoimmune response to their own foetus. It was then discovered that the mothers were producing antibodies against a molecule on the surface of the foetal cells which was the same as that present on the surface of the rhabdomyosarcoma cells. Scientists at the University of Würzburg then made molecules that were smaller fragments of the antibody but which would still have the same attraction for the rhabdomyosarcoma cells as for the original antibody. A gene that encodes the fragments was then transferred into a bacteria containing the DNA for a toxin. An immunotoxin was then produced containing the antibody fragment and the toxin together which is able to target the sarcoma cells using the antibody fragment and kill them with the toxin.

The immunotoxin has already been tested in a good model system and the positive results achieved have been able to show the therapeutic potential of the technique. The antibody fragment is also able to carry other toxins or even radioactive elements such as Yttrium for delivery to the site of a tumour.

Dr Richard Middleton, the project manager from Isis Innovation Ltd, the technology transfer company for the University of Oxford stated, “This is excellent science leading to an application which may be of real benefit to people in an area of currently unmet need”.

http://www.isis-innovation.com

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Study links air pollution to increased colorectal cancer risk through DNA changes