In Utero News and Research

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Immunogenicity of insect-specific Zika virus-vectorized vaccine candidates

The immunogenicity, safety, and effectiveness of ARPV/ZIKV a chimeric insect-specific flavivirus (ISFV)-Zika vaccine.

17 Nov 2023

Maternal distress during pregnancy linked to mental health risk and behavior problems in children

Children whose mothers are highly stressed, anxious or depressed during pregnancy may be at higher risk for mental health and behavior issues during their childhood and teen years, according to research published by the American Psychological Association.

16 Nov 2023

Maternal metabolic conditions linked to children's neurodevelopmental risks, study shows

Study investigates how maternal metabolic conditions like pregestational diabetes, gestational diabetes, and obesity mediate the risk of neurodevelopmental conditions in children. It highlights the significant role of obstetric and neonatal complications in this relationship, emphasizing the need for managing these complications to mitigate children's risk of developing conditions like ADHD and autism.

12 Nov 2023

New digital atlas reveals detailed stages of human fetal brain maturation

A comprehensive digital atlas of fetal brain maturation from a large cohort.

31 Oct 2023

Does the timing of prenatal exposure to corticosteroids and β2-agonists impact a child's neurodevelopment by age 3?

Researchers investigated the association between the timing of in-utero exposure to β2-agonists and corticosteroids and offspring neurodevelopmental milestones during the initial three years of life.

26 Oct 2023

Study challenges link between low birth weight and childhood neurodevelopmental issues

A recent study in JAMA Psychiatry used Mendelian Randomization to examine the link between low birth weight and neurodevelopmental issues in children. The research found no causal relationship between maternal genetic factors affecting birth weight and offspring neurodevelopment, although some evidence suggested that fetal genetic variants may play a limited role.

25 Oct 2023

New study links prenatal chemical exposure to childhood obesity trajectories

Connections between prenatal exposure to endocrine-disrupting chemicals and the growth patterns of children's BMI.

20 Oct 2023

Mothers' psychosocial stress during pregnancy has negative associations with children's sleep

Study shows that mothers' psychosocial stress during pregnancy has negative associations with their children's sleep that persist across childhood.

28 Sep 2023

New software uncovers that myelin develops much slower after birth

A single brain is unfathomably complex. So brain researchers, whether they're looking at datasets built from 300,000 neurons in 81 mice or from MRIs of 1,200 young adults, are now dealing with so much information that they must also come up with new methods to comprehend it.

22 Sep 2023

Placental examination can accurately determine cause of 90% of unexplained pregnancy losses

Yale researchers have shown that placental examination resulted in the accurate pathologic determination of more than 90% of previously unexplained pregnancy losses, a discovery that they say may inform pregnancy care going forward.

19 Sep 2023

Human post-implantation embryo models show promise in unraveling early development

Researchers evaluate post-implantation development in humans using embryo-like models based on genetically unmodified human naïve embryonic stem cells.

12 Sep 2023

Skin signals neurons to grow the appropriate endings

Nerve cells that sense touch grow the appropriate endings for hairy or hairless skin based on cues from the skin itself, rather than through predetermined programming, according to research led by Harvard Medical School scientists and published Aug. 21 in Developmental Cell.

23 Aug 2023

Lead exposure in early life may increase risk of adult criminality

An evaluation of 17 previously published studies suggests that exposure to lead in the womb or in childhood is associated with an increased risk of engaging in criminal behavior in adulthood-;but more evidence is needed to strengthen understanding.

1 Aug 2023

Cadmium exposure disrupts placental hormones, harming fetal development

As with many toxins, exposure to the toxic metal cadmium during pregnancy can adversely impact fetal development.

28 Jul 2023

MU researcher receives $3 million grant to use gene editing for investigating the building blocks of disease

In a new study funded by a $3 million grant from the National Institutes of Health (NIH), University of Missouri researcher Kiho Lee, an associate professor in the College of Agriculture, Food and Natural Resources, will use gene editing to investigate the building blocks of disease.

27 Jul 2023

Fetal exposure to epilepsy medications does not affect neurodevelopment in children

Most mothers who took prescription antiseizure medications during pregnancy can breathe a sigh of relief: A new study published today in Lancet Neurology found that young children who were exposed to commonly-prescribed medications in utero do not have worse neurodevelopmental outcomes than children of healthy women.

19 Jul 2023

Predicting kidney abnormalities in utero with deep learning

Researchers examine the potential use of deep learning models to diagnose fetal kidney anomalies.

17 Jul 2023

U-M researchers develop animal-free method to produce brain organoids

Researchers at University of Michigan developed a method to produce artificially grown miniature brains -; called human brain organoids -; free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated.

13 Jul 2023

Non-invasive technique can help identify infants at high risk for retinopathy of prematurity

Research from Ann & Robert H. Lurie Children's Hospital of Chicago promises to spare many premature infants from undergoing invasive eye exams to detect retinopathy of prematurity (ROP), the most common cause of preventable lifelong blindness in children in the U.S.

29 Jun 2023

Research explains mechanisms behind anti-viral protection in hemochorial placentas

Give credit to your dad's gene for keeping you safe during those long months in your mother's womb.

20 Jun 2023