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Study reveals how SARS-CoV-2 hijacks lung cells to drive COVID-19 severity

Researchers identified how SARS-CoV-2 targets and manipulates specific lung cells, using innovative techniques to trace the virus's impact on the cells' gene expression, revealing insights into early COVID-19 pathogenesis.

14 Apr 2024

Study reveals unexpected vulnerability of lung immune cells to SARS-CoV-2

The lung-cell type that's most susceptible to infection by SARS-CoV-2, the virus that causes COVID-19, is not the one previously assumed to be most vulnerable.

10 Apr 2024

Examining the cardiac pathology in fatal cases of yellow fever

The characteristics of yellow fever (YF)-related myocardial damage.

28 Sep 2023

HER2-TPMC proves to be a reasonable alternative for HER2-positive cancer chemotherapeutics

Announcing a new article publication for BIO Integration journal. Antibody-drug conjugates (ADCs) have the following advantages: target specificity; wide therapeutic index; and prolonged circulation half-life.

15 May 2023

Study explores histopathological, serological, and clinical characteristics of PASC in patients with mild COVID-19

Researchers investigated the clinical, histopathological, imaging, and serological characteristics of post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in patients with mild COVID-19.

5 Dec 2022

Study explores cell signaling dysregulation and COVID-19 severity

Researchers assessed the impact of dysregulation in cell signaling events on coronavirus disease 2019 (COVID-19) severity.

12 Oct 2022

Nitazoxanide shows promise for COVID-19 treatment in animal model

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that Nitazoxanide (NTZ), an oral drug, broadly inhibits replication of several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in preclinical models of infection.

13 Feb 2022

Study suggests myeloid cell dysregulation is a driver of COVID-19 severity

Researchers determine the driving factors for disease severity and death due to COVID-19.

17 Jan 2022

Highly neutralizing human convalescent plasma reduces lung inflammation in SARS-CoV-2-infected macaques

A new study reignites the debate regarding the therapeutic utility of convalescent plasma in treating others with the COVID-19.

7 Sep 2021

Role of neutrophil-epithelial interactions in SARS-CoV-2 infection

Researchers discuss the relationship between airway neutrophils and SARS-CoV-2 infection to determine the impact that neutrophils have on COVID-19.

15 Aug 2021

Wearable sensor shows link between blood pressure and intracranial pressure

Brazilian researchers have simultaneously demonstrated the mechanism linking high blood pressure to elevated intracranial pressure, validated a non-invasive intracranial pressure monitoring method, and proposed a treatment for high blood pressure that does not affect intracranial hypertension.

8 Jun 2021

Researchers identify key genetic changes in interstitial kidney tissue of people with diabetes

Researchers from Indiana University have identified key genetic changes in the interstitial kidney tissue of people with diabetes, a discovery that signifies the potential for a revolutionary new genetic approach to the treatment of kidney disease.

16 Feb 2021

Researchers describe cellular mediator that makes muscle adaptation to exercise possible

The onset of any physical exercise program causes muscle pain that can hinder movements as simple as getting up from a sofa. With time and a little persistence, the muscles become accustomed to the effort, developing more strength and endurance.

1 Dec 2020

Cerebrospinal fluid may play underappreciated role in both good health and response to injury

Swelling is one of the most dangerous and immediate consequences of a brain injury or stroke. Doctors have long known about the dangers of swelling, which has traditionally been blamed on ruptured blood vessels.

24 Nov 2020

Vitamin C and COVID-19: A Review

In a recent review published in Preprints*, Patrick Holford et al. address vitamin C's role as adjunctive therapy for respiratory infection, sepsis, and COVID-19.

23 Oct 2020

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

As the COVID-19 pandemic progresses with little prospect of immediate relief, a recent study by Johns Hopkins University researchers published on the preprint server medRxiv* in October 2020 discusses the association of Immunoglobulin M (IgM) autoantibodies against the host receptor that binds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with severe disease via vascular endothelial damage. This could help develop better therapies and prognostic criteria.

19 Oct 2020

Researchers detect significant amounts of DNA traps in lungs of deceased Covid-19 patients

A multidisciplinary team of researchers from the University of Liège (Belgium) has detected significant amounts of DNA traps in distinct compartments of the lungs of patients who died from Covid-19.

15 Sep 2020

3D bioengineered model could reveal new treatments for deadly lung disease

A 3D bioengineered model of lung tissue built by University of Michigan researchers is poking holes in decades worth of flat, Petri dish observations into how the deadly disease pulmonary fibrosis progresses.

14 Sep 2020

Mouse model of fatal COVID-19 developed for vaccine and drug testing

Now, a new study published on the preprint server bioRxiv in July 2020 presents an engineered transgenic mouse that reproduces the functional and clinical characteristics of severe human SARS-CoV-2 infection.

21 Jul 2020

Groundbreaking study identifies unique lung cells that may drive pulmonary fibrosis

A groundbreaking study published today and led by the Translational Genomics Research Institute, an affiliate of City of Hope, identifies unique lung cells that may drive Idiopathic Pulmonary Fibrosis, a deadly lung disease that affects hundreds of thousands of Americans, and for which there is no cure.

9 Jul 2020