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UCSB neuroscientist provides new understanding of how the brain uses perception to guide action

A UC Santa Barbara researcher studying how the brain uses perception of the environment to guide action has a new understanding of the neural circuits responsible for transforming sensation into movement.

9 Sep 2016

Novel Trojan Horse antibody strategy may target Ebola's Achilles' heel

In research published online today in Science, a team of scientists describe a new therapeutic strategy to target a hidden Achilles' heel shared by all known types of Ebola virus.

8 Sep 2016

University of Arizona could contribute to improved tumor assessment with preclinical PET scanner for simultaneous PET/MRI

Cubresa Inc., a medical imaging company that develops and markets molecular imaging systems, today announced the successful installation of their compact PET scanner called NuPET™ for preclinical PET (Positron Emission Tomography) and MRI (Magnetic Resonance Imaging) in the Department of Medical Imaging at the University of Arizona (UA).

From Cubresa Inc. 1 Sep 2016

Researchers discover new role of cellular signaling molecule involved in release of hunger hormone

Researchers at UT Southwestern Medical Center have identified a previously unknown role of a cellular signaling molecule involved in release of the "hunger hormone" ghrelin, a finding that could have implications for optimal treatment of children taking beta blockers.

23 Aug 2016

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Before I explain the discovery, I would take a step back and explain an interesting event that takes place in the cancer cells. Normal cells follow a rapid and irreversible process to efficiently eradicate dysfunctional cells. This is a natural process by which damaged cells commit ‘suicide’. This process is known as apoptosis or programmed cell death.

15 Aug 2016

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but proguanil, which is widely used for the prevention of malaria, does not.

12 Aug 2016

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

Research from investigators at Rutgers Cancer Institute of New Jersey and Princeton University has identified a new approach to cancer therapy in cutting off a cancer cell's 'fuel supply' by targeting a cellular survival mechanism known as autophagy.

11 Aug 2016

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

Therapeutic strategies targeting Alzheimer's disease (AD)-related molecule β-amyloid (Aβ), Tau protein and BACE enzyme have been recently explored. However the therapeutic efficacy for a single target is not ideal.

8 Aug 2016

UTA researchers find how changing estrogen levels make women more vulnerable to cocaine addiction

Researchers at The University of Texas at Arlington are studying how fluctuating estrogen levels make females increasingly sensitive to the rewarding effects of cocaine and ultimately, vulnerable to cocaine addiction.

2 Aug 2016

Researchers uncover novel virulence strategies employed by Leishmania parasite

Professor Albert Descoteaux of INRS-Institut Armand-Frappier Research Centre and his team have discovered novel virulence strategies employed by the Leishmania parasite.

29 Jul 2016

Human immune system proteins can help combat chlamydia infections

Scientists from Federal Research and Clinical Centre of Physical-Chemical Medicine, Koltzov Institute of Developmental Biology and MIPT have shown that peptidoglycan recognition proteins (PGLYRPs) of the human immune system can play a key role in the fight against chlamydia infections. Their study was published in Infection and Immunity.

28 Jul 2016

Scientists identify mutation responsible for new, rare genetic disorder

An international team of researchers has discovered the mutation responsible for a rare, newly identified genetic disorder that causes craniofacial abnormalities and developmental delays.

28 Jul 2016

Researchers identify genetic causes underlying higher rate of melanoma in men

A study led by researchers at Universitat Jaume I de Castellón has identified one of the genetic causes underlying the higher rate of melanoma in men. The results have been published in Biology of Sex Differences.

21 Jul 2016

Study develops new methodology to analyse genetic bases of pathogenic bacteria

The study has developed a pioneering methodology to analyse the genetic bases of pathogenic bacteria and can be used to identify therapeutic targets in order to develop new antimicrobial agents.

20 Jul 2016

Modifications to RUNX3 protein may promote cancer progression

Scientists from the Cancer Science Institute of Singapore at the National University of Singapore have discovered that modifications to a protein called RUNX3 may promote cancer progression.

18 Jul 2016

VIB research reveals new insights into ALS

Research into amyotrophic lateral sclerosis (ALS) conducted by VIB-KU Leuven has led to interesting and unexpected conclusions.

14 Jul 2016

Researchers reveal molecular mechanism of autophagy initiation

Researchers revealed that Atg13 links autophagy initiation factors to each other using a string-like conformation, thereby promoting the association of diverse elements of the autophagy initiation machinery, initiating autophagosome formation through the recruitment of Atg9 vesicles and phosphorylation of various Atg factors.

12 Jul 2016

Shire’s Xiidra receives FDA approval for treating dry eye disease in adult patients

Shire plc announces that the U.S. Food and Drug Administration has approved Xiidra (lifitegrast ophthalmic solution) 5%, a twice-daily eye drop solution indicated for the treatment of the signs and symptoms of dry eye disease in adult patients.

12 Jul 2016

Scientists discover new mechanism by which TNF protects against intracellular pathogens

Tumour necrosis factor (TNF), a messenger substance in the immune system, plays an important role in triggering chronic inflammatory diseases. For this reason, TNF inhibitors are a standard form of treatment for patients with rheumatoid arthritis and certain inflammatory bowel diseases.

11 Jul 2016

Researchers use FRET to make activation of AMPA receptors optically visible

Our brain is a high-performance computer. One of the key players in this complex system is the AMPA-type glutamate receptor. It ensures that neurotransmission proceeds at a breakneck pace from cell to cell.

6 Jul 2016