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Music can trigger cells to release insulin within minutes

Diabetes is a condition in which the body produces too little or no insulin. Diabetics thus depend on an external supply of this hormone via injection or pump.

22 Aug 2023

Researchers identify ion channel switches that regulate dopamine release in the brain

Researchers have identified two ion channel switches that regulate the release of dopamine in the brain, a first step that might one day lead to therapeutics for a wide range of diseases and disorders that currently have few solutions.

11 Aug 2023

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Study identifies gene fusions to understand their relationship with observed pathologies in cancer patients.

8 Aug 2023

Metrion Biosciences announces launch of Good Laboratory Practice (GLP) hERG Screening Service

Metrion Biosciences Limited, the specialist ion channel contract research and drug discovery company, today announced it has received notification from the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) that the Company is now a member of the UK GLP (Good Laboratory Practice) Compliance Monitoring Programme, and is, therefore, able to offer GLP compliant hERG ion channel screening services to the global life sciences community.

From Metrion Biosciences Limited 7 Aug 2023

Surprising new role for a key immune regulator revealed

A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

3 Aug 2023

Newly identified protein plays a key role in the action of emerging anticancer therapies

Scientists have identified a protein that plays a pivotal role in the action of several emerging cancer therapies. The researchers say the discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers.

31 Jul 2023

New gene therapy shows promise in reversing chronic pain

Researchers at NYU College of Dentistry's Pain Research Center have developed a gene therapy that treats chronic pain by indirectly regulating a specific sodium ion channel, according to a new study published in the Proceedings of the National Academy of Sciences.

27 Jul 2023

How the brain keeps blood sugar levels in check

The body's blood glucose level needs to be maintained in a relatively narrow range. It cannot be too high, as it can lead to diabetes, and it cannot be too low because it can cause fainting or even death.

11 Jul 2023

Metrion Biosciences expands senior leadership team with appointments of Dr Robert Kirby as COO and Dr Edward Stevens as CSO

Metrion Biosciences Limited (“Metrion”), is a specialist ion channel contract research and drug discovery company.

From Metrion Biosciences Limited 6 Jul 2023

New hope for cystic fibrosis patients as groundbreaking treatment enters clinical trial

Clinical testing is underway for a potentially groundbreaking new treatment for cystic fibrosis. Pioneered by scientists at Carle Illinois College of Medicine at the University of Illinois Urbana-Champaign and the Carver College of Medicine at the University of Iowa in partnership with the spin-out biotechnology company, cystetic Medicines, this promising inhalable molecular prosthetic is intended to improve lung function in people with CF who cannot benefit from current therapies.

26 Jun 2023

Metrion Biosciences appoints Dr Steve Jenkinson as VP, Drug Discovery and Safety Assessment to strengthen US operations

Metrion Biosciences Ltd (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced the appointment of Dr. Steve Jenkinson as Vice President, Drug Discovery and Safety Assessment. The US-based appointment represents an important step in the expansion of Metrion’s business, driven by its ion channel discovery capabilities.

From Metrion Biosciences Limited 12 Jun 2023

Study uncovers novel mechanisms underlying plant immunity against major root disease

Researchers led by CHEN Yuhang and ZHOU Jianmin from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have shown how plants resist clubroot, a major root disease that threatens the productivity of Brassica crops such as rape.

8 Jun 2023

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Over 2,800 cases, representing a 31% increase, added to BGI Genomics-led CardioGen's hereditary cardiovascular disease gene data.

From BGI Genomics 1 Jun 2023

Multiscale modeling and personalized therapies: tackling the complexities of epilepsy with degeneracy concept

Researchers described novel multiscale and population-level models for epilepsy.

9 May 2023

Researchers develop gene-edited stem cells to reduce arrhythmias in heart attack patients

In a recent study published in the journal Cell Stem Cell, researchers hypothesized that pacemaker-like activity of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) resulted in engraftment arrhythmias (EAs), which hampers the clinical use of cell-based therapy using hPSC-CMs for treatment of myocardial infarction (MI).

2 May 2023

How inert, sleeping bacteria spring back to life

Solving a riddle that has confounded biologists since bacterial spores -; inert, sleeping bacteria -; were first described more than 150 years ago, researchers at Harvard Medical School have discovered a new kind of cellular sensor that allows spores to detect the presence of nutrients in their environment and quickly spring back to life.

27 Apr 2023

Ion Channel News and Research

Music can trigger cells to release insulin within minutes

Researchers identify ion channel switches that regulate dopamine release in the brain

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Metrion Biosciences announces launch of Good Laboratory Practice (GLP) hERG Screening Service

Surprising new role for a key immune regulator revealed

Newly identified protein plays a key role in the action of emerging anticancer therapies

New gene therapy shows promise in reversing chronic pain

How the brain keeps blood sugar levels in check

Metrion Biosciences expands senior leadership team with appointments of Dr Robert Kirby as COO and Dr Edward Stevens as CSO

New hope for cystic fibrosis patients as groundbreaking treatment enters clinical trial

Metrion Biosciences appoints Dr Steve Jenkinson as VP, Drug Discovery and Safety Assessment to strengthen US operations

Study uncovers novel mechanisms underlying plant immunity against major root disease

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Multiscale modeling and personalized therapies: tackling the complexities of epilepsy with degeneracy concept

Researchers develop gene-edited stem cells to reduce arrhythmias in heart attack patients

How inert, sleeping bacteria spring back to life

UW researchers engineer stem cells that do not generate dangerous arrhythmias

Researchers elucidate how a single mutation causes episodic ataxia type 6

Molecular basis for alkaline taste discovered

Estrogen may increase the risk of certain types of arrhythmia

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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