Membrane Potential News and Research

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Research reveals how mitochondria keep their reactive oxygen species production in check

Mitochondria, the powerhouse of the cell, convert sustenance into energy, fueling the cell's activities. In addition to power, mitochondria also produce reactive oxygen species, byproduct molecules primed to help facilitate communication among the other units in the cells.

9 Jul 2021

Researchers develop the world's first digital cancer cell model

The computer model, developed under the lead management of researchers at TU Graz, simulates the cyclical changes in the membrane potential of a cancer cell using the example of human lung adenocarcinoma and opens up completely new avenues in cancer research.

1 Jul 2021

QurAlis gears up for clinical development of therapeutic candidate, QRL-101

(BUSINESS WIRE)--QurAlis Corporation, a biotech company developing breakthrough precision medicines for ALS and other genetically validated neurodegenerative diseases, today announced the publication of an article in Cell Reports.

9 Jun 2021

Combination of therapies may benefit patients with mitochondrial respiratory chain disorders

Researchers from the Mitochondrial Medicine Frontier Program at Children's Hospital of Philadelphia (CHOP) have demonstrated how one combination of therapies may be beneficial for patients with mitochondrial respiratory chain disorders.

3 Mar 2021

New molecular voltage sensor helps observe propagation of electrical signals in neurons

A type of novel molecular voltage sensor makes it possible to watch nerve cells at work. The principle of the method has been known for some time. However, researchers at the University of Bonn and the University of California in Los Angeles have now succeeded in significantly improving it.

4 Feb 2021

High-intensity workouts improve heart function, increase work capacity

High-intensity interval training strengthens the heart even more than moderate exercise does. Now researchers have found several answers to what makes hard workouts so effective.

11 Dec 2020

Research opens the possibility for new molecular probes and targeted drug delivery systems

Researchers at Kanazawa University monitored the emission of blue-green light from water-soluble tetraphenylethene molecules adsorbed at a phospholipid-adsorbed liquid-liquid interface made to resemble a biomembrane.

4 Nov 2020

Stanford researchers unravel how a common genetic deletion elevates schizophrenia risk

A common genetic deletion boosts the risk for schizophrenia by 30-fold. Generating nerve cells from people with the deletion has showed Stanford researchers why.

28 Sep 2020

Antibody-mediated platelet death linked to COVID-19 severity

A new study by University of Tuebingen researchers shows the strong association between platelet apoptosis and the thrombotic manifestations that may underlie critical COVID-19 illness.

7 Sep 2020

Bioluminescent molecule in fireflies shines light on mitochondrial activity

The mitochondria provide energy for our cells, yet their role in many diseases is still poorly understood. Thanks to a bioluminescent molecule, scientists at EPFL can observe them at work in living mammals.

10 Aug 2020

Harmful effects of BPA can be reversed by administering coenzyme Q10

Exposure to bisphenol A (BPA), an industrial chemical used to make certain plastics and resins, inner coatings for food cans and bottle tops, thermal paper used in store receipts, dental sealants and so on, is a concern because of possible adverse health effects, including a reduction in fertility.

7 May 2020

Study: Protein known to expand blood vessels works differently in males and females

A protein known to expand blood vessels -- key to controlling conditions like high blood pressure -- actually has different functions in males and females, new UC Davis Health research shows.

29 Apr 2020

New biochemical mechanism in cells is crucial component of anti-aging program

Aging is an inevitable part of life, yet some species are aging very differently than others, even than very similar ones.

11 Mar 2020

Light-activated protein restores mitochondrion function in fruit fly model of Parkinson’s disease

A light-sensitive protein can restore mitochondria function in fruit flies bearing a gene mutation associated with Parkinson’s disease and relieve its symptoms, report researchers at Juntendo University in the journal Communications Biology.

13 Feb 2020

Researchers identify control of a mitochondrial protective mechanism

Mitochondria are known as the "powerhouses" of cells. However, under critical pathophysiological conditions, they can use cellular energy for self-preservation.

12 Feb 2020

Novel drug can simultaneously help diagnose, treat gastric cancer

A novel drug, named "FerriIridium", can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is selectively activated only after reaching the interior of a tumor cell. This is possible because of the higher amount of iron present there, report scientists in the journal Angewandte Chemie.

23 Jan 2020

NIH-funded research finds differences in energy use by immune T cells in ME/CFS

New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions in the way they produce energy.

12 Dec 2019

Ultra-fast new technology to detect bacteria

A new detection method which can identify the presence of bacteria within a minute, while distinguishing healthy from non-viable bacteria, could save many lives and a lot of money. Scientists at the University of Warwick reported this technology, based on alterations in electrical signaling in bacteria in response to external electrical stimulation.

13 Jun 2019

Researchers investigate how antibiotic produced by the microbiome kills bacteria

A research team from the Universities of Tübingen and Göttingen as well as from the German Center for Infection Research has investigated the mode of action of a new class of antibiotics that is highly effective against multidrug-resistant pathogens.

4 Jun 2019

Nature-based antibiotic molecules for treatment of infections

New developments in antimicrobial peptides (AMPs) with antibiofilm properties are rapidly materializing.

2 Jan 2019