Mood Disorder News and Research

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Ketamine's rapid impact on depression linked to immune system pathways

Study reveals ketamine's potent anti-inflammatory effects on neurological disorders, showing promise for treating major depressive disorder through modulation of neuroimmune pathways.

15 Apr 2024

Diabetes drug dulaglutide may reduce symptoms of depression

The current study highlighted the antidepressant effects of dulaglutide using the CMS depression model. Notably, the potential metabolisms that underlie the antidepressant effect of dulaglutide have been elucidated in this study.

8 Mar 2024

Sleep-circadian disturbances can trigger or worsen a range of psychiatric disorders

Problems with our sleep and internal body clock can trigger or worsen a range of psychiatric disorders, according to a new review of recent research evidence.

19 Feb 2024

Study offers new insights into ketamine's rewiring of the brain

Ketamine – an anesthetic also known for its illicit use as a recreational drug – has undergone a thorough reputational rehabilitation in recent years as the medical establishment has begun to recognize its wide-ranging therapeutic effects.

4 Dec 2023

Study suggests concomitant antidepressant and statin use could prevent treatment discontinuation

A recent study in the journal BMC Medicine evaluates the real-world impact of combining antidepressants with statins in UK adults, revealing lower discontinuation rates but similar efficacy compared to antidepressant-only treatment.

12 Nov 2023

Can metabolic biomarkers help distinguish between depressive episodes of bipolar disorder and major depressive disorder?

Researchers identify metabolomic biomarkers from dried blood spots that can distinguish between depressive episodes in major depressive disorder and bipolar disorder. The study enhances diagnostic accuracy, particularly when traditional psychiatric assessments are inconclusive.

26 Oct 2023

Stress-induced ribosome dysregulation may underlie depression

A group of ribosomal protein genes connects animal models of depression to human patients with major depressive disorder.

10 Oct 2023

Researchers conduct comprehensive psychological evaluation of university students

The prevalence rates of stress, depression, anxiety, insomnia, mania, suicidal ideation, loneliness, and psychotic experiences among university-going students in the UK.

18 Sep 2023

Even in the most depressed county in America, stigma around mental illness persists

Sitting on a bench laughing with a co-worker during a morning smoke break, Debra Orcutt quickly raises her hand when asked if she knows anyone dealing with depression.

6 Sep 2023

Gut feeling: How your microbiome could be shaping your mental health

Researchers in Biological Psychiatry delve into the complex relationship between the gut microbiome and mental health disorders like depression and bipolar disorder. The study explores how not just gut bacteria, but also lesser-known gut microorganisms such as viruses, fungi, and parasites, play a pivotal role in mood disorders.

5 Sep 2023

Pregnant and postpartum women with mental health disorders more likely to use cannabis

Pregnant and recently postpartum women who suffer with mental health disorders may be vulnerable to using cannabis to self-medicate, according to a Rutgers-led study.

25 Aug 2023

Parents see own health spiral as their kids’ mental illnesses worsen

After her teenage daughter attempted suicide and began to cycle through emergency rooms and mental health programs during the past three years, Sarah Delarosa noticed her own health also declined.

14 Aug 2023

Unraveling the genetic code of bipolar disorder

Researchers investigate the genetic associations and heritability between categorical and dimensional bipolar disorder models.

14 Jul 2023

New category of depression identified

Scientists at Stanford Medicine conducted a study describing a new category of depression -; labeled the cognitive biotype -; which accounts for 27% of depressed patients and is not effectively treated by commonly prescribed antidepressants.

23 Jun 2023

Brexanolone inhibits key systemic inflammatory pathways associated with post-partum depression

Post-partum depression (PPD) develops after childbirth and affects both the mother's and the infant's health by preventing healthy bonding.

20 Feb 2023

Some antidepressants may be effective in treating chronic pain, but others lack effectiveness

New research has found some antidepressants may be effective in treating certain chronic pain conditions, but others lack convincing evidence on their effectiveness.

1 Feb 2023

Study highlights the importance of the gut microbiota during early neurodevelopment

A recent Brain, Behavior, and Immunity study investigated the role of the early-life gut microbiota in determining neurodevelopmental outcomes.

19 Dec 2022

Study finds higher mortality risk in patients with treatment resistant depression

Patients with treatment-resistant depression have a 23 per cent higher risk of death than other depressed patients. They also have twice as much outpatient care and spend three times the number of days in inpatient care.

15 Dec 2022

How a key brain network responds to seasonal shifts in day length

A recent paper examined the difference in neuronal communication in the hypothalamic network that regulates physiological function in response to the photoperiod.

8 Sep 2022

Parental depression screening could help identify families in need of mental health support

Screening both mothers and fathers for depression beyond their child's first birthday in pediatric offices – the current standard practice – could identify families in need of mental health and other critical resources, according to a Rutgers study.

28 Jun 2022