Nanoparticle News and Research

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In nanotechnology, a particle is defined as a small object that behaves as a whole unit in terms of its transport and properties. It is further classified according to size: in terms of diameter, fine particles cover a range between 100 and 2500 nanometers, while ultrafine particles, on the other hand, are sized between 1 and 100 nanometers.

Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid

Waiting a day or more to get lab results back from the doctor's office soon could become a thing of a past.

4 Dec 2006

Cytogen issued new patent covering oral drug delivery agents

Cytogen Corporation has announced that it has been issued United States patent number 7,135,457 covering its oral drug delivery agents - random peptide compositions that bind to gastro-intestinal tract (GIT) transport receptors.

28 Nov 2006

Nanotechnology continues to advance anticancer gene therapy

Given that cancer is a disease in which genetic errors play a major role, it should come as no surprise that many experts envision a time when gene therapy will play an equally important role in the treatment of cancer.

20 Nov 2006

Low-field magnetic separation of monodisperse Fe3O4 nanocrystals

Whether the goal is to separate different types of cells or molecules, methods that rely on the age-old principle of magnetism are a staple among researchers.

20 Nov 2006

Optical amplification of photothermal therapy with gold nanoparticles and nanoclusters

Gold nanoparticles, through their unique ability to convert light into heat, show great promise as miniature heaters capable of cooking cancer cells to death.

13 Nov 2006

Polymer coating improves tumor-targeting nanoparticles

Adding a thin coating of the biocompatible polymer poly(ethylene glycol) (PEG) to the surface of sulfur-modified, or thiolated, nanoparticles designed to fall apart inside tumors, prolongs the time that the resulting nanoparticles remain in tumors.

13 Nov 2006

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

In a dramatic demonstration of the power of nanotechnology, a team of investigators has designed a nanoscale, polymeric drug delivery vehicle that when loaded with a widely used anticancer agent cures colon cancer in mice with a single dose.

13 Nov 2006

Nanoparticle probes with surface enhanced Raman spectroscopic tags for cellular cancer targeting

Cancer biologists are always on the lookout for new methods of studying the effects that drug therapy has on malignant cells.

6 Nov 2006

Nanoparticles for two-photon photodynamic therapy in living cells

Photodynamic therapy (PDT) uses a combination of ultraviolet or visible light and a light-sensitive chemical, or photosensitizer, to kill cancer cells using reactive oxygen.

6 Nov 2006

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

In an attempt to create a single device that can image and treat tumors simultaneously, researchers at the University of Texas Southwestern Medical Center at Dallas have successfully melded magnetic iron nanoparticles, the anticancer drug doxorubicin, and a polymer tagged with a tumor-targeted molecule into a stable nanoparticle that accumulates inside human tumor cells.

6 Nov 2006

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

Though researchers have made substantial progress in developing drug-ferrying nanoparticles that successfully target tumor cells in living animals, including humans, investigators have only now started the detailed work needed to identify formulation parameters that would optimize drug delivery to malignant cells.

6 Nov 2006

Detecting rare microRNAs with gold nanoparticles

Over the past three years, numerous studies have shown that short pieces of single-stranded RNA, known as microRNAs, play a central role in the development of at least some cancers.

30 Oct 2006

Multifunctional composite nanoparticles: magnetic, luminescent, and mesoporous

Silica, the mineral of which sand is made, is generally inert in the body and can be modified easily using a variety of well-established chemical reactions.

30 Oct 2006

Self-assembling nanoparticle releases drug into cell cytoplasm

A growing body of research leaves no doubt that nanoparticles can transport drugs into cancer cells, but what is less clear is that the drug payload can exit the tiny endosomes that pull nanoparticles into cells.

30 Oct 2006

Multivalent effects of RGD peptides obtained by nanoparticle display

While a growing body of literature has shown that nanoparticle targeting can improve drug delivery and tumor imaging, there have been few systematic studies examining the net positive effect of nanoparticle targeting.

23 Oct 2006

Squalenoyl nanomedicines as potential therapeutics

Nucleoside analogs such as cytarabine and gemcitabine are powerful anticancer agents, but a simple chemical modification that causes them to assemble into stable nanoparticles could make them even more valuable in the treatment of a wide variety of cancers.

23 Oct 2006

New technique detects signature of metastasizing melanoma with as few as 10 cancer cells present in blood sample

Researchers at the University of Missouri-Columbia can now detect the spread of skin cancer cells through the blood by literally listening to their sound.

16 Oct 2006

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

Efforts to treat cancer using genes and other oligonucleotides, such as short interfering RNA (siRNA), that turn off the biochemical processes that trigger malignancies have been hindered by difficulties in delivering nucleic acids to tumors.

16 Oct 2006

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

The interactions between proteins and nucleic acids play a critical role in some of life’s most crucial biochemical processes, including gene expression and protein production, and some promising anticancer agents exert their effects by interfering with these interactions.

16 Oct 2006

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

One of the unusual properties of tumor cells is that their cell membranes are more fluid and less rigid than those of normal cells.

16 Oct 2006

Nanoparticle News and Research

Further Reading

Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid

Cytogen issued new patent covering oral drug delivery agents

Nanotechnology continues to advance anticancer gene therapy

Low-field magnetic separation of monodisperse Fe3O4 nanocrystals

Optical amplification of photothermal therapy with gold nanoparticles and nanoclusters

Polymer coating improves tumor-targeting nanoparticles

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

Nanoparticle probes with surface enhanced Raman spectroscopic tags for cellular cancer targeting

Nanoparticles for two-photon photodynamic therapy in living cells

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

Detecting rare microRNAs with gold nanoparticles

Multifunctional composite nanoparticles: magnetic, luminescent, and mesoporous

Self-assembling nanoparticle releases drug into cell cytoplasm

Multivalent effects of RGD peptides obtained by nanoparticle display

Squalenoyl nanomedicines as potential therapeutics

New technique detects signature of metastasizing melanoma with as few as 10 cancer cells present in blood sample

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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