Neuro oncology News and Research

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Major studies reveal improved treatment for children with Group 3 medulloblastoma

Vital research findings pointing to improved treatment for children with Group 3 medulloblastoma brain tumors have been revealed in two major studies published in the journal Neuro-Oncology.

9 Oct 2024

Innovative CAR-T cells effectively target glioblastoma with reduced toxicity

Glioblastoma is the most common and most aggressive primary brain tumor, with an average survival after diagnosis of less than two years, and against which current treatments remain ineffective.

26 Sep 2024

CDK4/6 inhibitors show promise for pediatric high-grade glioma treatment

CDK4/6 inhibitors, which are already FDA approved for the treatment of other forms of cancer, show early signs of promise in the treatment of a subtype of pediatric high-grade glioma, according to new research from Dana-Farber Cancer Institute and the Institute of Cancer Research in London.

3 Sep 2024

Drug shows new promise in treating breast cancer with brain metastases or recurrent glioblastoma

A drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio (UT Health San Antonio).

8 Aug 2024

Decoding glioblastoma: New insights into molecular subtypes and mesenchymal transition mechanisms

Glioblastoma multiforme (GBM) stands as a formidable adversary in oncology, characterized by its molecular complexity and relentless progression.

7 Aug 2024

FDA approves vorasidenib for Grade 2 gliomas with IDH mutations

Vorasidenib has been approved by the U.S. Food and Drug Administration (FDA) for patients with Grade 2 gliomas with IDH1 or IDH2 mutations.

6 Aug 2024

AI reprograms glioblastoma cells into dendritic cells for cancer immunotherapy

In an innovative new study of glioblastoma, scientists used artificial intelligence (AI) to reprogram cancer cells, converting them into dendritic cells (DCs), which can identify cancer cells and direct other immune cells to kill them.

31 Jul 2024

Study uncovers how OTX2 drives aggressive childhood brain cancer

In a report published in Nature Cell Biology, researchers at Baylor College of Medicine, Texas Children's Hospital, the University of Manitoba and collaborating institutions revealed an unexpected way in which the protein OTX2 drives the progression of medulloblastoma – the most common aggressive childhood brain cancer.

18 Jul 2024

Stem-like cells found to drive growth of aggressive pediatric brain tumors

A team of researchers at Baylor College of Medicine, Texas Children's Hospital, the Hospital for Sick Children in Toronto and collaborating institutions has identified and located a population of stem-like cells that initiates and maintains Group 3 medulloblastoma (Gr3-MB) in the developing brain.

9 Jul 2024

FDA expands orphan drug designation for Roswell Park's brain cancer immunotherapy

The U.S. Food and Drug Administration (FDA) has expanded orphan drug designation for SurVaxM, a brain cancer immunotherapy born in the labs of Roswell Park Comprehensive Cancer Center.

25 Jun 2024

Rapid test detects brain cancer mutations in cerebrospinal fluid

A test that looks for genetic hallmarks of brain cancers in samples of cerebrospinal fluid can decrease the time to diagnosis and eliminate the need for invasive brain biopsies for some patients.

17 Jun 2024

Ultrasound technology breaks blood-brain barrier for glioblastoma treatment

In a major advance for the treatment of the deadly brain cancer glioblastoma, Northwestern Medicine scientists used ultrasound technology to penetrate the blood-brain barrier and provide a small dose of a chemotherapy and immunotherapy drug cocktail.

6 Jun 2024

Stanford study reveals link between adaptive myelination and drug addiction

Our brains, even in adulthood, continually adapt to what we do, strengthening or weakening neural pathways as we practice new skills or abandon old habits.

5 Jun 2024

Unlocking glioblastoma's immune suppression mechanism

The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma -; a serious and often fatal brain cancer -; suppresses the immune system so that the tumor can grow unimpeded by the body's defenses.

3 May 2024

Epilepsy drug prevents brain tumor formation and growth in mouse models of NF1

A drug used to treat children with epilepsy prevents brain tumor formation and growth in two mouse models of neurofibromatosis type 1 (NF1), according to a study by researchers at Washington University School of Medicine in St. Louis.

15 Apr 2024

Revolutionizing brain tumor treatment: the rise of AI in neuro-oncology

The current state of knowledge about the role of artificial intelligence (AI) in the diagnosis, treatment, and prognosis of brain tumors.

2 Apr 2024

UC researchers open Phase 2 clinical trial to test new combination treatment for glioblastomas

A multidisciplinary team of University of Cincinnati Cancer Center researchers have opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas (GBM), the most deadly form of brain tumors.

26 Mar 2024

Innovative CAR T cell therapy targets two proteins to combat aggressive brain tumor growth

Breakthrough in Brain Cancer Treatment: Dual-Target CAR T Cell Therapy Shows Promise in Early Clinical Trial.

15 Mar 2024

Transformational $50 million gift from Kenneth C. Griffin to boost Sylvester's research footprint

The University of Miami today announced a transformational $50 million gift from Kenneth C. Griffin, Founder and Chief Executive Officer of Citadel and Founder of Griffin Catalyst, to Sylvester Comprehensive Cancer Center, part of the University of Miami Health System and the Miller School of Medicine.

6 Mar 2024