Organic chemistry News and Research

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New method of producing drug candidates may lead to better medicines in the future

A lot of our medicines and other bioactive drugs are based on chemical structures called "enantiomers"-- molecules that are mirror images of each other and are non-superimposable. Notable among them are chiral N,N-acetals contained in diuretic drugs like bendroflumethiazide and thiabutazide, used to treat high blood pressure and edema.

10 Feb 2021

New method can help evaluate potential sight-preserving properties

Scientists like the John A. Moran Eye Center's Paul S. Bernstein, MD, PhD, know a special class of lipids, or fatty acids, found in the retina of the eye and in just a few other parts of the body play an important role in maintaining vision.

5 Feb 2021

Scientists engineer potent trivalent inhibitors of thrombin

Thrombosis, the clogging of blood vessels, is a major cause of heart attacks and embolism. Scientists have now engineered the first inhibitors of thrombin, a protease promoting thrombosis, that is three-fold efficient.

29 Jan 2021

Stem cell based cell culture model to recapitulate important aspects of NAFLD

Nonalcoholic fatty liver disease (NAFLD) is a widespread condition in the Western World. Around 30% of the population have lipid droplets stored in their liver which diminish its function in the long term.

25 Jan 2021

Scientists grow insect sex pheromones in transgenic camelina plant for sustainable pest control

The camelina plant, a source of cooking oil for centuries, is on its way toward revolutionizing pest control in agriculture.

15 Jan 2021

Multidisciplinary research sheds new light on reaction mechanisms in cellular processes

Multidisciplinary research involving crystallography, kinetic studies, molecular docking, genetics and other techniques in biochemistry has yielded a wealth of knowledge about the reaction mechanisms in cellular processes.

1 Dec 2020

New analytical method to detect the patulin toxin in foods by using antibodies

The University of Valencia and Spanish National Research Council have patented a method to detect the patulin toxin in foods by using antibodies.

25 Nov 2020

Chemists discover effective inhibitors to block SARS-CoV-2

Some viruses can get inside cells via a mechanism that involves sulfur organic molecules. Chemists at UNIGE have discovered effective inhibitors and blocked the uptake of SARS-CoV-2.

20 Nov 2020

Scientists uncover new method to produce compounds with anti-cancer properties

In the past decades, cancer has surpassed many other diseases to become the current second leading cause of death globally, with one in six people dying from it.

17 Nov 2020

Study describes the effects of a DPP3-knockout on the renin-angiotensin system

The role of the enzyme dipeptidyl peptidase 3 in the blood pressure-regulating renin-angiotensin system was investigated in the inter-university cooperation project BioTechMed-Graz. The results could pave the way for new therapies for cardio-renal diseases.

5 Nov 2020

Scientists identify new target for developing novel drugs against several types of cancer

The Bcl-2 protein family comprises anti- and proapoptotic members, i.e. they protect the cell from death or favour it.

27 Oct 2020

New machine learning concepts can help develop novel drugs

Tandem mass spectrometry is a powerful analytical tool used to characterize complex mixtures in drug discovery and other fields.

14 Oct 2020

Chemists suggest a new domino reaction to produce organic compounds against cancers

A team of chemists from RUDN University suggested a new reaction to produce organic compounds in one vessel.

9 Oct 2020

DARPA selects Purdue-affiliated company to develop continuous manufacturing technology

The COVID-19 pandemic has created supply chain gaps in critical drug products, especially those needed for the most critical patients in intensive care units across the country.

7 Oct 2020

New book provides data about synthesis and relevant nucleophilic reactions for perhalopyridines

Halogenated pyridines can be used as interesting starting materials in a wide range of organic synthesis methods.

23 Sep 2020

DNA damage may occur far away from the point of incidence of radiation

Ultraviolet light endangers the integrity of human genetic information and may cause skin cancer. For the first time, researchers of Karlsruhe Institute of Technology have demonstrated that DNA damage may also occur far away from the point of incidence of the radiation.

14 Sep 2020

New bio-active natural products with huge potential as drugs

Natural compounds continue to play a key role in drug development. Many clinically approved drugs are either unmodified natural products or their semi-synthetic derivatives.

8 Sep 2020

UV researchers patent a kit to detect GHB in alcoholic beverages and soft drinks

The MODeLiC (Organic Materials for Controlled Detection and Release) research team led by Ana María Costero, Professor of Organic Chemistry at the University of Valencia (UV), has developed a system with colorimetric sensors that change color when there is γ-hydroxybutyric acid (GHB) in a beverage.

8 Sep 2020

FlowSyn system enables rapid evaluation of critical reactions

Uniqsis reports how a FlowSyn™ continuous flow reactor installed at Adesis Inc. of New Castle, DE (USA) is assisting them in evaluating custom synthetic routes for compounds along with improving existing batch manufacturing processes.

From Uniqsis Ltd 3 Sep 2020

Improved type of PROTAC enhances intracellular accumulation and protein knockdown

Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation.

27 Aug 2020