Pathophysiology News and Research

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Study demonstrates dynamic and broad-scale immune alterations in COVID-19 patient

A new case report released on the preprint server medRxiv* provides a detailed longitudinal analysis of the immune response associated with a fatal case of coronavirus disease (COVID-19). It highlights the need for addressing the source of hyper inflammation in the treatment approach.

10 May 2020

DFG to set up new clinical and research units

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is setting up three new Research Units and one new Clinical Research Unit.

7 May 2020

Multicolor Immunohistochemistry (IHC): Going Beyond a Single Color

An interview with Dr. Will Howat at SfN 2018, discussing the possibilities and challenges of immunohistochemistry (IHC) beyond a single color!

From Abcam 1 May 2020

French scientists suggest nicotinic agonists could treat COVID-19

Contrary to the warnings issued by health agencies worldwide against cigarette smoking amid the coronavirus disease (COVID-19), a new paper suggests the possibility that nicotine, a component of tobacco, could prevent coronavirus infection.

28 Apr 2020

Fraunhofer SCAI is opening a new knowledge space with information and analysis tools on COVID-19

With the new website "covid19-knowledgespace.de", Fraunhofer SCAI - together with Fraunhofer IME, Fraunhofer IAIS, the Information Center for Life Sciences ZBMED and other research partners - is opening a new kind of knowledge space with analysis tools and information on COVID-19.

24 Apr 2020

A new, potential treatment for nonalcoholic steatohepatitis with fibrosis

In the 2020 April 21 issue of Journal of Hepatology, a research group from the Department of Hepatology in Osaka City University Graduate School of Medicine, Japan reported that a new insight into the pathophysiology of human nonalcoholic steatohepatitis (NASH) with fibrosis and suggested a possibility of the new therapy using cytoglobin (CYGB) inducer for clinical application.

21 Apr 2020

Landmark 30-year study describes clinical course of patients with Crigler-Najjar syndrome

A new study summarizes more than 30 years of clinical experience and describes the clinical course of 28 individuals homozygous for damaging mutations in the UGT1A1 gene who were born between 1984 and 2015 with Crigler-Najjar syndrome.

17 Apr 2020

COVID-19 and type 2 diabetes have shared disease pathways, study finds

Individuals with diabetes are at increased risk for bacterial, parasitic and viral infections. New research published in Endocrine Reviews, a journal of the Endocrine Society, illuminates how intersections of the coronavirus infection (COVID-19) and type 2 diabetes may require new approaches in treatment for hospitalized patients.

15 Apr 2020

Chemists identify a drug to rescue winter depression-like behavior

A group of animal biologists and chemists at the Institute of Transformative Bio-Molecules, Nagoya University, has used a chemical genomics approach to explore the underlying mechanism of winter depression-like behavior and identified a drug that rescues winter depression-like behavior in medaka fish.

13 Apr 2020

Study sheds light on how a group of novel organelle-based disorders affects cells

A pioneering study has shed new light on how a group of novel organelle-based disorders affect cells.

10 Apr 2020

Bedroom air filters provide asthma relief for children

A new study by American and Chinese scientists, published in the journal JAMA Pediatrics, in April 2020, shows that a simple bedroom filter can help asthmatic children breathe better.

6 Apr 2020

Experts highlight the impact of COVID-19 pandemic on patients with Parkinson’s disease

While much attention has focused on the potential for severe respiratory complications and unfavorable outcomes from the COVID-19 pandemic among patients with Parkinson's disease (PD), the impact extends beyond these threats.

5 Apr 2020

Maintaining VDR levels in pancreatic cells could protect against diabetes

Maintaining vitamin D receptor levels in pancreatic cells that synthesize and secrete insulin could contribute to protecting against the development of diabetes and counteract pancreatic cell damage caused by the progression of the disease.

27 Mar 2020

Study suggests potential therapeutic strategy against diabetes

Maintaining vitamin D receptor levels in pancreatic cells that synthesize and secrete insulin (β cells) could contribute to protecting against the development of diabetes and counteract pancreatic cell damage caused by the progression of the disease.

26 Mar 2020

BIN1 deficit leads to impaired spatial learning and memory

Bridging integrator 1, known as BIN1, is the second most common risk factor for late-onset Alzheimer's disease, according to genome-wide studies of genetic variants. Yet, scientists know little about what this protein does in the brain.

11 Mar 2020

AI may help identify newborns at risk for aggressive posterior retinopathy of prematurity

An artificial intelligence device that has been fast-tracked for approval by the Food and Drug Administration may help identify newborns at risk for aggressive posterior retinopathy of prematurity.

4 Mar 2020

Chronic inflammation in pregnancy associated with neurodevelopmental delays in offspring

In pregnant women, obesity, diabetes, hypertension, depression and anxiety can increase the chances of learning delays, behavior problems and mental health issues in their children's early years.

25 Feb 2020

Scientists create world’s first model of pituitary disease using human iPS cells

Researchers at Kobe University's Graduate School of Medicine have developed the world's first congenital pituitary hypoplasia model using patient-derived iPS cells.

14 Feb 2020

Study tests hypothesis that empty SV40 capsids would improve sepsis outcomes

Numerous previous attempts to develop therapeutic treatments, directed at discreet targets of the sepsis cascade, could not cope with the complex pathophysiology of sepsis and failed.

13 Feb 2020

New book focuses on heart failure in pediatric patients

The field of heart failure in pediatric populations has recently initiated more registries and clinical trials. This age group has special concerns and particularities regarding their clinical picture and management. Therefore, multiple disciplines have been involved in the management of heart failure in this age group.

11 Feb 2020