Peripheral Neuropathy News and Research

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Peripheral neuropathy describes damage to the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body.

More than 100 types of peripheral neuropathy have been identified, each with its own characteristic set of symptoms, pattern of development, and prognosis. Impaired function and symptoms depend on the type of nerves -- motor, sensory, or autonomic -- that are damaged. Some people may experience temporary numbness, tingling, and pricking sensations, sensitivity to touch, or muscle weakness. Others may suffer more extreme symptoms, including burning pain (especially at night), muscle wasting, paralysis, or organ or gland dysfunction. Peripheral neuropathy may be either inherited or acquired. Causes of acquired peripheral neuropathy include physical injury (trauma) to a nerve, tumors, toxins, autoimmune responses, nutritional deficiencies, alcoholism, and vascular and metabolic disorders. Acquired peripheral neuropathies are caused by systemic disease, trauma from external agents, or infections or autoimmune disorders affecting nerve tissue. Inherited forms of peripheral neuropathy are caused by inborn mistakes in the genetic code or by new genetic mutations.

ReBuilder Medical Technologies secures license to manufacture electronic molluscum contagiosum treatment system

ReBuilder Medical Technologies, Inc. has announced that it has negotiated an exclusive license from White Hall, Inc. for the micronized, amorphous silver ion technology to treat the highly contagious skin disease, Molluscum Contagiosum.

28 Aug 2007

EpiCept to conduct Phase III study of EpiCept NP-1 for treatment of chemotherapy induced peripheral neuropathy

EpiCept Corporation has announced that it will study EpiCept NP-1, its patented topical cream formulation of two FDA-approved drugs, 4% amitriptyline and 2% ketamine, for the treatment of chemotherapy induced peripheral neuropathy (CPN) in the ATTRACT-CPN Phase III Study (Assessment of Topical Treatment Response with Amitriptyline and Ketamine: Combination Trial in Chemotherapy Peripheral Neuropathy).

23 Jul 2007

Scientists identify gene responsible for one type of Charcot-Marie-Tooth disorder

Scientists have identified the gene responsible for one type of Charcot-Marie-Tooth disorder, a common inherited neurological disease, thanks to the chance appearance of a strain of impaired 'pale tremor' mice in a University of Michigan research laboratory.

23 Jun 2007

Gene therapy provides hope for peripheral neuropathy

Researchers from the University of Pittsburgh School of Medicine report that they have successfully used gene therapy to block the pain response in an animal model of neuropathic pain, a type of chronic pain in people for which there are few effective treatments.

1 Jun 2007

Sangamo BioSciences starts phase 2 trial of therapy diabetic neuropathy

Sangamo BioSciences has announced that the company has initiated a repeat-dosing, multi-center Phase 2 clinical trial of SB-509 in subjects with moderate to severe diabetic peripheral sensory motor neuropathy (DN).

27 Apr 2007

Single master gene crucial for nerve cell insulation

Researchers funded by the National Institutes of Health have discovered how a defect in a single master gene disrupts the process by which several genes interact to create myelin, a fatty coating that covers nerve cells and increases the speed and reliability of their electrical signals.

17 Apr 2007

Federal agencies sued over medical Marijuana statements

The Oakland, Calif.-based advocacy group Americans for Safe Access on Wednesday filed suit in Oakland federal court against HHS and FDA over statements the organizations have made about medical marijuana, citing several studies that found the drug might benefit HIV-positive people, the Los Angeles Times reports.

25 Feb 2007

Marijuana gives relief from chronic pain for AIDS sufferers

Researchers have found that people suffering from chronic foot pain as a result of the AIDS virus gained relief from smoking marijuana.

14 Feb 2007

Tai chi tackles peripheral neuropathy

Peripheral neuropathy is a degenerative nerve disease with no cure and few effective treatment options - until now. Li Li, professor of kinesiology at LSU, is conducting a study into the benefits of tai chi for elderly peripheral neuropathy patients.

23 Jan 2007

Thalidomide, Lenalidomide show promise against Lou Gehrig's disease

New animal research suggests that two well-studied drugs, thalidomide and its derivative, lenalidomide, might extend the survival of patients with the neurological disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

9 Mar 2006

Early changes in the oxygenation of the skin may help predict foot disease in diabetes patients

Foot ulcerations are one of the most serious complications of diabetes, resulting in more than 80,000 lower-leg amputations each year in the U.S. alone.

14 Nov 2005

Study shows that nursing homes should consider diabetes a significant risk factor for falling

Falling is the leading cause of accidental death for elderly people, and a new study from Columbia University Medical Center and NewYork-Presbyterian Hospital/The Allen Pavilion suggests that nursing home residents with diabetes are four times more likely to fall than those who are not diabetic.

26 Sep 2005

Ruboxistaurin shows favorable effects on kidney damage and function in people with type 2 diabetes and nephropathy

Eli Lilly and Company today announced encouraging results from a one-year pilot study examining the effect of ruboxistaurin mesylate in persons with type 2 diabetes and kidney disease (also known as "diabetic nephropathy").

12 Jun 2005

Drug that reduces the pain of fibromyalgia and improves sleep

A study of a drug that reduces the pain of fibromyalgia and improves sleep is published by a University of Kentucky physician in the peer-reviewed journal, Arthritis & Rheumatism.

12 Apr 2005

Thalidomide - new treatment for cancer

Thalidomide, famous in the 60's because of limb deformities in babies born to women who had taken it for morning sickness, was withdrawn in 1961. Now doctors say it could be used as a treatment for cancer.

8 Mar 2005

Neuren and Metabolic collaborate to develop range of nerve repair compounds

Neuren Pharmaceuticals Ltd (Neuren) and Metabolic Pharmaceuticals Ltd (Metabolic) have announced that the two companies have agreed to collaborate to co-develop Neuren's class of Neuro-regenerative Peptides (NRPs) for the treatment of degenerative conditions such as peripheral neuropathy, motor neuron disease and repairing the brain or nerves after injuries such as spinal cord injury.

7 Mar 2005

Peripheral neuropathy in a patient with alcoholic cirrhosis is reversible

Organ damage that goes beyond the liver due to alcoholism is often seen as a barrier to liver transplantation, despite a lack of data on how a transplant affects these complications.

1 Dec 2004

Test used to diagnose B12 deficiency may be inadequate

A test that generally is used to measure the amount of vitamin B12 in the body is not sensitive enough to detect a deficiency of the vitamin, which has been linked to several neurological conditions, according to Saint Louis University research.

28 Oct 2004

Cymbalta significantly reduced pain in more than half of women treated for fibromyalgia, with and without major depression

The antidepressant Cymbalta (duloxetine HCl), a dual-reuptake inhibitor of serotonin and norepinephrine, 60 mg once or twice daily, significantly reduced pain in more than half of women treated for fibromyalgia, with and without major depression, according to 12-week data presented at the annual meeting of the American College of Rheumatology.

18 Oct 2004

Some patients who undergo treatment considered to be the last resort for severe obesity can develop peripheral neuropathy

Researchers from Mayo Clinic have found some patients who undergo a treatment considered to be the last resort for those who suffer from severe obesity - stomach stapling or gastric bypass surgery, can develop peripheral neuropathy, damage to the peripheral nerves, the vast communications network that transmits information from the brain and spinal cord to every other part of the body.

16 Oct 2004