How is Peripheral Neuropathy Treated?

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Medications for Treating Peripheral Neuropathy
Therapies for Treating Peripheral Neuropathy

Peripheral neuropathy is a condition in which damage occurs to the nerves of the peripheral nervous system, producing numbness, tingling, and pain.

Peripheral neuropathy can be caused by a large number of medical and environmental conditions: these include metabolic diseases such as diabetes; autoimmune diseases such as rheumatoid arthritis and lupus; cancerous growths that put pressure on surrounding nerve tissue; viral or bacterial infections such as shingles; medication toxicity induced by chemotherapeutic agents or other medications; exposure to environmental toxins such as pesticides; physical trauma resulting in nerve damage; repetitive motion disorders that compress surrounding nerves such as carpal tunnel syndrome; and excessive alcohol consumption.

Treatments for peripheral neuropathy can target the underlying cause of the nerve damage or the associated pain symptoms. Treatments include a variety of medications and therapies.

Peripheral Neuropathy

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Medications for Treating Peripheral Neuropathy

The pain associated with peripheral neuropathy, which can affect a patient’s emotional and physical well-being, can be managed through several medications.  Patients may take non-steroidal anti-inflammatory drugs (NSAIDs) or other over-the-counter analgesics in the earliest stages.  However, these medications are typically not effective for more severe pain.  In such cases, patients often find relief with anti-depressant or anti-epileptic medications, which interfere with pain detection mechanisms in the brain.

Patients suffering from peripheral neuropathy may also be given opioid-containing pain medications, but this is typically a last resort medication due to the high incidence of abuse and dependence associated with opioids.

A topical cream containing capsaicin is also available to alleviate pain symptoms.  Capsaicin is a naturally occurring substance found in chili peppers that blocks the pain sensation and provides additional relief to localized regions of the body.

For patients suffering from autoimmune-induced neuropathy, immunosuppressive drugs such as prednisone can limit additional damage to nerves.

Therapies for Treating Peripheral Neuropathy

When treating neuropathy, it is important to address the underlying cause of peripheral nerve damage. For example, the uncontrolled blood glucose levels found in patients with diabetes can damage the blood vessels that supply the peripheral nerves, resulting in diabetic neuropathy.

Diabetes is one of the most common causes of neuropathy, and proper management of glucose levels is imperative for patients with this condition to prevent further damage.

Similarly, patients with autoimmune disorders may undergo plasmapheresis, a therapy in which blood is removed from the body, filtered to remove antibodies and cells that trigger immune reactions, and returned to the body.

A variety of medical therapies are used to treat neuropathic symptoms. Transcutaneous electrical nerve stimulation (TENS) is a therapy used to alleviate pain symptoms.

TENS therapy uses electrodes and a gentle electrical current to stimulate nerve endings in areas where pain occurs, blocking pain sensations from reaching the brain.

TENS is often used in combination with medications or other therapy. Physical therapy is often used to help patients with muscle weakness regain strength and balance. Surgical therapy to relive nerve compression can be beneficial in some cases where localized damage occurs due to repetitive motion or injury.

There are also many lifestyle changes a patient can make to reduce existing symptoms or the potential for additional nerve damage. These include eating a healthy diet, stopping smoking, limiting alcohol consumption, and exercising regularly.

Exercise can strengthen muscles weakened by motor neuropathy and increase balance and coordination.

Smoking negatively affects the blood circulation supplying the nerves, and consuming alcohol exacerbates nerve damage. Frequent visual checks on the feet and hands can identify infections or abrasions that may go undetected due to lack of sensation.

TENS Therapy

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  • Peripheral neuropathy - Symptoms and causes. (2022). Retrieved 4 August 2022, from

  • Peripheral neuropathy . (2017). Retrieved 4 August 2022, from

  • Peripheral Neuropathy (2021). Available at: (Accessed: 4 August 2022).

Further Reading

Last Updated: Aug 4, 2022

Susan Chow

Written by

Susan Chow

Susan holds a Ph.D in cell and molecular biology from Dartmouth College in the United States and is also a certified editor in the life sciences (ELS). She worked in a diabetes research lab for many years before becoming a medical and scientific writer. Susan loves to write about all aspects of science and medicine but is particularly passionate about sharing advances in cancer therapies. Outside of work, Susan enjoys reading, spending time at the lake, and watching her sons play sports.


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