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Alternative splicing: a new approach to drug development? An interview with Lucy Donaldson

RNA is becoming an interesting drug target as it takes possible intervention back one step to the synthesis of a target protein, instead of trying to block or inhibit a process.

1 Feb 2016

FDA-approved blood pressure drug reduces cell damage linked to Alzheimer's disease

In laboratory neuronal cultures, an FDA-approved drug used to treat high blood pressure reduced cell damage often linked to Alzheimer's disease, say researchers at Georgetown University Medical Center and the National Institutes of Health.

30 Jan 2016

Sphingosine kinase inhibitor slows castration-resistant prostate cancer cell growth

A first-in-class sphingosine kinase 2 inhibitor slowed the growth of castration-resistant prostate cancer cells, in part by inhibiting the enzyme dihydroceramide desaturase (DEGS), but did not kill them, according to the results of preclinical in vitro and in vivo studies published in the December 2015 issue of Molecular Cancer Therapeutics by researchers at the Medical University of South Carolina and others.

30 Jan 2016

Certain viral infections during pregnancy could cause behavioral changes in offspring

A study published in the journal Science found that activation in pregnant mice of a particular immune response, similar to what may occur with certain viral infections during pregnancy, alters the brain structure of the mouse offspring and causes behavioral changes, reminiscent of those observed in humans with autism spectrum disorder (ASD).

30 Jan 2016

Vestibular test may aid ocular myasthenia gravis diagnosis

Assessing extraocular muscle activity by recording ocular vestibular evoked myogenic potentials is a promising test for isolated ocular myasthenia gravis, report researchers.

29 Jan 2016

Researchers develop new painkiller as strong as morphine but not addictive

Researchers at Tulane University and Southeast Louisiana Veterans Health Care System have developed a painkiller that is as strong as morphine but isn't likely to be addictive and with fewer side effects, according to a new study in the journal Neuropharmacology.

29 Jan 2016

Using centrifugal elutriation and flow cytometry to answer biological questions: an interview with Peter Lopez

Flow Cytometry, the measurement of various cellular characteristics as they flow through a measuring apparatus, has so many applications.

From Beckman Coulter Life Sciences - Centrifugation 27 Jan 2016

Nutrition and breast cancer; starving triple negative breast cancer cells to death: an interview with Associate Professor Jeff Holst

While there are a range of reports that different foods and food groups can increase or decrease your risk of cancer, these associations are very difficult to scientifically verify.

27 Jan 2016

Palonosetron effective anti-emetic for paediatric chemotherapy patients

Palonosetron 20 μg/kg is noninferior to ondansetron for the control of chemotherapy-induced vomiting and nausea during the acute phase of the first treatment cycle in paediatric patients with cancer, research shows.

26 Jan 2016

Neurons protect intestinal tissue from over-inflammation

The immune system exercises constant vigilance to protect the body from external threats--including what we eat and drink. A careful balancing act plays out as digested food travels through the intestine. Immune cells must remain alert to protect against harmful pathogens like Salmonella, but their activity also needs to be tempered since an overreaction can lead to too much inflammation and permanent tissue damage.

25 Jan 2016

Sunitinib versus everolimus trial highlights non-clear cell RCC patient response heterogeneity

Sunitinib offers significantly longer progression-free survival than everolimus for patients with metastatic non-clear cell renal cell carcinoma, phase II trial results indicate, but treatment effect appears to depend upon key patient characteristics.

22 Jan 2016

Swedish research group publishes scientific discoveries concerning EKC in Acta Ophthalmologica journal

A Swedish research group at St. Erik Eye Hospital, Stockholm, Karolinska Institutet, Solna, and Umeå University has published scientific discoveries concerning the serious infectious eye disease EKC in the prestigious journal Acta Ophthalmologica.

22 Jan 2016

Allergan announces publication of VIBERZI Phase III trial results in The New England Journal of Medicine

Allergan plc announced today the publication of the positive results of the Phase III trials of VIBERZITM C IV (eluxadoline) for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in the January 21 issue of The New England Journal of Medicine.

21 Jan 2016

Northwestern researchers use fruit fly genetics to understand how things may go wrong in cancer

Cancer cells are normal cells that go awry by making bad developmental decisions during their lives. In a study involving the fruit fly equivalent of an oncogene implicated in many human leukemias, Northwestern University researchers have gained insight into how developing cells normally switch to a restricted, or specialized, state and how that process might go wrong in cancer.

21 Jan 2016

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

Scientists have identified a gene that appears to play a significant role in raising a person's risk of having more severe subtypes of autism that co-occur with other genetic diseases, such as the chromosomal disorder 22q11.2 deletion syndrome.

20 Jan 2016

New study sheds light on possible role of ion channel in the immune system

Many cells have microscopic gates, called ion channels, which open to allow the flow of ions across the cell membrane. Thanks to these gates, cells can detect stimuli such as heat, pain, pressure and even spicy food.

20 Jan 2016

Estrogen helps women fight flu virus better than men

Estrogen dramatically reduced the amount of flu virus that replicated in infected cells from women but not from men, a new study by researchers at the Johns Hopkins Bloomberg School of Public Health shows.

20 Jan 2016

Selexipag reduces clinical events in PAH patients

Selexipag, alone or in combination with other classes of pulmonary arterial hypertension medication, reduced the composite rate of disease complications and deaths among patients in a phase III trial.

19 Jan 2016

TG4010 vaccine promising in advanced NSCLC

Addition of the TG4010 vaccine to first-line chemotherapy improves outcomes in patients with advanced non-small-cell lung cancer, show the results of a placebo controlled trial.

19 Jan 2016

Rapastinel demonstrates pro-cognitive benefits in animal model of cognitive impairment

Allergan plc, a leading global pharmaceutical company, announced today that new data on the investigational medication rapastinel (GLYX-13) and its lack of impairment on cognitive function were published in the peer-reviewed journal Behavioural Brain Research.

19 Jan 2016

Receptor News and Research

Alternative splicing: a new approach to drug development? An interview with Lucy Donaldson

FDA-approved blood pressure drug reduces cell damage linked to Alzheimer's disease

Sphingosine kinase inhibitor slows castration-resistant prostate cancer cell growth

Certain viral infections during pregnancy could cause behavioral changes in offspring

Vestibular test may aid ocular myasthenia gravis diagnosis

Researchers develop new painkiller as strong as morphine but not addictive

Using centrifugal elutriation and flow cytometry to answer biological questions: an interview with Peter Lopez

Nutrition and breast cancer; starving triple negative breast cancer cells to death: an interview with Associate Professor Jeff Holst

Palonosetron effective anti-emetic for paediatric chemotherapy patients

Neurons protect intestinal tissue from over-inflammation

Sunitinib versus everolimus trial highlights non-clear cell RCC patient response heterogeneity

Swedish research group publishes scientific discoveries concerning EKC in Acta Ophthalmologica journal

Allergan announces publication of VIBERZI Phase III trial results in The New England Journal of Medicine

Northwestern researchers use fruit fly genetics to understand how things may go wrong in cancer

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

New study sheds light on possible role of ion channel in the immune system

Estrogen helps women fight flu virus better than men

Selexipag reduces clinical events in PAH patients

TG4010 vaccine promising in advanced NSCLC

Rapastinel demonstrates pro-cognitive benefits in animal model of cognitive impairment

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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