Respiratory News and Research

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Flavonoid-based inhibitors targeting SARS-CoV 3CL protease for the treatment of SARS-CoV-2 infection

A new study has explored a series of potential flavonoid inhibitors targeting 3CL protease of SARS-CoV.

9 Aug 2021

Young, healthy adult infected by COVID-19 suffers CNS lymphocytic vasculitis

Although COVID-19 is primarily treated as a respiratory disease, patients often experience neurological problems, such as headaches, anxiety, depression and cognitive issues, which can persist long after other symptoms have resolved.

9 Aug 2021

Expert panel recommends standardized criteria to define placental SARS-CoV-2 infection

A panel of experts convened by the National Institutes of Health has recommended standardized criteria to define infection of the placenta with SARS-CoV-2, the virus that causes COVID-19.

9 Aug 2021

Study of antibody responses to COVID-19 mRNA vaccine in convalescent individuals

In addition to clinical trials conducted to determine the safety and efficacy of the mRNA vaccines, additional studies began describing the serological response to the vaccines under "real-world" conditions, especially with the onset of the SARS-CoV-2 variants and case reports of vaccine escape.

9 Aug 2021

Research shows how SARS-CoV-2 variants are evolving towards increased furin cleavage efficiency

The spike protein comprises of two subunits: S1 subunit having the receptor-binding domain (RBD) that helps it to bind to the angiotensin-converting enzyme 2 (ACE2), which is present on the cell surface of the host, and the S2 subunit that helps in the fusion of the cellular membrane and the viral membrane.

9 Aug 2021

New compound inspired by tapeworm drugs shows two-pronged effectiveness against COVID-19

A group of medications long prescribed to treat tapeworm has inspired a compound that shows two-pronged effectiveness against COVID-19 in laboratory studies, according to a new publication appearing online in the journal ACS Infectious Disease.

9 Aug 2021

Scientists identify calpeptin as potential inhibitor of SARS-CoV-2

A team of US-based scientists has recently conducted a robust high-throughput screening to identify potential entry inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The screening identifies calpeptin as a potent and highly specific inhibitor of SARS-CoV-2 and its variants. The study is currently available on the bioRxiv* preprint server.

9 Aug 2021

Cetylpyridinium chloride-containing mouthwashes shown to inhibit SARS-CoV-2 in oral cavity

A team of international scientists has recently demonstrated the usefulness of cetylpyridinium chloride-containing mouthwashes in inhibiting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reducing the risk of viral transmission. The study is currently available on the bioRxiv* preprint server.

9 Aug 2021

Computational study identifies key areas of the SARS-CoV-2 genome prone to mutation

By retrieving 329,942 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) records from the GISAID database, researchers from a software company in Cambridge described genetic variability of SARS-CoV-2 in order to inform further studies. Their findings are currently available on the bioRxiv* preprint server while it undergoes peer review.

9 Aug 2021

New insight into impact of SARS-CoV-2 mutations on receptor binding

A recent study by Canadian researchers, currently available on the bioRxiv* preprint server, contributes to the growing body of literature on emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by appraising the impact of single mutations on their overall antigenicity and binding affinity for the angiotensin-converting enzyme 2 (ACE2) receptor.

9 Aug 2021

Virus-like particles reveal unexpected mechanism for increased fitness and spread of SARS-CoV-2

Researchers in the United States have developed a new model for testing mutations in the four structural proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

9 Aug 2021

New phylogenomic platform identifies increased recombination rates in SARS-CoV-2

Researchers in the United States, Australia and the UK have developed a novel method that enables the evolutionary ancestry (phylogeny) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to be comprehensively searched for recombinant lineages.

8 Aug 2021

High rates of COVID-19 vaccine motivation among Latinx parents – a single center study

A new study demonstrates high motivation among Latinx parents to get their children vaccinated against COVID-19.

8 Aug 2021

Long COVID may be due to persistent immune disturbances

A new study discusses abnormalities in the immune response following COVID-19 in samples collected from patients who have recovered from COVID-19.

8 Aug 2021

New study describes SARS-CoV-2 ExoN enzyme that promotes antiviral resistance

A new study describes the structure of a crucial enzyme present in SARS-CoV-2.

8 Aug 2021

Science academies offer recommendations to improve pandemic preparedness in the future

In the run-up to the summit of the G20 states on October 30 and 31, 2021, in Rome/Italy, the science academies of these countries (Science20 Dialogue), including the German National Academy of Sciences Leopoldina, have published the joint statement "Pandemic preparedness and the role of science".

6 Aug 2021

Respiratory News and Research

Flavonoid-based inhibitors targeting SARS-CoV 3CL protease for the treatment of SARS-CoV-2 infection

Young, healthy adult infected by COVID-19 suffers CNS lymphocytic vasculitis

Expert panel recommends standardized criteria to define placental SARS-CoV-2 infection

Study of antibody responses to COVID-19 mRNA vaccine in convalescent individuals

Research shows how SARS-CoV-2 variants are evolving towards increased furin cleavage efficiency

New compound inspired by tapeworm drugs shows two-pronged effectiveness against COVID-19

Scientists identify calpeptin as potential inhibitor of SARS-CoV-2

Cetylpyridinium chloride-containing mouthwashes shown to inhibit SARS-CoV-2 in oral cavity

Computational study identifies key areas of the SARS-CoV-2 genome prone to mutation

New insight into impact of SARS-CoV-2 mutations on receptor binding

Virus-like particles reveal unexpected mechanism for increased fitness and spread of SARS-CoV-2

New phylogenomic platform identifies increased recombination rates in SARS-CoV-2

High rates of COVID-19 vaccine motivation among Latinx parents – a single center study

Long COVID may be due to persistent immune disturbances

New study describes SARS-CoV-2 ExoN enzyme that promotes antiviral resistance

Science academies offer recommendations to improve pandemic preparedness in the future

FDA approves an intravenous medication to treat patients with Pompe disease

Pfizer/BioNTech COVID-19 vaccine offers decreased protection six months after second dose, suggests Israeli study

SARS-CoV-2 Beta variant associated with more critical and fatal disease than Alpha, suggests Qatar study

Study reports on COVID-19 vaccine-related adverse events in young Japanese population

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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