Ribosome News and Research

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SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Researchers presented a functional analysis of the SARS-CoV-2 open reading frame 3c (ORF3c) protein.

17 Nov 2022

Newly identified pathway transforms biologically inert peptide into structurally complex antibiotics

Researchers in the Princeton University Department of Chemistry have discovered a new multi-step pathway through which bacteria found in the mammalian gut produce antimicrobial peptides.

14 Nov 2022

Scientists determine 5,072 essential human genes

In a recent study published in the journal Cell, researchers examined the phenotypic landscape of multiple elusive essential human genes to create a detailed genotype-phenotype resource outlining the phenotypic consequences of disrupting fundamental cellular processes.

8 Nov 2022

New method helps gain fundamental insights into ribosome function

Inside tiny cellular machines called ribosomes, chains of genetic material called messenger RNAs (mRNAs) are matched with the corresponding transfer RNAs (tRNAs) to create sequences of amino acids that exit the ribosome as proteins.

1 Nov 2022

The effect of ORF3c, a SARS-CoV-2 accessory protein, on cellular innate immune responses, autophagy, and lung cell mitochondrial metabolism

Researchers explored the role of the ORF3c, a SARS-CoV-2 accessory protein not so extensively studied as yet.

7 Oct 2022

SARS-CoV-2-encoded protein ameliorates neuromuscular degeneration in fly models of neurodegenerative diseases

Researchers explored the in vivo efficacy of SARS-CoV-2-encoded proteins against neuromuscular degeneration associated with ribosome stalling.

3 Oct 2022

Scientists visualize antibiotics in action inside a pathogenic bacterium

Every living cell relies on proteins in order to function and the process of protein synthesis – translation – is critical for survival.

28 Sep 2022

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

A recent PLoS ONE study detected neutralizing nanobodies against SARS-CoV-2 from nanobody phage display libraries and via in vitro and ex vivo high-throughput screenings.

2 Sep 2022

Eating grapes may reduce the risk of fatty liver disease

In a recent study published in the journal Foods, eating grapes can extend life expectancy by five years and reduce non-alcoholic fatty liver disease risk in mice fed high-fat diets.

17 Aug 2022

New method could lead to more efficient production of next-generation antibiotics

An international team of researchers has developed a method for altering one class of antibiotics, using microscopic organisms that produce these compounds naturally.

27 Jul 2022

The global succinylation and protein abundance in SARS-CoV-2–infected cells

Researchers assessed the global succinylation of SARS-CoV-2-infected host cells.

14 Jul 2022

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

A new study explores the role of non-structural protein 1 (NSP1) in SARS-CoV-2 infection and pathogenesis.

16 Jun 2022

Advanced microscopy techniques offer detailed insight into inner workings of cells' powerhouses

Using advanced microscopy techniques, researchers at Karolinska Institutet and Stockholm University in Sweden have visualized in unprecedented detail the machinery that the cells' powerhouses, the mitochondria, use to form their proteins.

8 Jun 2022

Cryogenic electron microscopy used to determine the structure of fungal ribosome

Most people carry the fungus Candida albicans on their bodies, without this causing many problems. However, a systemic infection with this fungus is dangerous and difficult to treat.

25 May 2022

The promise of RNA medicine is targeted and personalized

The development of messenger RNA (mRNA) vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has only increased the impetus in this field.

11 May 2022

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

As part of World Malaria Day 2022, we interview Karine Le Roch PH.D., about her latest research into how novel antimalarial therapeutic strategies could be on the horizon, after identifying two proteins that are critical to the survival of the malaria parasite, Plasmodium falciparum.

25 Apr 2022

Ribosome News and Research

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Newly identified pathway transforms biologically inert peptide into structurally complex antibiotics

Scientists determine 5,072 essential human genes

New method helps gain fundamental insights into ribosome function

The effect of ORF3c, a SARS-CoV-2 accessory protein, on cellular innate immune responses, autophagy, and lung cell mitochondrial metabolism

SARS-CoV-2-encoded protein ameliorates neuromuscular degeneration in fly models of neurodegenerative diseases

Scientists visualize antibiotics in action inside a pathogenic bacterium

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

Eating grapes may reduce the risk of fatty liver disease

New method could lead to more efficient production of next-generation antibiotics

The global succinylation and protein abundance in SARS-CoV-2–infected cells

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

Advanced microscopy techniques offer detailed insight into inner workings of cells' powerhouses

Cryogenic electron microscopy used to determine the structure of fungal ribosome

The promise of RNA medicine is targeted and personalized

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

The diversity of transcriptional targets between four different coronavirus nsp1 proteins

Researchers discover a four-protein complex that may play key role in generating ribosomes

How does the non-structural protein 1 affect COVID-19 pathogenicity?

UH researchers receive grant for developing new imaging technique to peer into ribosomes

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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