Short Chain Fatty Acids News and Research

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Butyrate and propionate are two important short-chain fatty acids (SCFAs) produced in the human gut. They have been shown to have significant immune system effects in the intestinal mucosa, by inducing the differentiation of T-regulatory cells via inhibition of histone deacetylase (HDAC). This enzyme keeps chromatin from unwinding and, therefore, inhibits gene transcription.

From gut to brain: How diet can influence Alzheimer's and Parkinson's outcomes

Diet modification and alterations in the intestinal microbial population could impact the disease course of Alzheimer’s and Parkinson’s diseases.

23 Jan 2024

Exploring the impact of probiotics on preventing weight gain from psychiatric medication

Researchers discuss the effectiveness of probiotics and their use in reducing drug-induced weight loss.

19 Jan 2024

How do SCFAs modulate cardiometabolic risk in normal-weight adults?

How SCFAs modulate cardiometabolic disease risk by interacting with an individual's adiposity parameters and diet.

18 Jan 2024

Dietary factors influencing GLP-1 secretion: a new perspective in diabetes and obesity treatment

Researchers in The American Journal of Clinical Nutrition review the impact of diet on GLP-1 secretion in metabolic conditions like obesity and type 2 diabetes, highlighting its potential in treatment and prevention.

16 Jan 2024

Nicotine's surprising effect on gut microbiota and metabolism uncovered

The impact of nicotine exposure on host nutritional status, gut microbial metabolites, and metabolic homeostasis.

15 Jan 2024

Gut microbiota: the new frontier in Alzheimer’s disease research and therapy

The current evidence of the role of gut microbiota in Alzheimer’s disease (AD) pathogenesis.

8 Jan 2024

Neutrophils: Unraveling their multifaceted roles in inflammatory bowel disease and gut microbiota interactions

Research delves into the complex roles of neutrophils in inflammatory bowel disease (IBD), exploring their diverse functions and interactions with the gut microbiota and emphasizing the need for targeted therapies based on these insights.

27 Dec 2023

Gut microbiome diversity predicts cognitive function and brain structure in healthy children

Emerging evidence implicates the gut microbiome in cognitive outcomes and neurodevelopmental disorders, but the influence of gut microbial metabolism on typical neurodevelopment has not been explored in detail.

26 Dec 2023

Maternal microbiome's pivotal role in shaping fetal and neonatal immune systems during pregnancy

Review in Nature Reviews Gastroenterology and Hepatology explores how the maternal microbiome during pregnancy influences the immune systems of the mother, fetus, and neonate, highlighting its impact on long-term health outcomes and the development of pregnancy complications.

18 Dec 2023

Leaky gut linked to depressive disorders: New insights into microbiota-induced epigenetic changes

A study in the journal Genes highlights how a leaky gut can lead to depressive disorders through changes in gut microbiota-derived metabolites, emphasizing the role of diet, environmental factors, and probiotics in managing these conditions.

18 Dec 2023

Poop-based test predicts postoperative infections in liver transplant patients

In a new study, researchers at the University of Chicago were able to predict postoperative infections in liver transplant patients by analyzing molecules in their poop.

15 Dec 2023

Study explores the intricate gut-brain-liver connection and its impact on health

Study reviews the gut-brain-liver axis, revealing the complex interplay between these organs in health and disease and the implications for therapeutic interventions, focusing on how gut microbiota affects liver and brain health.

10 Dec 2023

Flaxseed lignans found to influence gut microbiome and breast cancer risk

A new study demonstrates that the human gut microbiome may be a factor in breast health. Lifestyle and diet have long been known to affect human health.

7 Dec 2023

Link between gut dysbiosis and chronic diseases explored in new study

Study explores the ecological causes of gut dysbiosis and its link to human diseases, revealing how imbalances in gut microbiota composition, influenced by host-derived factors like oxygen and nitrate, contribute to various chronic conditions.

5 Dec 2023

Microbiome-derived molecules combat anxiety and depression caused by methamphetamine

This new article publication from Acta Pharmaceutica Sinica B, discusses how gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner.

30 Nov 2023

Two kiwi fruit every day safe and can replace vitamin C supplementation

Study investigates the health effects of consuming two kiwifruits daily for six weeks. It finds no significant changes in metabolic and inflammatory biomarkers, indicating that regular kiwifruit consumption is safe and increases dietary vitamin C intake without adversely affecting metabolic health.

27 Nov 2023

The future of functional foods: Leveraging Dendrobium officinale for optimal gut health and disease prevention

The structure, extraction, health benefits, and mechanisms of Dendrobium officinale polysaccharides (DOPs).

27 Nov 2023

Fermented foods may have fueled human brain growth, new evolutionary theory proposes

Review in Communications Biology suggests that the external fermentation of foods may have played a key role in the expansion of the hominid brain. The "external fermentation hypothesis" posits that early hominins' practice of fermenting foods externally contributed to brain growth and gut reduction, offering a novel perspective on human evolution and dietary practices.

26 Nov 2023

Is the microbiome linked to post-traumatic stress disorder outcomes?

The potential role of the microbiome-gut-brain axis in this interaction.

21 Nov 2023

Intestinal MCT1 plays a crucial role in sex-dependent metabolic regulation

Monocarboxylate transporter 1 (MCT1) plays a crucial role in the transport of lactate, pyruvate, ketone bodies, and short-chain fatty acids (SCFA), as well as MCT1-targeted drugs in various tissues.

14 Nov 2023