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Taking Advantage of Measuring Molecular Collisional Cross-Sections in Pharma

News-Medical talks to Mike Greig, Director of Pharma at Bruker, about why measuring collisional cross-sections is beneficial to developing new drugs.

From Bruker Life Sciences Mass Spectrometry 10 Feb 2021

New technology helps study muscle biology more clearly

Exercising regularly is one of the best defenses against metabolic diseases, such as obesity and diabetes - but why? It's a question that scientists are still struggling to answer. While exercising changes the molecular behavior of muscles, it's not well understood how these molecular changes improve metabolic health.

13 Jan 2021

Bruker and Evosep announce major progress in unbiased, quantitative true single-cell proteomics

Bruker Corporation and Evosep today announced major progress in high-sensitivity, quantitative true single-cell proteomics, using a modified timsTOF Pro mass spectrometer connected to an Evosep One low-flow chromatography system.

From Bruker Life Sciences Mass Spectrometry 8 Jan 2021

Exhaled breath can aid in the diagnosis of cancer

The air we exhale contains information that can assist with the diagnosis of disease. Researchers at the Fraunhofer Project Hub for Microelectronic and Optical Systems for Biomedicine MEOS are now developing solutions designed to enable the analysis of breath gas for this purpose. Although their research focuses on the early detection of cancer, the same principle could also be applied to distinguish between COVID-19 and other respiratory diseases.

4 Dec 2020

Scientists report the first map of molecular responses of human lung cells to SARS-CoV-2 infection

In a multi-group collaborative involving the National Emerging Infectious Disease Laboratories (NEIDL), the Center for Regenerative Medicine (CReM), and the Center for Network Systems Biology (CNSB), scientists have reported the first map of the molecular responses of human lung cells to infection by SARS-CoV-2.

2 Dec 2020

Tackling the Global Issue of New Psychoactive Substances

News-Medical speaks to Dr. Venita Decker, Dr. Joerg Koehler, and Dr. Andrea Kiehne about the latest challenges in narcotic analysis, and the methods being implemented to help tackle this global NPS issue.

From Bruker BioSpin - NMR, EPR and Imaging 2 Dec 2020

Affinity-Bead Assisted Mass Spectrometry for Proteomics

In this interview, Ghaith Hamza from AstraZeneca talks to News-Medical Life Sciences about the basic principles of Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS) and how Affi-BAMS can help target specific proteins for proteomic applications.

From Bruker Life Sciences Mass Spectrometry 16 Nov 2020

Study reveals 3D structure of key phage component in atomic resolution

Given that phages are able to destroy bacteria, they are of particular interest to science. Basic researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin are especially interested in the tube used by phages to implant their DNA into bacteria.

16 Nov 2020

MIT researchers unravel the molecular structure of key coronavirus protein

MIT chemists have determined the molecular structure of a protein found in the SARS-CoV-2 virus. This protein, called the envelope protein E, forms a cation-selective channel and plays a key role in the virus's ability to replicate itself and stimulate the host cell's inflammation response.

12 Nov 2020

Thermo Fisher Scientific and Symphogen extend collaboration to boost drug discovery and development

Thermo Fisher Scientific, the world leader in serving science, and Symphogen, an affiliate of and the antibody center of excellence within the international pharmaceutical company, Servier, announce the extension of a strategic collaboration to deliver industry-proven, innovative characterization and quality control workflows for the simplified analysis of complex therapeutic proteins to advance biopharmaceutical discovery and development.

From Thermo Fisher Scientific Inc. 2 Nov 2020

High Throughput Identification and Quantification of Breast Cancer With NMR-Based Metabolomics

Breast cancer is the leading cause of cancer-related death among the female population globally, despite the ever-growing technology of early detection.

From Bruker BioSpin - NMR, EPR and Imaging 30 Oct 2020

A breakthrough for rapid screening: Be among the first to experiment with Restek coated blade spray technology!

Restek coated blade spray (CBS) technology accelerates rapid-screening analyses to a new level of efficiency and speed. Based on strong sample extraction and ionization foundations, CBS technology bridges the gap between sample preparation and MS/MS analysis by providing a product that can go directly from the sample to the mass spectrometer.

From Restek Corporation 21 Oct 2020

New machine learning concepts can help develop novel drugs

Tandem mass spectrometry is a powerful analytical tool used to characterize complex mixtures in drug discovery and other fields.

14 Oct 2020

New approach uses noise to characterize and cross-calibrate spectroscopy instruments

Optical spectrometers are instruments with a wide variety of uses. By measuring the intensity of light across different wavelengths, they can be used to image tissues or measure the chemical composition of everything from a distant galaxy to a leaf.

14 Oct 2020

New aerosol field data can help improve global climate models

Smoke from the many wildfires burning in the West have made air quality hazardous for millions of people in the United States. And it is the very tiniest of the aerosol particles in that air that make it particularly harmful to human health. But for decades, we haven't known how long these particles actually stay aloft.

7 Oct 2020

Promising breath analysis for early-stage cancer testing takes a leap forward

The global quest to use a person's breath analysis for rapid, inexpensive and accurate early-stage testing for cancer and other diseases has taken a leap forward.

5 Oct 2020

Researchers receive NCI grant to study role of collagens in breast cancer

An MUSC Hollings Cancer Center researcher received a $3 million grant from the National Cancer Institute to study how patterns of collagens can serve as biomarkers of breast cancer risk and potentially reveal clues to what might be driving health disparities.

1 Oct 2020

BioChromato's RAPID Slit Seals offer significant benefits over conventional silicone mats

BioChromato Inc. reports that the pharmacokinetics department at a leading Japanese pharmaceutical company has found that RAPID Slit Seals offer significant benefits compared to conventional silicone mats for maintaining the integrity of microplate samples.

From BioChromato Inc. 17 Sep 2020

Newly identified mechanism regulates the distensibility of the heart

A healthy heart beats 50 to 100 times a minute and pumps 8,000 litres of blood around our body every day. A precondition for this function is the elasticity of the cardiac walls, which dilate as blood flows in (diastole) and contract again as the blood flows out (systole).

15 Sep 2020

Exploring the Relationship Between Mass Spectrometry and Informatics

Mass spectrometry has always had a powerful synergy with computers. Computers have pushed mass spectrometry forward at key junctures in it’s history from data collection to instrument operation to data analysis.

From Bruker Life Sciences Mass Spectrometry 9 Sep 2020