Synovial Fluid News and Research

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Methotrexate reduces joint damage in hand osteoarthritis

A new study presented at the 2019 ACR/ARP meeting shows that methotrexate stopped further damage to the hand joints and even perhaps improved bone remodeling in patients with osteoarthritis (OA) of the hand, when they were assessed at 3 and 12 months.

11 Nov 2019

Antibody that targets CXCR6 prevents and reverses multiple sclerosis in mouse model

Multiple sclerosis, an autoimmune disorder, is known to be driven by "helper" T cells, white blood cells that mount an inflammatory attack on the brain and spinal cord. A new study from Boston Children's Hospital pinpoints the specific subgroup of helper T cells that cause MS, as well as a protein on their surface, called CXCR6, that marks them.

4 Oct 2019

Joint lubricating fluid triggers pain response from nerve cells in osteoarthritic patients

A team at the University of Cambridge has shown how, in osteoarthritis patients, the viscous lubricant that ordinarily allows our joints to move smoothly triggers a pain response from nerve cells similar that caused by chilli peppers.

14 Aug 2019

New, quantitative method for assessment of molecular biomarker for osteoarthritis

For the first time, scientists at Wake Forest Baptist Medical Center have been able to measure a specific molecule indicative of osteoarthritis and a number of other inflammatory diseases using a newly developed technology.

13 Mar 2019

Galectins play a key role in the degeneration of cartilage in osteoarthritis

A network of carbohydrate binding proteins - so-called galectins - plays an important role in the degeneration of cartilage in osteoarthritis.

19 Dec 2018

OrthoSera presents first-in-man study results of hyperacute serum in knee osteoarthritis

OrthoSera GmbH, an orthobiologics company developing serum-based solutions for musculoskeletal indications announces results of its first-in-man pilot clinical study of hyperacute serum on 36 patients in knee osteoarthritis.

27 Sep 2018

Scientists discover gene that predicts arthritis severity

Scientists have discovered a new gene that is associated with disease severity in rheumatoid arthritis. HIP1 produces an inflammatory molecule which drives RA.

26 Jul 2018

Combination of antibodies shown to cause rheumatoid arthritis

Researchers have shown that severe inflammation and joint damage in rheumatoid arthritis (RA) is primarily caused by a combination of different antibodies.

12 Jun 2018

Immune response in RA patients linked to inflammation and joint damage

To diagnose rheumatoid arthritis, antibodies to the amino acid citrulline are commonly measured. A new study from Uppsala University shows that a broad mix of different antibodies in the joints is the dominant factor that can be associated with severe inflammation and joint damage.

12 Jun 2018

Researchers develop new method that could increase longevity of artificial hips

Mechanical engineering researchers have developed a method that could extend the life of an artificial hip by adding an array of microscopic indentations that increase the thickness of a lubricating film on its surface.

14 May 2018

BWH bioengineers develop flare-responsive hydrogel to treat arthritis

Arthritis flares - the unpredictable and often sudden worsening of arthritis symptoms -- can be debilitating. These episodes can make the management of inflammatory arthritis, which includes rheumatoid arthritis and psoriatic arthritis, challenging for patients and physicians.

3 Apr 2018

Maintaining adequate vitamin D may help prevent onset of inflammatory diseases

Maintaining sufficient vitamin D levels may help to prevent the onset of inflammatory diseases like rheumatoid arthritis, research led by the University of Birmingham has discovered.

21 Nov 2017

IBS scientists invent hydrogel to combat rheumatoid arthritis

IBS scientists at the Center for Self-Assembly and Complexity, within the Institute for Basic Science, invented a hydrogel to fight rheumatoid arthritis and other diseases. Published in Advanced Materials, this jelly-like material could be used to absorb extra fluids in swelling joints and release drugs.

11 Oct 2017

Researchers uncover mechanism that contributes to joint inflammation in rheumatoid arthritis patients

New research findings published in the Journal of Leukocyte Biology, suggest that synovial CD4+ T cells that produce IL-21 contribute to joint inflammation by activating synovial fibroblasts in rheumatoid arthritis patients.

2 Mar 2017

Running can reduce joint inflammation, study finds

We all know that running causes a bit of inflammation and soreness, and that's just the price you pay for cardiovascular health. You know; no pain, no gain.

9 Dec 2016

Researchers develop new blood test for diagnosis of early-stage osteoarthritis

Patients could soon be diagnosed with early-stage arthritis several years before the onset of physical and irreversible symptoms, thanks to a new test developed by researchers at the University of Warwick.

27 Oct 2016

Immunotherapy-treated cancer patients may develop rheumatic disorders

Oncologists need to be aware of the potential for rheumatological diseases in patients with cancer following treatment with immune checkpoint inhibitors, say US investigators.

30 Jun 2016

Natural proteins could be used to test new replacement hip, knee joints

A new study suggests that natural proteins can be used to effectively test new replacement hip and knee joints in the laboratory. The work could help with improving design in order to reduce wear and tear and increase the lifespan of such prosthetics.

20 May 2016

Phase 3 study: Sarilumab monotherapy meets primary endpoint in active rheumatoid arthritis patients

Regeneron Pharmaceuticals, Inc. and Sanofi today announced that a Phase 3 monotherapy study met its primary endpoint demonstrating that sarilumab was superior to adalimumab (marketed by AbbVie as HUMIRA) in improving signs and symptoms in patients with active rheumatoid arthritis (RA) at Week 24.

11 Mar 2016

TTR protein causes autoimmune reaction in joints of juvenile idiopathic arthritis patients

Juvenile idiopathic arthritis, or JIA, is the most common form of childhood arthritis. It appears to be an autoimmune disease, caused by antibodies attacking certain proteins in a person's own tissue. But no "autoantigens" -- the proteins triggering an immune attack -- have been linked to JIA.

27 Feb 2016