The ACQUITY UPLC I-Class PLUS System offers industry-leading separations performance, opening up new possibilities for maximizing the resolution and sensitivity of your methods, improving the characterization of the samples, and increasing productivity to advance laboratory science. Users are searching for answers to the most difficult scientific challenges, and the scientific tools they use and the information they offer can make all the difference.
The lab can do extremely effective, quick separations from the best ultra-low dispersion and delay volume in the industry with the ACQUITY UPLC I-Class PLUS System. The lab can obtain narrow, ultra-efficient peaks, improving the sensitivity of any mass spectrometer and making it easier to characterize even the most complicated samples.
Specifications
Source: Waters Corporation
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| Maximum operating pressure |
18,000 psi |
| pH Range* |
1–12.5 |
| Operating flow rate range |
Up to 2.0 mL/min |
| Sample flow path |
Stainless-steel |
| Sample carryover |
<0.001% (Caffeine) under UV conditions |
| Sample compartment |
4–40 °C |
| Pump options |
Binary |
| Solvent conditioning |
Active Pre-heating |
| Column tracking |
eCord Technology tracks column information and archives column usage |
| Column capacity |
Up to 2 columns of 150 mm length and up to 4.6 mm I.D. |
| Maximum sample capacity |
Up to 20 plates (with Sample Organizer) |
| Detector options |
PDA Detector
TUV Detector
FLR Detector
RI Detector
ELS Detector
Mass Spectrometers |
| External control |
Empower Software
MassLynx Software
waters_connect
UNIFI Scientific Information System |
Physical specifications
QSM or BSM, SM-FTN, CHA |
Width: 34.3 cm (13.5 in.)
Height: 71.1 cm (28 in.)
Depth: 71.2 cm (28 in.) |
* For specific test conditions, contact Waters sales representative
Overview
- The Binary Solvent Manager, which has an integrated solvent-select valve and is perfect for up to four solvents, allows users to combine binary solvents precisely and accurately.
- Utilize the flow-through needle and fixed loop injector choices to achieve sample injection adaptability based on the application.
- Utilize programmable method parameters to control ultra-low carryover and guarantee compatibility with even the most sensitive mass spectrometers.
- Obtain precise temperature control across the column; this feature can be set up for one or two columns with active preheating.
- Enhance any mass spectrometer’s performance by maximizing chromatographic resolution to reduce co-elution interference.
- Use the Waters Empower-based automated system qualification tool (SQT) to reduce the time and cost involved in yearly qualification.
- Empower, Masslynx, UNIFI, and a number of third-party software packages are supported.
Recommended Use: Improve sample characterization while increasing productivity to further laboratory science.
Get a clearer picture of your sample
In this example, the impurity analysis of tetracaine was run under the same conditions on the ACQUITY UPLC I-Class PLUS System (system band spread of 4 µL) and a UHPLC system (system band spread of 20 µL). Significantly better resolution was achieved on the ACQUITY UPLC I-Class PLUS System. Image Credit: Waters Corporation
The ACQUITY UPLC I-Class PLUS System offers separations that can enhance the research while improving resolution through decreased system dispersion.
Reduce solvent use, expedite access to the data required for important choices, and shorten analysis timeframes. The ACQUITY UPLC I-Class PLUS System offers a clear picture of what is inside the sample and is made to fit into the current LC workflow.
An inlet that improves the performance of any MS
A high sensitivity UPLC-MS/MS bioanalytical methodology for the quantification of midazolam and imipramine in rat plasma using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer in combination with an ACQUITY UPLC I-Class PLUS System. Image Credit: Waters Corporation
The ACQUITY UPLC I-Class PLUS System was created especially for the fast-paced, cutting-edge research labs where LC-MS is essential.
The lab will use the ACQUITY UPLC I-Class PLUS System to:
- Narrow peak widths increase ionization efficiency and resolution while improving mass spectrometry sensitivity
- Enhance sensitivity with industry-leading carryover performance
- Improve sample characterization by selective isolation with multidimensional UPLC configurations
- Achieve extremely rapid analysis times with an ultra-low delay volume
Achieve ultimate peak capacity with CORTECS Columns
By pairing the ultra-low dispersion ACQUITY UPLC I-Class PLUS System with high-efficiency CORTECS Columns, you’ll achieve new levels of UPLC performance. These 1.6 µm columns deliver exceptional levels of efficiency, performance, and throughput, resulting in narrower peaks and higher peak capacity. Image Credit: Waters Corporation
The ACQUITY UPLC I-Class PLUS System, along with CORTECS 1.6 µm solid-core columns, allows scientists to reach higher levels of resolution, sensitivity, and chromatographic performance. CORTECS Columns with the ACQUITY UPLC I-Class PLUS System allow users to boost resolution for even the most difficult samples while providing the flexibility and power required to rapidly separate a wide range of compounds.