The Xevo G3 QTof allows users total confidence in the results by maximizing sample information for the analytes from thorough characterization to precise quantification.
The Xevo G3 QToF broadens the simplicity and scope of characterization, from difficult small compounds to sophisticated biotherapeutics.
Updates to the ion optics design ensure consistent durability and performance, with the introduction of core technologies for extensive quantitation capabilities. The Xevo G3 QTof, built on an expanding set of informatics tools, has the lab covered.

Introducing the new generation of Xevo. Image Credit: Waters Corporation

Get a step change in chromatographic performance when the Xevo G3 QTof pairs with the ACQUITY Premier System. Image Credit: Waters Corporation
Overview
- Ultimate performance: Ensure optimum analyte coverage, including better transmission of low mass labile species, while maintaining excellence in classic biopharmaceutical operations and meeting future needs to characterize new modalities
- Extended flexibility: Improve quantitative capabilities by expanding the inter- and intra-spectrum dynamic range to allow for thorough quantitative/qualitative analysis, making it perfect for screening and targeted applications
- Unquestioned confidence: With improved ion optics, users can achieve constant data quality and reproducibility, allowing users to sustain performance and productivity over time
Recommended Use: Characterize and quantify a wide range of molecules using a single, analytical workhorse.
Ultimate performance for a range of analytes

Xevo G3 QTof provides a significant increase in sensitivity for challenging labile compounds. Image Credit: Waters Corporation
Increase the demands placed on the analytical systems to increase the lab's capabilities. In addition to improving the analysis of difficult small molecules (with improvements to the ion optics and detection system to maximize transmission and dynamic range), the Xevo G3 QTof integrates new technology building blocks that better characterize complex biologics (with a m/z 16,000 calibration range and customized informatics).
By effectively transmitting low mass, labile species, the Xevo G3 QTof with the StepWave XS allows users to improve analytical fidelity and compound coverage.
Connected productivity for harmonized workflows
The waters_connect ecosystem provides smooth, compliant processes for tracking and comprehending biotherapeutic variation. waters_connect connects individuals and systems with full data traceability, security-controlled access, and networked deployment's scalability and operational efficiency.
Delivering qualitative and quantitative performance

Demonstrating 5 orders of linear dynamic range in Tof-MRM mode. Image Credit: Waters Corporation
Utilize the system to its fullest potential with a versatile, multipurpose tool that produces excellent quantitative and qualitative data sets. With improvements to its basic technology, the Xevo G3 QTof has been developed to particularly meet these demands, offering up to five orders of linear dynamic range for focused analysis.
With an up to 4× improvement in spectrum dynamic range, the Xevo G3 QTof can identify and measure components of interest in the most complicated matrices for untargeted and screening investigations.
Unquestioned confidence with consistent robustness and reproducibility

Minimize contamination and increase uptime with optimized ion optics. Image Credit: Waters Corporation
Instrument stability and uptime are essential in high-throughput, fast-paced settings. The Xevo G3 QTof’s improved design maintains long-term performance and productivity, ensuring consistent robustness and reproducibility.
The Xevo G3 QTof is a genuine analytical workhorse that consistently and dependably produces high-quality data, thanks to its upgraded ion optics design and improved ion beam conditioning.