With the Xevo TQ Absolute, an instrument that offers absolute performance, users can have complete confidence in reaching lower limits of quantitation for challenging negative ionizing substances.
The Waters Xevo TQ Absolute Mass Spectrometer is a very small, environmentally friendly tandem quadrupole mass spectrometer that helps the lab reach and sustain high performance and productivity. With the Xevo TQ Absolute, users can quantify those difficult, tiny mass, negative ionizing substances with complete sensitivity and confidence thanks to Xevo’s reliable performance. All while knowing that the ESG commitments are being taken into account.
Specifications
System Hardware Specifications. Source: Waters Corporation
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| API sources and ionization modes |
High-performance ZSpray dual-orthogonal API sources:
1) Multi-mode source – tool-free ESI/APCI/ESCi* (standard) NB – Dedicated APCI requires an additional probe (optional)
2) UniSpray ion source (optional)
3) Tool-free APCI probe (optional)
4) nanoFlow™ ESI source* (optional)
5) ASAP* (optional)
6) APGC ion source* (optional)
Optimized gas flow dynamics for efficient ESI desolvation
Tool-free source exchange
Vacuum isolation valve
Tool-free access to user-serviceable elements
Plug-and-play probes
De-clustering cone gas
Software control of gas flows and heating elements |
| UniSpray ion source option |
UniSpray is an ionization technique designed to broaden the scope of compounds which can be analyzed in a single run, including those which typically optimize in ESI, APCI or APPI. Enhanced ionization efficiency and desolvation allow the potential to combine several methodologies into one, or simply enable the operator to keep the same source for multiple methods, requiring less time performing set-up and routine maintenance, and more time delivering results |
| Ion source transfer optics |
StepWave XS ion transfer optics delivering class-leading UPLC™-MS/MS sensitivity.
The unique off-axis design and segmented quadrupole second stage dramatically increase the efficiency of ion transfer from the ion source to the quadrupole MS analyzer at the same time as actively eliminating undesirable neutral contaminants |
| Mass analyzer |
Two high-resolution, high-stability quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers |
| Collision cell |
T-Wave enabled for optimal MS/MS performance at high data acquisition rates;
Software programmable gas control |
| Detector |
Low-noise, off-axis, long-life photomultiplier XDR Detector |
| Vacuum system |
One splitflow turbomolecular pump
One vacuum backing pump |
| Dimensions |
Width: 43.0 cm (16.9 in.)
Height: 79.0 (31.1 in)
Depth: 96.0 (37.8 in) |
| Regulatory approvals/marks |
CE, CB, NRTL (CAN/US), RCM |
* Not available with waters_connect.
System Software Specifications. Source: Waters Corporation
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| Software |
Systems supported on waters_connect and MassLynx version 4.2 or later |
| System setup and method development |
System parameter checks and alerts
Integrated sample/calibrant delivery system + programmable divert valve Automated mass calibration
Automated sample tuning
Automated MRM method development
UPLC-MS/MS System Check – on-column performance test |
| Automated MRM scheduling (acquisition rate assignment) |
Dwell time, inter-channel delay time and inter-scan delay time for individual channels in a Multiple MRM experiment can be automatically assigned (using the Auto-Dwell feature) to ensure that the optimal number of MRM data points per chromatographic peak are acquired. The Auto-Dwell feature dynamically optimizes MRM cycle times to accommodate retention time windows that overlap. This greatly simplifies MRM method creation, irrespective of the number of compounds in a single assay, while at the same time ensuring the very best quantitative performance for every experiment |
| waters_connect Software |
The waters_connect Software provides a modern user experience with a HUB design and apps that provide a consistent connected user experience across all applications. It is built for applications with convenient access to scientific apps allowing accelerated time-to-results and result quality. There are common utilities that complete the end-to-end workflow and help increase productivity and efficiency. Confidently report results with accurate, reliable, regulation-standard data from application-focused quantitative workflows with built in traceability for utmost integrity. |
Performance Capabilities. Source: Waters Corporation
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| Acquisition modes |
Full scan MS
Product ion scan
Precursor ion scan
Constant neutral loss scan
Multiple reaction monitoring (MRM)
Simultaneous Full scan and MRM (RADAR) |
| RADAR |
An information-rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components |
| Mass range |
2 to 2048 m/z |
Compare Xevo TQ systems
Source: Waters Corporation
| |
Xevo TQ-S micro |
Xevo TQ Absolute |
| Dimensions (w x h x d) |
35.6 x 60 x 93 cm |
43 x 79 x 96 cm |
| Sensitivity key |
★★★ |
★★★★★ |
| Mass range |
2 to 2048 m/z |
2 to 2048 m/z |
| Chromatographic configuration compatibility |
ACQUITY Premier
ACQUITY UPC2*
ACQUITY UPLC
ACQUITY UPLC M-Class*
APGC* |
ACQUITY Premier
ACQUITY UPLC
ACQUITY UPLC M-Class*
APGC* |
| Ion sources compatibility |
APCI
APGC*
ASAP*
ESCi*
ESI
ionKey*
Nanoflow*
UniSpray |
APCI
APGC*
ASAP*
DESI XS*
ESCi*
ESI
Nanoflow*
UniSpray |
| Acquisition modes |
Full scan
Product scan
Precursor ion scan
Constant neutral loss scan
Multiple reaction monitoring (MRM)
Simultaneous Full Scan and MRM (RADAR) |
Full scan
Product scan
Precursor ion scan
Constant neutral loss scan
Multiple reaction monitoring (MRM)
Simultaneous Full Scan and MRM (RADAR) |
| Detector ** |
Low noise, off-axis, long-life photomultiplier** |
Low noise, off-axis, long-life photomultiplier** |
| Ion source transfer optics |
StepWave |
StepWave XS |
| MRM speed |
555 MRM/ sec |
500 MRM/ sec |
| Regulatory approval *** |
✓ |
✓ |
| Third party software interfaces |
LIMS interface
MassLynx SkyLine interface |
LIMS interface
MassLynx SkyLine interface |
| MassLynx security |
Yes |
Yes |
| Software options |
- MassLynx v4.2
- waters_connect for Quantitation
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- MassLynx v4.2
- waters_connect for Quantitation
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* Not available with waters_connect
** Less than 1% of Waters’ tandem quadrupole mass spectrometers require a detector replacement on an annual basis. [Source: Waters’ internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022]
*** Regulated approval marks include CE, CB, NRTL (Canada/USA), RCM
Overview
- Absolute performance: Lower quantitation limits are achieved to fulfill regulatory requirements, with up to 15× higher sensitivity for challenging negative ionizing compounds than the previous product
- Absolute efficiency: Improve environmental sustainability and reduce laboratory operational expenses with an instrument that consumes about 50% less energy and gas and generates 50% less heat than most other high-performance TQ mass spectrometry devices on the market
- Absolute confidence: Ensure consistent robustness and repeatability to maintain performance and productivity throughout time
- Absolute productivity: Increase productivity with adaptable software solutions, such as waters_connect, a modern, intuitive informatics platform that can reduce up to 50% of data review time while ensuring data quality
Recommended Use: Reach lower quantitation limits and meet regulatory standards, even for difficult negative ionizing compounds.
Achieve absolute performance with improved sensitivity
Xevo TQ Absolute provides significantly increased sensitivity, particularly for negative ion compounds such as polar pesticides. Image Credit: Waters Corporation
Users demand an instrument that provides absolute performance to achieve lower quantitation limits and meet regulatory standards, even for difficult negative ionizing compounds. Xevo TQ Absolute has up to 15× greater sensitivity for tough negative ionizing compounds than the previous product, allowing users to make solid decisions quickly.
Improve sustainability and lower operational costs
Many businesses are attempting to actively address environmental sustainability while also lowering operational costs. The Xevo TQ Absolute allows you to do just that. The Xevo TQ Absolute was designed to reduce electricity use, gas consumption, and BTU/hr output, reducing the demand for air conditioning and cutting expenditures.
The Xevo TQ Absolute also improves analytical capabilities per square foot of lab space by reducing the LC-MS/MS footprint, allowing laboratory managers to fully optimize their facilities and maximize efficiency.
Waters Xevo TQ Absolute**. Source: Waters Corporation
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| Relative Bench Width |
100% |
| Power Consumption |
1460 W |
| Air Conditioning Demand (Heat Displacement) |
4980 Btu/h |
| Nitrogen/Zero-Grade Air Consumption |
23 L/min |
| Audible Noise |
59.2 dB |
**Source: Xevo TQ Absolute Site Preparation Guide, power consumption range mid-point of 960 W + Ebara rough pump 500 W
SCIEX™ 7500*. Source: Waters Corporation
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| Relative Bench Width |
184% |
| Power Consumption |
3077 W |
| Air Conditioning Demand (Heat Displacement) |
10,500 Btu/h |
| Nitrogen/Zero-Grade Air Consumption |
52 L/min |
| Audible Noise |
68 dB |
*Source: Accessed January 2022 related to document RUO-IDV-01-9809-G SCIEX Triple Quad 7500 LC-MS/MS System - QTRAP Ready Site Planning Guide
Ensure absolute productivity with flexible software options
The unique functionality of waters_connect for quantitation ensures your Xevo TQ Absolute provides absolute productivity. Image Credit: Waters Corporation
Users can choose the best solution for their lab with the modular quantitation software platforms waters_connect and MassLynx.
The modern, app-based software platform waters_connect provides efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality, which can save up to 50% of your data review time and keep the lab as busy as possible. Meanwhile, the tried, well-established MassLynx Software package provides unmatched versatility and flexibility in all application areas.
Maintain peak performance longer with robustness and reproducibility
Minimize contamination and increase uptime with the new source shield technology featured in the Xevo TQ Absolute. Image Credit: Waters Corporation
Analytical laboratories encounter various growing issues; therefore, having complete faith in the analytical instrumentation is vital. The Xevo TQ Absolute was designed primarily to provide consistent robustness and repeatability, maintaining performance and productivity throughout time.
With the Xevo TQ Absolute’s ideal probe positioning assistance, users can achieve peak performance while minimizing contamination and avoiding inconvenient downtime to clean the instrument. The Xevo TQ Absolute’s new source shield can also help the lab increase uptime by reducing source contamination from sample matrix or mobile phase salts.
Accelerating the success with award-winning service
With the help of Waters’ comprehensive analytical solutions, including expert training (APS), trade-ins, technological upgrades (FlexUP), and system service (FlexCHOICE), users can ensure the lab operates effectively and is prepared to take advantage of tomorrow’s opportunities.
Targeted Mass Spectrometry Imaging enables you to simply and quickly access lower limits of detection in molecular visualization directly from surfaces. Image Credit: Waters Corporation
The new generation of Xevo. Image Credit: Waters Corporation
Xevo TQ Absolute Fluidics. Image Credit: Waters Corporation