The BioXplorer 400 is a bench-top, parallel 4 bioreactor platform, typically with 500 ml volume reactors. It is typically utilized in:
- The latter stages of screening / early stages of process development
It has the same design, inputs, and outputs as larger systems, thus facilitating a greater number of investigative variables than a microplate or shake flask, but with an increased number of parallel samples than larger bioreactor systems. This combination of relatively high throughput with high information content enables better decision-making for scale-up and thus can speed up development.
The BioXplorer 400 is available as both a low- and high-pressure variant, enabling access to a wide range of applications ranging from standard gas fermentation and aerobic cultures, to facilitating studies into decarbonizing high-pressure C1 gas fermentation.
Features and Options:
Vessel Types and Volumes/Test Cells
- Reusable glass bioreactors are appropriate for a wide range of applications at atmospheric pressure.
- All reactors are suitable for autoclaving, with auto-cleavable probes as standard.
- Uniquely developed head plates to house all feeds and probes.
- Working volumes ranging from 20 ml to 400 mL.
- Bioreactor geometry that mimics production-scale systems.
- -50 ⁰C to 250 ⁰C as standard (circulator dependent).
- Fine temperature control, with fluctuations normally lower than ±0.05 ⁰C
- Stainless steel reactors for standard or elevated pressure (up to 10 bar/145 PSI) fermentations.
- Through active pumps, manual dip tubes, automated level control, or multisampling units, like the ASU.
- Temperature, pressure, pH, DO, turbidity, conductivity.
- Optional: Integration of third-party probes, such as in-situ FTIR, particle sizing probes, and Raman probes.
- 250 up to 1500 rpm via suspended magnetic agitation.
- 0 up to 1500 rpm via overhead stirring.
- Through fully automated liquid and gas feeds as well as volumetric syringe pumps. These solutions can be applied to both high and low-pressure systems.
- All relevant inputs can be logged, enabling automated monitoring and, where appropriate, feedback control of the reactor system
Intelligent Software Control and Analysis
- The labCONSOL control software from H.E.L operates the BioXplorer 100 system, thereby allowing complicated, completely automated experiments to run without the need to be monitored. This allows:
- Multi reactor control with unrestricted step recipe planning, where plans can be altered at any time without process interruption
- User-defined data logging with customizable tabular and graphical displays
- Starting and stopping reactors simultaneously or individually
- Export data functions and integration with in-house record keeping systems and electronic lab notebooks
- Include automatic user-configurable reaction monitoring and shutdown procedures, to ensure user safety.
- Automatic hardware and software fail-safes are installed on every system.