The BioXplorer 400 has been fitted with four bioreactors along with working volumes of up to 400 mL. It is an ideal tool for parallel bioprocess optimization.

The highly configurable nature of their lid extends the testing capability for the bioprocess, thereby selecting which probes to utilize to specify in real time the vital parameters for the fermentation. Integrated with H.E.L’s WinISO enables the complete automatization of aerobic fermentation.

BioXplorer 400 from H.E.L Group. Image Credit: H.E.L Group


Parallel bioreactor

The BioXplorer 400 features four bioreactors with working volumes ranging from 120 ml to 400 ml, specifically fine-tuned for aerobic fermentation. These bioreactors serve as the cornerstone of the bioprocessing projects, enabling users to conduct up to four parallel bioprocesses simultaneously.

The BioXplorer 400 offers a multitude of options, making it suitable for conducting detailed experiments, parallel screenings, or expediting your research.

Flexibility and control

The extensive range of probes comes with the BioXplorer 400 and allows the tracking of vital parameters for the bioprocess for in-depth characterization. The responsiveness of WinISO enables the accurate control of vital parameters in fermentation via the implementation of automated feedback loops.

BioXplorer 400 is a perfect tool for the characterization and optimization of processes. The customizable configuration of the bioreactors enables for the cautious selection of the parameters to track at the time of fermentation

Users can select between magnetic or overhead agitation in the BioXplorer 400, providing a broader range of impeller speeds. This flexibility allows the user to cultivate shear-sensitive cells at lower speeds, while higher impeller speeds enhance gas transfer for higher cell densities or product yields.

Features and options

Source: H.E.L Group

Specification Point BioXplorer 400
Number of independent parallel bioreactors 4
Bioreactor material Glass body, stainless steel lid
Total volume 500 ml
Working volume 120 – 400 ml
Sterilization Autoclavable bioreactors (including sensors)
Temperature Range 0 – 135 °C
Temperature resolution 0.1 °C
Stirrer drive Magnetically driven captive impeller or Overhead agitation (magnetically coupled)
Stirrer speed
  • Magnetically Driven – 250 – 1500 rpm
  • Overhead Agitation – 20- 2000 rpm
Liquid additions with independent control for each bioreactor 2 as standard, options for upto 2 additional liquid feeds
Gas additions 1 set of 4 mass flow controllers allowing independent control for each reactor as standard, option for 1 additional set
Standard options for MFC calibration Air, oxygen as option
Gas spargers 1
Exhaust gas Peltier cooled condenser
pH control 1-way control (2-way control optional)
Polarographic DO sensing Standard
DO control Gas/liquid flow rate, stirrer speed
BioVIS – Understand cell density trends without taking samples Optional
Foam/Level detection Optional
Control PC and software Windows® PC with WinISO control software preinstalled:
  • Fully independent control of all reactors
  • Advanced control strategies for stirring and liquid and gas additions based on feedback from sensors, time-based profiles, or event detection
  • Real-time display and logging of all reaction parameters
  • Easy export of data in a range of formats, including .csv

* Upper temperature limit for data acquisition from standard pH and DO probes is 60 °C and 40 °C, respectively. The lower temperature limit requires an integrated circulator option. 

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