The BioXplorer 400XL, equipped with eight 500 ml bioreactors, accelerates critical parameter optimization in aerobic fermentations. Its parallel bioprocessing and customizable lid allow real-time parameter selection.

Combined with the WinISO, the BioXplorer 400XL can respond to changes in the bioprocess, allowing for complete automatization of the fermentation process.

BioXplorer 400XL from H.E.L Group. Image Credit: H.E.L Group


Enhanced bioreactor system

The BioXplorer 400XL has eight bioreactors, each optimized for aerobic fermentation and each allowing 120 mL – 400 mL working volume. These bioreactors can be equipped with various probes and sensors, and the system offers multiple gas and liquid feed configurations. The ability to precisely control and monitor up to eight bioprocesses in parallel greatly accelerates screening and optimization studies, leading to more profound process knowledge and faster scale-up.

Flexibility and control

The BioXplorer 400XL integrates larger volumes with the capability of eight independent reactors controlled by WinISO.

This software simultaneously monitors and tightly controls key bioreactor parameters, ensuring ideal conditions are maintained. Combined with customizable options, a versatile range of liquid and gas pumps, and agitation, it offers powerful tools for characterizing and optimizing bioprocesses.

Feature and options

Source: H.E.L Group

Specification Point BioXplorer 400XL
Number of independent parallel bioreactors 8
Bioreactor material Glass body, stainless steel lid
Total volume 500 ml
Working volume 120 – 400 ml
Sterilization Autoclavable bioreactors (including sensors)
Temperature Range 0 – 135 °C
Temperature resolution 0.1 °C
Stirrer drive Magnetically driven captive impeller or Overhead agitation (magnetically coupled)
Stirrer speed
  • Magnetically Driven – 250 – 1500 rpm
  • Overhead Agitation – 20- 2000 rpm
Auto re-couple
  • Magnetically Driven – Yes
  • Overhead Agitation – N/A
Liquid additions with independent control for each bioreactor Magnetically Driven – 2 as standard, options for up to 2 additional liquid feeds
Gas additions 1 set of 8 mass flow controllers allowing independent control for each reactor as standard, option for 1 additional set
Standard options for MFC calibration Air, oxygen as option
Gas spargers 1
Exhaust gas Peltier cooled condenser
pH control 1-way control (2-way control optional)
Polarographic DO sensing Standard
DO control Gas/liquid flow rate, stirrer speed (Optional)
BioVIS – Understand cell density trends without taking samples Optional
Foam/Level detection Optional
Control PC and software Windows® PC with WinISO control software preinstalled:
  • Fully independent control of all reactors
  • Advanced control strategies for stirring and liquid and gas additions based on feedback from sensors, time-based profiles, or event detection
  • Real-time display and logging of all reaction parameters
  • Easy export of data in a range of formats, including .csv

* Upper temperature limit for data acquisition from standard pH and DO probes is 60 ˚C and 40 ˚C, respectively. The lower temperature limit requires an integrated circulator option. 

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