The BioXplorer 400P is an automated parallel pressure bioreactor system that has been designed to help users discover and perfect their innovative bioprocesses. Suitable for a wide array of applications, from syngas fermentation to enzymatically catalyzed processes, it employs precise gas control and pressure to expedite bioprocesses reliant on dissolved gases.

The customizable configuration integrated with adaptable software enables the BioXplorer 400P to satisfy users’ accurate requirements, thereby providing users with the data they need to scale up faster.

BioXplorer 400P from H.E.L Group. Image Credit: H.E.L Group


Pressurized bioprocessing

The BioXplorer 400P stands out due to its capacity to run up to four parallel bioprocesses under pressures of up to 10 bar, a unique feature.

As more bioprocess scientists adopt pressurized systems to enhance the availability of dissolved gases and expedite gas-dependent bioprocesses, the BioXplorer 400P emerges as an essential tool for optimizing and scaling up such processes.

The system prioritizes safety and user-friendliness, exemplified by the use of two gas spargers per reactor, minimizing the risks associated with potentially hazardous gas mixtures. Leveraging pressure to accelerate bioprocesses will enable users to yield higher outputs without compromising functionality and adaptability.

Configurable system

The BioXplorer 400P uses a modular design and can be supplied with a wide range of probes, gas feeds, and liquid feeds, enabling it to be tailored to any user requirements. This helps maximize functionality and ease of use while minimizing bench space requirements and cost.

Flexibility to optimize processes

The selection of probes for monitoring various physicochemical parameters in bioprocesses offers comprehensive insights. Taking advantage of the precise control and responsiveness of H.E.L's WinISO, process automation becomes achievable.

The BioXplorer 400P can also simultaneously operate four bioreactors in parallel or independently, significantly reducing the optimization time required for bioprocesses.

Feature and options

Source: H.E.L Group

Specification Point BioXplorer 400P
Number of independent parallel bioreactors 4
Bioreactor material Glass body, stainless steel lid
Total volume 500 ml
Working volume 120 – 400 ml
Pressure rating Up to 10 bar
Sterilization Autoclavable bioreactors (including sensors)
Temperature Range 0 – 135 °C
Temperature resolution 0.1 °C
Stirrer drive Magnetically driven captive impeller or Overhead agitation (magnetically coupled)
Stirrer speed
  • Magnetically Driven – 250 – 1500 rpm
  • Overhead Agitation – 20- 2000 rpm
Auto re-couple
  • Magnetically Driven – Yes
  • Overhead Agitation – N/A
Liquid additions with independent control for each bioreactor
  • Magnetically Driven – 2 as standard, options for up to 2 additional liquid feeds
  • Overhead Agitation – 2 as standard, option for 1 additional liquid feed
Gas additions 1 set of 4 mass flow controllers allowing independent control for each reactor as standard, option for 2 additional sets
Standard options for MFC calibration Air, oxygen, nitrogen, hydrogen, carbon monoxide, carbon dioxide or methane
Gas spargers 2
Exhaust gas Peltier cooled condenser
pH control 1-way control (2-way control optional)
Polarographic DO sensing Optional
DO control Gas/liquid flow rate, stirrer speed (Optional)
BioVIS – Understand cell density trends without taking samples Optional
Foam/Level detection Optional
Control PC and software Windows® PC with WinISO control software preinstalled:
  • Fully independent control of all reactors
  • Advanced control strategies for stirring and liquid and gas additions based on feedback from sensors, time-based profiles, or event detection
  • Real-time display and logging of all reaction parameters
  • Easy export of data in a range of formats, including .csv

* Upper temperature limit for data acquisition from standard pH probes and optional ORP probes is 130 °C. The optional DO probe measures at temperatures above 135 °C. The lower temperature limit requires an integrated circulator option. 

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