Biochemistry

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Rice U. chemist wins NSF award to investigate how heterogeneity affects chemical and biological processes

Rice University chemist Anatoly Kolomeisky has won an award from the National Science Foundation to investigate how heterogeneity affects chemical and biological processes.

16 Jun 2023

$New facile strategy for proteome analysis using ultracentrifugation fractionation$

New facile strategy for proteome analysis using ultracentrifugation fractionation

Urine is one of the attractive sources for early and sensitive biomarker discovery since it can accumulate and reflect changes in the human body while being collected non-invasively.

16 Jun 2023

Experts identify a novel fucosylated heparan sulfate from the midgut gland of the Japanese scallop

Glycosaminoglycans (GAGs), including chondroitin sulfate (CS), heparan sulfate (HS), heparin, and hyaluronan are linear and acidic polysaccharides found in the extracellular matrix of all animal tissues. GAGs are widely used as functional ingredients in health products, pharmaceuticals, and cosmetics, and are prepared from biological samples such as shark cartilage and porcine intestinal mucosa. Consequently, the demand for new sources of GAGs is ever-present. For example, the supply source of the anticoagulant heparin-;generally prepared from porcine intestinal mucosa in China-;was threatened by African swine fever in 2018.

15 Jun 2023

Noncaloric sweeteners with mineral salt blends give zero- and low-calorie drinks a better flavor

Perfect noncaloric replacements for sugar and high fructose corn syrup just don't exist yet. For example, some alternatives have a lingering sweet aftertaste and lack a sugar-like mouthfeel, leaving consumers unsatisfied.

15 Jun 2023

Silver-doped glass fibers used as a potential treatment for wound healing, finds study

Researchers at the University of Birmingham have demonstrated that silver retains antimicrobial activity for longer when it is impregnated into 'bioactive glass', and shown for the first time how this promising combination delivers more long-lasting antimicrobial wound protection than conventional alternatives.

15 Jun 2023

Breast cancer drug development work moves forward with support from STTR grant

Triple negative breast cancer is an aggressive subtype of breast cancer with worse survival outcomes than most.

14 Jun 2023

New light-responsive membrane transporters for the translocation of peptide cargos inside cells

Crossing the membrane is a major challenge on the journey through the cell. Large biomolecules usually benefit from different transport strategies to overcome the lipid bilayer, so the design and synthesis of new carriers is key for the delivery of hydrophilic substances, such as pharmaceuticals, into the cell.

14 Jun 2023

Psychedelics reopen ‘critical periods’ for social reward learning, mice study shows

Neuroscientists have long searched for ways to reopen "critical periods" in the brain, when mammals are more sensitive to signals from their surroundings that can influence periods of brain development.

14 Jun 2023

Molecule found in the venomous toadfish controls lung inflammation in mice

A molecule found in the venomous toadfish Thalassophryne nattereri has proved capable of controlling lung inflammation and could be the basis for a more effective asthma drug.

13 Jun 2023

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals -; from fuels to fabrics and drugs -; beyond the normal repertoire of microbes.

13 Jun 2023

CHOP researchers engineer stable, universal MHC-I molecules in a shorter timeframe

Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" them to the immune system, which is constantly scanning the body for foreign or toxic antigens.

13 Jun 2023

Heat-damaged DNA in food may contribute to genetic risks

Researchers have newly discovered a surprising and potentially significant reason why eating foods frequently cooked at high temperatures, such as red meat and deep-fried fare, elevates cancer risk. The alleged culprit: DNA within the food that's been damaged by the cooking process.

13 Jun 2023

Researchers create a new method of studying nano-sized particles

Researchers at Karolinska Institutet have created a new method of studying the smallest bioparticles in the body.

12 Jun 2023

Researchers discover how a sugar molecule can affect cancer cell response to chemoradiotherapy

Researchers at Georgetown University's Lombardi Comprehensive Cancer Center and colleagues who have been exploring the complexities of biochemical pathways involved in cancer development have found that a form of glucose, a type of sugar, is intricately linked to a pathway used to build DNA molecules.

12 Jun 2023

New material could usher in the next generation of cancer treatments

A new material, created at the little-explored intersection of organic and inorganic chemistry, could not only enable more powerful solar panels, but it could also usher in the next generation of cancer treatments.

12 Jun 2023

Study reveals how p62 bodies control redox-independent stress response

Cellular stress, or oxidative stress, occurs when there is a buildup of reactive oxygen species (ROS), which interferes with cellular mechanisms and can even cause damage to proteins, lipids, and DNA.

12 Jun 2023

Vaccine against deadly chytrid fungus shifts microbiome to make frogs more resilient to future exposure

A human or animal's microbiome -; the collection of often beneficial microorganisms, including as bacteria and fungi, that live on or within a host organism -; can play an important role in the host's overall immune response, but it is unclear how vaccines against harmful pathogens impact the microbiome.

11 Jun 2023

New method to escape from metastability in a far-from-equilibrium system of DNA-functionalized colloids

Prof. Liang Haojun from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) proposed a new method to escape from metastability for self-assembly in a far-from-equilibrium system.

9 Jun 2023

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors.

8 Jun 2023

Study examines the combined toxicity of common environmental pollutants on the gut-brain axis

Regulating environmental pollution around the world still largely relies upon risk assessments of "single pollutants," ignoring combined toxicities and interactions of groups of substances.

8 Jun 2023

Biochemistry

Rice U. chemist wins NSF award to investigate how heterogeneity affects chemical and biological processes

New facile strategy for proteome analysis using ultracentrifugation fractionation

Experts identify a novel fucosylated heparan sulfate from the midgut gland of the Japanese scallop

Noncaloric sweeteners with mineral salt blends give zero- and low-calorie drinks a better flavor

Silver-doped glass fibers used as a potential treatment for wound healing, finds study

Breast cancer drug development work moves forward with support from STTR grant

New light-responsive membrane transporters for the translocation of peptide cargos inside cells

Psychedelics reopen ‘critical periods’ for social reward learning, mice study shows

Molecule found in the venomous toadfish controls lung inflammation in mice

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

CHOP researchers engineer stable, universal MHC-I molecules in a shorter timeframe

Heat-damaged DNA in food may contribute to genetic risks

Researchers create a new method of studying nano-sized particles

Researchers discover how a sugar molecule can affect cancer cell response to chemoradiotherapy

New material could usher in the next generation of cancer treatments

Study reveals how p62 bodies control redox-independent stress response

Vaccine against deadly chytrid fungus shifts microbiome to make frogs more resilient to future exposure

New method to escape from metastability in a far-from-equilibrium system of DNA-functionalized colloids

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Study examines the combined toxicity of common environmental pollutants on the gut-brain axis

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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