Biochemistry

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Honey enhances probiotic survival in yogurt

If you enjoy a bowl of plain yogurt in the morning, adding a spoonful of honey is a delicious way to sweeten your favorite breakfast food.

5 Aug 2024

Researchers identify strategy to design safer opioids

Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose.

2 Aug 2024

Scientists capture NMDAR protein's 'twist' motion, key to brain signaling

Proteins are constantly performing a kind of dance. They move and contort their bodies to fulfill specific functions inside our bodies. The NMDAR protein executes an especially hard dance routine in our brains. One wrong step can lead to a range of neurological disorders. NMDAR binds to the neurotransmitter, glutamate, and another compound, glycine. These bindings control NMDAR's dance steps. When their routine is over, the NMDAR opens. This open ion channel generates electrical signals critical for cognitive functions like memory.

1 Aug 2024

New zwitterionic polyion developed for effective plasmid DNA delivery in muscle cells

Researchers from Tokyo Metropolitan University have created a new drug delivering molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RNA and proteins.

28 Jul 2024

Study reveals enhanced electron transport in folded peptides

What puts the electronic pep in peptides? A folded structure, according to a new study in the Proceedings of the National Academy of Sciences.

26 Jul 2024

Challenging antibiotic resistance with dual-action macrolones

A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago.

24 Jul 2024

New method can rapidly determine virus infectivity

A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics.

23 Jul 2024

Multi-signal processing guide RNAs: A new frontier in gene regulation

Guides typically assist tourists with directions, but the experience could be greatly enhanced if they offered personalized services tailored to individual interests.

22 Jul 2024

Ginseng genome unlocks secrets of medicinal benefits

A landmark study has successfully decoded the complete ginseng genome, unveiling the genetic mechanisms that govern saponin biosynthesis. This detailed genetic map illuminates the evolutionary and metabolic pathways of Panax ginseng, a staple in traditional medicine. This pivotal discovery promises to drive forward breeding initiatives and augment the plant's medicinal qualities, unlocking new possibilities for therapeutic applications.

19 Jul 2024

New insights into modified nucleoside synthesis

The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis system.

19 Jul 2024

Discovery of over 1,000 undetected proteins in metabolite samples

Van Andel Institute scientists have identified more than 1,000 previously undetected proteins in common metabolite samples, which persist despite extraction methods designed to weed them out.

18 Jul 2024

Innovative approaches in polymer nanoparticle synthesis for RNA therapeutics

RNA therapy with polymer nanoparticles is considered a promising approach for the treatment of various illnesses.

15 Jul 2024

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

Dispen3D is setting new standards in single-cell biology, enabling researchers to conduct high-precision experiments that drive advancements in drug discovery, personalized medicine, and regenerative therapies.

From SEED Biosciences 12 Jul 2024

Enzymatic RNA synthesis paves the way for sustainable therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

12 Jul 2024

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

Imagine a scenario where a skilled hacker must upload critical software to update a central server and thwart a potentially lethal virus from wreaking havoc across a vast computer network.

10 Jul 2024

Trinity College Dublin researchers uncover key to enhancing MRSA vaccine efficacy

Researchers from Trinity College Dublin have taken a leap forward in understanding how we might fight back against the potentially deadly MRSA bacterium.

9 Jul 2024

Exploring PRM-A as a novel glycan-targeted therapy for SARS-CoV-2 inhibition

HIV, Ebola and most recently, COVID-19 viruses have had an enormous impact on our societies world-wide.

4 Jul 2024

Research could help drug developers improve the safety profiles of medications

Research from the University of British Columbia, MIT, and the University of Michigan could help drug developers improve the safety profiles of medications and reduce side effects.

3 Jul 2024

GCARDTI: Advancing drug-target interaction prediction with hybrid graph learning

The identification of drug-target Interactions (DTIs) represents a pivotal link in the process of drug development and design.

2 Jul 2024

Key transcription factor enhances anthocyanin production in wounded grapevines

A recent study sheds light on the biochemical response of grapevines to wounding stress. It reveals that the transcription factor VvWRKY5 is a key regulator that enhances anthocyanin production, which serves as a protective mechanism for the plant.

2 Jul 2024