Biochemistry

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Short-chain fatty acids play a beneficial role in the gut-lung axis of aging mice

The gut microbial community structure-; communities of bacteria, viruses and fungi that live in the intestines-; influences the inflammatory response in the lungs of aging mice, according to researchers from the Institute of Functional Anatomy at Charité, the Medical University of Berlin in Germany.

25 May 2023

Oxygen restriction associated with longer lifespan in lab mice

For the first time, researchers have shown that reduced oxygen intake, or "oxygen restriction", is associated with longer lifespan in lab mice, highlighting its anti-aging potential.

24 May 2023

Looking at cancer drugs to help put the brakes on classic indicators of aging

Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.

24 May 2023

$Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride$

Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride

For pharmaceuticals, knowing the chemical composition is not enough-;molecular geometry and crystal structure also play an important role in a drug's activity.

23 May 2023

Honokiol inhibits replication of SARS-CoV-2 in several cell types

A compound called honokiol, which is found in the bark of multiple species of magnolia tree, inhibits replication of SARS-CoV-2 virus in several types of cells, according to a team of researchers in the Netherlands.

22 May 2023

Exploring how and why nitrate has contrasting potential risks and benefits

Despite our understanding of nutrition expanding remarkably in recent times, few aspects of our diet continue to confuse and divide the experts like nitrate.

22 May 2023

Researchers receive $2.3 million to continue development of a new ‘glyco-immune’ checkpoint inhibitor

Researchers from Rice University and Baylor College of Medicine are hoping a first-of-its-kind "glyco-immune" checkpoint inhibitor could be the key to stopping bone cancer metastasis for breast cancer survivors.

19 May 2023

Low-cost, recyclable powder uses sunlight to kill thousands of waterborne bacteria

At least 2 billion people worldwide routinely drink water contaminated with disease-causing microbes.

18 May 2023

Researchers discover how corticosteroids influence inflammatory response during COVID-19 infection

Since the start of the COVID-19 pandemic, a class of corticosteroids called glucocorticoids (GCs) have become established as one of the main treatment options, especially for severe cases, thanks to their anti-inflammatory and immunosuppressant action.

18 May 2023

Melanin structure discovery brings scientists one step closer to developing ultra-protective sunscreen

A new discovery about the structure of melanin has brought scientists one step closer to developing a new, potentially ultra-protective sunscreen derived from a biological substance found in nearly all organisms.

18 May 2023

NIR spectroscopy offers fast, easy, inexpensive way to detect food allergens

Food allergies pose a significant health risk, resulting in numerous hospitalizations every year, as even trace amounts of allergens can trigger severe reactions.

18 May 2023

Using synthetic peptides for inflammatory disease diagnosis

Scientists have developed a peptide that binds to the protein calprotectin, a marker of major inflammatory disorders, and shown that it is suitable for diagnostic tests.

17 May 2023

Study establishes a mechanistic link between obesity and oral cancer immune escape

A team from the University of Michigan Rogel Cancer Center and School of Dentistry, led by Yu Leo Lei, D.D.S., Ph.D., have identified a mechanism in mice for how obesity affects some oral cancers' ability to escape from the immune system.

16 May 2023

Researchers discover how the A. baumannii can survive harsh environments

The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body's built-in infection-fighting response.

16 May 2023

New SEISMIC facility could improve our understanding of infectious diseases, aging and cancers

A new national research facility could significantly improve our understanding of infectious diseases, aging and cancers, leading to novel treatments and vaccines.

16 May 2023

Research sheds light on potential application of cyclodextrin derivatives in drug-supersaturated formulations

In the medicine market, most newly introduced drugs and drug candidates show poor water solubility, which prevents their absorption in the body.

15 May 2023

Weight loss leads to an increase in skeletal muscle mitochondrial energy production efficiency

Weight regains is a common problem for weight loss individuals. A number of studies have shown that weight loss in overweight people results in a reduction in whole-body energy expenditure.

15 May 2023

Phosphatases of regenerating liver play a unique role in the growth and spread of cancers

Phosphatases of regenerating liver (PRLs) are a family of enigmatic proteins involved in cell growth and metabolism present in various species.

15 May 2023

New compound with antibacterial activity shows promising results within one hour in laboratory trials

Resistance to antibiotics is a problem that alarms the medical and scientific community. Bacteria resistant to three different classes of antibiotics, known as multi-drug resistant (MDR) bacteria, are far from rare.

15 May 2023

Creating the Lab of the Future; What does it entail?

As part of our SLAS US 2023 coverage, we speak to Luigi Da Via, Team Leader in Analytical Development at GSK, about the lab of the future, and what it may look like.

From Society for Laboratory Automation and Screening (SLAS) 15 May 2023

Biochemistry

Short-chain fatty acids play a beneficial role in the gut-lung axis of aging mice

Oxygen restriction associated with longer lifespan in lab mice

Looking at cancer drugs to help put the brakes on classic indicators of aging

Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride

Honokiol inhibits replication of SARS-CoV-2 in several cell types

Exploring how and why nitrate has contrasting potential risks and benefits

Researchers receive $2.3 million to continue development of a new ‘glyco-immune’ checkpoint inhibitor

Low-cost, recyclable powder uses sunlight to kill thousands of waterborne bacteria

Researchers discover how corticosteroids influence inflammatory response during COVID-19 infection

Melanin structure discovery brings scientists one step closer to developing ultra-protective sunscreen

NIR spectroscopy offers fast, easy, inexpensive way to detect food allergens

Using synthetic peptides for inflammatory disease diagnosis

Study establishes a mechanistic link between obesity and oral cancer immune escape

Researchers discover how the A. baumannii can survive harsh environments

New SEISMIC facility could improve our understanding of infectious diseases, aging and cancers

Research sheds light on potential application of cyclodextrin derivatives in drug-supersaturated formulations

Weight loss leads to an increase in skeletal muscle mitochondrial energy production efficiency

Phosphatases of regenerating liver play a unique role in the growth and spread of cancers

New compound with antibacterial activity shows promising results within one hour in laboratory trials

Creating the Lab of the Future; What does it entail?

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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