Genomics

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Novel splicing mechanism for short introns discovered

Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been uncovered.

15 Feb 2024

New epigenetic clocks distinguish aging causes and effects

What causes us to age? New "clocks" developed by researchers may help point to the answers. Investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, unveil a new form of epigenetic clock – a machine learning model designed to predict biological age from DNA structure.

14 Feb 2024

Study reveals genes crucial for protecting male fertility

Discovery of a pair of genes that work in perfect harmony to protect male fertility, could provide new insights into some unexplained cases of the most severe form of infertility, research suggests.

14 Feb 2024

Study uncovers more than one hundred key genes linked to DNA damage

More than one hundred key genes linked to DNA damage have been uncovered through systematic screening of nearly 1,000 genetically modified mouse lines, in a new study published today (14 February) in Nature.

14 Feb 2024

Phosphoproteomic profiling reveals the complex interplay of immune cells in tumors

Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field.

14 Feb 2024

Breakthrough research unveils effects of ionizing radiation on cellular DNA

Recent release of the waste water from Japan's Fukushima nuclear disaster stirred apprehension regarding the health implications of radiation exposure.

14 Feb 2024

Genes dictate taste: Study finds genetic links to food preferences

Study reveals the significant impact of genetic variations on adult dietary preferences, highlighting the complex interplay between genetics and food choices.

13 Feb 2024

Novel assay enhances pediatric cancer treatment by identifying clinically relevant gene fusions

Identification of specific gene fusions is critical for the successful targeted treatment of pediatric cancer patients.

13 Feb 2024

Gene editing gets a boost with new CRISPR-COPIES

CRISPR/Cas systems have undergone tremendous advancement in the past decade. These precise genome editing tools have applications ranging from transgenic crop development to gene therapy and beyond.

12 Feb 2024

Understanding how natural genetic variation contributes to adaptive responses to low oxygen

Humans are still evolving, and Tatum Simonson, PhD, founder and co-director of the Center for Physiological Genomics of Low Oxygen at University of California School of Medicine, plans to use evolution to improve healthcare for all.

12 Feb 2024

Breakthrough technique unveils secrets of "backtracking" in gene regulation

A technique can determine for the first time how frequently, and exactly where, a molecular event called "backtracking" occurs throughout the genetic material (genome) of any species, a new study shows.

9 Feb 2024

DDT exposure found to alter sperm epigenome in humans

In a study that signals potential reproductive and health complications in humans, now and for future generations, researchers from McGill University, the University of Pretoria, Université Laval, Aarhus University, and the University of Copenhagen, have concluded that fathers exposed to environmental toxins, notably DDT, may produce sperm with health consequences for their children.

9 Feb 2024

Decoding the differences between two vital RNA transport complexes

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.

8 Feb 2024

Never-before-documented genetic disorder causes rare lung disease

The macrophage is one of the body's most important inhabitants. Meaning "big eater" in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris.

8 Feb 2024

Parental traits offer new clues to predicting neurodevelopmental disorders in children

Predicting the trajectory of neurodevelopmental and psychiatric disorders like autism or schizophrenia is difficult because they can be influenced by many different genetic and environmental factors.

8 Feb 2024

Researchers develop new approach to improve the accuracy of RNA sequencing

A team at NDORMS, University of Oxford has developed a new approach to significantly improve the accuracy of RNA sequencing.

7 Feb 2024

Extra fingers and double hearts: Scientists decode how tiny mutations can derail development

Our genomes provide the instructions for proper growth and development. Millions of genomic switches, known as enhancers, control the location and timing of gene expression, which in turn ensures the correct proteins are made in the right cells at the right time throughout our lives.

6 Feb 2024

Researchers discover mechanism that protects tissue after faulty gene expression

The genetic material, in the form of DNA, contains the information that is crucial for the correct functioning of every human and animal cell.

2 Feb 2024

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in "Science Immunology."

2 Feb 2024

Breakthrough recombinase technology ushers in precise, adaptable gene editing

A team of researchers at the Carl Gustav Carus Faculty of Medicine, TUD Dresden University of Technology, led by Prof. Frank Buchholz, has achieved a major breakthrough in genome editing technology.

1 Feb 2024

Genomics

Novel splicing mechanism for short introns discovered

New epigenetic clocks distinguish aging causes and effects

Study reveals genes crucial for protecting male fertility

Study uncovers more than one hundred key genes linked to DNA damage

Phosphoproteomic profiling reveals the complex interplay of immune cells in tumors

Breakthrough research unveils effects of ionizing radiation on cellular DNA

Genes dictate taste: Study finds genetic links to food preferences

Novel assay enhances pediatric cancer treatment by identifying clinically relevant gene fusions

Gene editing gets a boost with new CRISPR-COPIES

Understanding how natural genetic variation contributes to adaptive responses to low oxygen

Breakthrough technique unveils secrets of "backtracking" in gene regulation

DDT exposure found to alter sperm epigenome in humans

Decoding the differences between two vital RNA transport complexes

Never-before-documented genetic disorder causes rare lung disease

Parental traits offer new clues to predicting neurodevelopmental disorders in children

Researchers develop new approach to improve the accuracy of RNA sequencing

Extra fingers and double hearts: Scientists decode how tiny mutations can derail development

Researchers discover mechanism that protects tissue after faulty gene expression

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Breakthrough recombinase technology ushers in precise, adaptable gene editing

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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