Genomics

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Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms

Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients through a collaboration with Boston Children's Hospital.

7 Nov 2025

Genomic mapping of resistance mutations in A. baumannii

The bacteria Acinetobacter baumannii (A. baumannii) is a haunting presence in many hospitals in the United States, where more than one in 100 patients are treated for A. baumannii infections.

7 Nov 2025

Researchers refine tools to map DNA’s 3D structure inside cells

DNA isn't just a long string of genetic code, but an intricate 3D structure folded inside each cell. That means the tools used to study DNA need to be just as sophisticated-able to read not only the code itself, but how it's arranged in space.

6 Nov 2025

Scientists map gut microbiota associated with coronary artery disease

Nearly 20 million people die every year from cardiovascular diseases, the leading cause of death worldwide.

6 Nov 2025

Scientists identify essential process that protects DNA integrity in reproductive cells

A team of scientists at the University of Seville has identified an essential process that protects DNA integrity in reproductive cells, providing new clues about how organisms avoid genetic defects during egg formation.

6 Nov 2025

Two main methods for discovering disease genes reveal distinct aspects of biology

The two main approaches for discovering disease genes reveal distinct aspects of biology, a new study shows. While both methods are widely used, the research found that they identify different genes, with major implications for drug development.

6 Nov 2025

Maternal type 1 diabetes confers a protective effect in children through epigenetic programming

Children with a family history of type 1 diabetes (T1D) have an increased risk of developing the disease.

6 Nov 2025

New genomic method unlocks hidden diversity in ocean microbes and viruses

A new method vastly improves on the existing approach for single-cell genetic sequencing, enabling scientists to read the genomes of individual cells and viral particles in the environment more quickly, efficiently, and cost-effectively.

5 Nov 2025

USC-led study advances understanding of prostate cancer genetics in Black men

New prostate cancer research from an international team led by the Center for Genetic Epidemiology at the Keck School of Medicine of USC has yielded discoveries that could improve screening and treatment for patients of African ancestry.

5 Nov 2025

SPT Labtech and Alithea Genomics collaborate to automate ultra sensitive single-cell transcriptomic workflows

SPT Labtech, a global leader in the design and development of laboratory automation and liquid handling solutions, and Alithea Genomics, a pioneer in the field of large-scale RNA sequencing and transcriptomics, today announced a collaboration to provide an automated solution for single-cell transcriptomics.

5 Nov 2025

PTGES3 emerges as key regulator of androgen receptor in prostate cancer

A poorly characterized protein, historically thought to be a chaperone or enzyme, may actually be a key player in prostate cancer.

5 Nov 2025

USC researchers map genetic architecture of the human corpus callosum

For the first time, a research team led by the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has mapped the genetic architecture of a crucial part of the human brain known as the corpus callosum-the thick band of nerve fibers that connects the brain's left and right hemispheres.

4 Nov 2025

Stress hormones may silence crucial neuronal genes through specific RNA molecules

What if the brain's response to stress could be read not in fleeting neurotransmitter bursts, but in the quieting of genes deep inside chromatin? Researchers at the University of Alabama at Birmingham have now shown that stress hormones may silence crucial neuronal genes through an unexpected class of RNA molecules that operate not by encoding proteins, but by reshaping the genome's architecture.

4 Nov 2025

Researchers develop a versatile tool for controlling gene activity

Investigators at Weill Cornell Medicine have developed a versatile and non-toxic technology for controlling the activity of any gene in a cell. Such "gene-switch" tools allow scientists to "turn on" or "turn off" a target gene to study how it works, model diseases and design new therapies.

3 Nov 2025

New genomic method enables multiple people with rare conditions to receive diagnoses

A new genomic method has enabled multiple people with rare conditions to receive diagnoses that were previously unattainable by identifying complex structural genetic changes that are often missed by standard tests.

3 Nov 2025

Dysfunction in chromosome-stabilizing protein identified as a cause of deadly illnesses

New research from the University of Wisconsin–Madison reveals that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious - and sometimes deadly - diseases.

31 Oct 2025

Neuroscientists uncover a surprising role for "Frazzled" protein in the nervous system of fruit flies

Florida Atlantic University neuroscientists have uncovered a surprising role for a protein named "Frazzled" (known as DCC in mammals) in the nervous system of fruit flies, showing how it helps neurons connect and communicate with lightning speed.

31 Oct 2025

Genetic insights into vestibular system damage from ototoxic drugs

The vestibular system is responsible for the sense of balance in the inner ear. Prolonged use of toxic substances, such as certain antibiotics or anticancer drugs, can damage the hair cells that form part of this system, leading to alterations in balance and other motor skills.

31 Oct 2025

Breakthrough study maps impact of thousands of variants in heart disease gene

An international research consortium co-led by scientists from Vanderbilt University Medical Center, the University of Toronto and University of Pittsburgh has mapped the functional impact of more than 17,000 variants in a major gene associated with the development of premature atherosclerotic heart disease.

31 Oct 2025

Massive cross-ancestry study explains why obesity risks differ around the world

A massive cross-ancestry genetic study involving over 839,000 adults identified 13 genes linked to obesity, including five never before associated with the condition. The findings highlight how global genetic diversity can uncover new biological pathways and potential treatment targets for obesity.

31 Oct 2025

Genomics

Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms

Genomic mapping of resistance mutations in A. baumannii

Researchers refine tools to map DNA’s 3D structure inside cells

Scientists map gut microbiota associated with coronary artery disease

Scientists identify essential process that protects DNA integrity in reproductive cells

Two main methods for discovering disease genes reveal distinct aspects of biology

Maternal type 1 diabetes confers a protective effect in children through epigenetic programming

New genomic method unlocks hidden diversity in ocean microbes and viruses

USC-led study advances understanding of prostate cancer genetics in Black men

SPT Labtech and Alithea Genomics collaborate to automate ultra sensitive single-cell transcriptomic workflows

PTGES3 emerges as key regulator of androgen receptor in prostate cancer

USC researchers map genetic architecture of the human corpus callosum

Stress hormones may silence crucial neuronal genes through specific RNA molecules

Researchers develop a versatile tool for controlling gene activity

New genomic method enables multiple people with rare conditions to receive diagnoses

Dysfunction in chromosome-stabilizing protein identified as a cause of deadly illnesses

Neuroscientists uncover a surprising role for "Frazzled" protein in the nervous system of fruit flies

Genetic insights into vestibular system damage from ototoxic drugs

Breakthrough study maps impact of thousands of variants in heart disease gene

Massive cross-ancestry study explains why obesity risks differ around the world

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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