Genomics

RSS

Gene therapy for rare diseases: A decade of progress and remaining challenges

A new review article in the peer-reviewed journal Human Gene Therapy summarizes the significant milestones in the development of gene therapy medicinal products that have facilitated the treatment of a significant number of rare diseases.

14 Nov 2023

Circular extrachromosomal DNA identified as a potential target for new medulloblastoma therapies

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA - loops of DNA found outside of regular chromosomes - are twice as likely to relapse and three times as likely to die within five years of diagnosis.

14 Nov 2023

COVID-19 triggers epigenetic alterations that drive lung damage and fatalities

The COVID-19 disease, due to infection with the SARS-CoV2 virus, became an international pandemic in 2020. To date, more than 770 million people have suffered from the disease and nearly 7 million of them have lost their life.

14 Nov 2023

Traffic emissions disrupt gene expression in human olfactory cells

Exposure to ultrafine particles from traffic alters the expression of many genes in human olfactory mucosa cells, a new study shows.

14 Nov 2023

Genetic test for antidepressants could save millions and improve patient outcomes

A special kind of genetic test that helps determine the best antidepressant for patients with moderate-to-severe depression could generate substantive health system savings and greatly improve patient outcomes, according to new research from the University of British Columbia.

14 Nov 2023

New study identifies 4,749 key gene clusters that influence progression of 32 cancer types

Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed "prognostic modules," that significantly influence the progression of 32 different types of cancer.

13 Nov 2023

New research aims to decipher how animals discard half their genes

New research is underway to decipher a fascinating biological puzzle - how some animals can naturally discard more than half of their genetic information during embryonic development.

9 Nov 2023

Study compiles the most comprehensive list of genetic variants associated with prostate cancer risk

A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk - 451 in all - through a whole-genome analysis that ranks as the largest and most diverse investigation into prostate cancer genetics yet.

9 Nov 2023

Genetic melting pot: Study unveils complex admixture in European ancestry populations

In a recent Nature Communications study, researchers revealed that Europeans and European Americans possess a significant subcontinental genetic admixture, challenging the notion that these populations are homogenous. This finding suggests the need to re-evaluate genetic epidemiology studies that may have overlooked the influence of admixture on disease associations and trait heritability in these groups.

8 Nov 2023

Study finds 4% of Icelanders to carry an actionable genotype associated with shortened lifespan

Scientists at deCODE genetics, a subsidiary of Amgen, have published a study on actionable genotypes detected in the Icelandic population and their association with lifespan.

8 Nov 2023

Can adding RNA sequencing to germline genetic testing improve accuracy and clinical sensitivity over time compared to DNA sequencing alone?

Concurrent sequencing of DNA and RNA to detect the predisposition to hereditary cancer.

8 Nov 2023

Study provides insights into the epidemiology and genetics of clonal hematopoiesis

A comprehensive new study from deCODE genetics, a subsidiary of Amgen, published today in Nature Genetics, provides insights into the epidemiology and somatic and germline genetics of clonal hematopoiesis.

7 Nov 2023

Enhanc3D Genomics expands leadership team with the appointment of Hazel Jones as Chief Operating Officer

Enhanc3D Genomics today announced the appointment of Hazel Jones as Chief Operating Officer.

6 Nov 2023

Individuals with genetic predisposition for physical activity have fewer cardiovascular risk factors

In a study conducted at the University of Jyväskylä's Faculty of Sport and Health Sciences, it was found that individuals with a genetic predisposition for higher levels of physical activity have fewer risk factors for cardiovascular diseases and a reduced risk of developing hypertension, cerebrovascular diseases, and type 2 diabetes.

6 Nov 2023

Genomics

Gene therapy for rare diseases: A decade of progress and remaining challenges

Circular extrachromosomal DNA identified as a potential target for new medulloblastoma therapies

COVID-19 triggers epigenetic alterations that drive lung damage and fatalities

Traffic emissions disrupt gene expression in human olfactory cells

Genetic test for antidepressants could save millions and improve patient outcomes

New study identifies 4,749 key gene clusters that influence progression of 32 cancer types

New research aims to decipher how animals discard half their genes

Study compiles the most comprehensive list of genetic variants associated with prostate cancer risk

Genetic melting pot: Study unveils complex admixture in European ancestry populations

Study finds 4% of Icelanders to carry an actionable genotype associated with shortened lifespan

Can adding RNA sequencing to germline genetic testing improve accuracy and clinical sensitivity over time compared to DNA sequencing alone?

Study provides insights into the epidemiology and genetics of clonal hematopoiesis

Enhanc3D Genomics expands leadership team with the appointment of Hazel Jones as Chief Operating Officer

Individuals with genetic predisposition for physical activity have fewer cardiovascular risk factors

Telomouse model provides a valuable resource for in-depth aging and cancer research

New study unveils Foxp3's role in regulatory T cell chromatin architecture

Time-lapsed images show how magnesium ions coordinate double-stranded breaks in CRISPR-Cas9

Study reveals how formaldehyde alters gene expression through epigenetics

Gene discovery sheds light on ovary development

Scientists decode genetic programs controlling sex-specific organ development

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

Latest Life Science News