Histology & Microscopy

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New technology maps molecules within single cells to uncover disease mechanisms

Tissues consist of a heterogenous mixture of different cell types, complicating our understanding of their biological functions and studies of disease.

14 May 2025

Scientists capture first real time images of heart formation in mouse embryos

Researchers at UCL and the Francis Crick Institute have, for the first time, identified the origin of cardiac cells using 3D images of a heart forming in real-time, inside a living mouse embryo.

13 May 2025

Advanced microscopy reveals how hormonal fluctuations shape the brain

Hormone levels fluctuate like the tides, ebbing and flowing according to carefully orchestrated cycles.

13 May 2025

Researchers uncover how Entamoeba histolytica evades the immune system

The single-celled parasite Entamoeba histolytica infects 50 million people each year, killing nearly 70,000. Usually, this wily, shape-shifting amoeba causes nothing worse than diarrhea.

12 May 2025

Uncovering the architecture of the human sugar sensor

Our attraction to sugar has grown to an unhealthy level. The average person in the United States now consumes more than 100 pounds of the sweet stuff every year, up from 18 pounds in 1800.

7 May 2025

Synthetic tau protein reveals key insights into protein misfolding and fibril formation

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion.

29 Apr 2025

PET scans reveal early signs of Parkinson’s and Lewy body disorders

In a comprehensive Genomic Press perspective article published today, researchers from Fudan University and Shanghai University of Traditional Chinese Medicine have highlighted remarkable advances in the development of positron emission tomography (PET) tracers capable of visualizing α-synuclein aggregates in the brains of patients with Parkinson's disease and related disorders.

29 Apr 2025

Researchers create detailed 3D map of parasite behind sleeping sickness

Millions of people worldwide are affected by African sleeping sickness, Chagas disease and other life-threatening infections caused by microscopic parasites borne by insects such as the tsetse fly.

23 Apr 2025

New expansion technique brings mass spectrometry imaging to single cell level

For biologists, seeing is believing. But sometimes biologists have a hard time seeing.

22 Apr 2025

Mitochondrial pyruvate carrier structure solved after fifty years

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a process vital to all life on Earth.

18 Apr 2025

Nuclera expands eProtein Discovery capabilities to enable membrane protein production

Nuclera, the biotechnology company accelerating protein expression and optimization through its benchtop eProtein Discovery™ system, today announced the addition of a new membrane protein workflow to its system.

From Nuclera 16 Apr 2025

New method detects and quantifies nanoplastics in transparent body fluids

Microplastics and the much smaller nanoplastics enter the human body in various ways, for example through food or the air we breathe.

14 Apr 2025

Bacteria engineered for remote sensing through color signatures

Bacteria can be engineered to sense a variety of molecules, such as pollutants or soil nutrients. In most cases, however, these signals can only be detected by looking at the cells under a microscope or similarly sensitive lab equipment, making them impractical for large-scale use.

11 Apr 2025

New insights into how myasthenia gravis antibodies disrupt muscle function

People who suffer from the autoimmune disease myasthenia gravis experience muscle weakness that can affect any of the muscles we use to blink, smile or even move our body around.

9 Apr 2025

Cryo-EM reveals fine structural details of human chromatin remodeler in action

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases.

4 Apr 2025

Scientists discover cellular mechanism to protect and repair mitochondria

Damage to the genetic material of mitochondria – the mitochondrial DNA or mtDNA for short – can lead to diseases such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis (ALS), cardiovascular diseases and type 2 diabetes.

4 Apr 2025

Scientists unveil dynamic structure of protein key to vision

Scientists have for the first time looked deep into the protein structure that may determine our vision - and discovered that it is much more dynamic than previously thought.

4 Apr 2025

New imaging method captures cells in 3D within whole organs

While medical centers use ultrasound daily, so far this technology is not capable of observing body tissues at the scale of cells.

4 Apr 2025

New insights into how glutamate opens brain cell signaling channels

In an effort to understand how brain cells exchange chemical messages, scientists say they have successfully used a highly specialized microscope to capture more precise details of how one of the most common signaling molecules, glutamate, opens a channel and allows a flood of charged particles to enter.

28 Mar 2025

New phospholipids improve functional mRNA delivery via lipid nanoparticles

Researchers develop innovative phospholipids that improve the functional delivery of mRNA via lipid nanoparticles, paving the way for advanced therapeutic applications.

28 Mar 2025