Histology & Microscopy

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Ohio State study unlocks the long-standing mystery of RNA interference

While scientists have known for over two decades that all cells use a strategy called RNA interference to regulate gene expression, a new study is the first to describe how a specific protein manages the step-by-step process of assembling the molecular complex that performs the regulatory job.

26 May 2026

Smaller tetraploid cells drive more aggressive cancer

Megan Sweet slices tumors. A normal day in the lab finds the Virginia Tech graduate student with hands deep inside a refrigerated metal box, pulling a mounted mouse-grown tumor incrementally closer to a razor-sharp blade.

25 May 2026

Scientists visualize a key cell protein regulating inflammatory disease pathways

University of Cincinnati structural biologists are the first in the world to visualize a key cell protein as part of newly published research from the College of Medicine.

22 May 2026

Scientists capture immune cells attacking live melanoma cells in real time

Scientists at the Garvan Institute of Medical Research have captured, for the first time, 'housekeeping' immune cells actively attacking and engulfing live melanoma cells – a discovery that could change the way we approach treatment for one of Australia's most common and deadly cancers.

21 May 2026

Neuroplex pipeline monitors nine neuronal populations in moving mice

Scientists at the Max Planck Florida Institute for Neuroscience (MPFI), in collaboration with ZEISS and MetaCell, have developed a powerful new imaging pipeline called Neuroplex.

20 May 2026

Fluid viscosity drives mechanical memory and invasion in glioblastoma

Most cancer studies focus on chemical signals or stiff tumor surroundings, but the stickiness of the fluid itself has received little attention.

20 May 2026

AI-based generative framework create all-atom models of proteins in motion

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins. When molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

13 May 2026

KIT researchers develop contact-free laser technique to rotate microscopic samples

Until now, it has been technically nearly impossible to rotate highly sensitive samples in all directions under a microscope without making contact.

12 May 2026

Atomic-level images could improve future COVID-19 antiviral drug design

The closest-ever detailed look at a key enzyme inside the virus that causes COVID-19 could lead to more effective treatment of the disease.

10 May 2026

Cryo-electron microscopy offers an unprecedented view of gene transcription

The enzyme RNA polymerase (RNAP) carries out transcription, copying DNA into RNA. It's the first step in gene expression, and a process fundamental to all life.

30 Apr 2026

Cryo-expansion microscopy reveals three-dimensional organization of killer T cells

Cytotoxic T lymphocytes are the body's specialized "killer" cells, precisely eliminating infected or cancerous cells.

29 Apr 2026

Detailed images reveal DNA repair mechanism in cancer-related proteins

Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a finding that could reveal ways to inhibit the effects of BRCA1 and BRCA2 mutations that heighten the risk for breast, ovarian and other cancers.

28 Apr 2026

New cytometer measures cell stiffness to improve disease diagnosis

Researchers from Brown University and their collaborators have developed a new way to measure the properties of cells - an important development, they say, because accurate measurements of changes in cell elasticity can be used to better understand diseases, diagnose patient symptoms and provide more accurate prognoses.

25 Apr 2026

Epigenome proteins shape dynamic gene expression beyond simple on-off

A new study finds the proteins responsible for controlling which genes are expressed in a genome do more than simply turn a gene on or off.

21 Apr 2026

New imager separates UV and infrared light to find cancerous nodes

Researchers have developed a compact camera that captures ultraviolet, near-infrared and visible images using a single chip. Inspired by the multiwavelength vision capability of the mantis shrimp, the camera could help surgeons identify lymph nodes connected to a tumor and assess whether cancer has spread to them, making cancer surgery safer and less invasive.

17 Apr 2026

New imaging technique captures ultrafast microscopic processes with unprecedented detail

Researchers have developed a new imaging technique that captures more information about ultrafast processes in the microscopic world than was previously possible.

10 Apr 2026

Dynamic binding of linker histone H1 shapes flexible chromatin organization

DNA inside the nucleus is not packed as a rigid regular fiber-linker histone H1 dynamically binds and loosely "glues" nucleosomes together, creating a dynamic, fluid organization that can still support essential genome functions.

9 Apr 2026

Study reveals bile as reservoir for microplastics in humans

Plastic pollution has become one of the defining environmental issues of modern life, and microplastics are now known to enter the body through food, drink, and air.

6 Apr 2026

Deep UV microscopy enables label-free T cell characterization

A team of researchers at the Georgia Institute of Technology and Emory University has developed a deep-ultraviolet (UV) microscopy method that can rapidly assess T cell viability, activation state, and subtype-all without the need for fluorescent labels or cell destruction.

3 Apr 2026

Study reveals pearling mechanism behind mitochondrial DNA spacing

Mitochondria are often described as the cell's power plants, because they generate energy. To help them achieve this, mitochondria carry their own small genome called mitochondrial DNA (mtDNA).

2 Apr 2026