Histology & Microscopy

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Structural insights into IVD enzyme function and isovaleric acidemia

IVD is a key enzyme in leucine catabolism, catalyzing the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.

10 Jun 2025

Electron microscopy study shows how two enzymes work in tandem to process proteins

Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, because they unravel proteins tagged for destruction or recycling.

6 Jun 2025

Innovative method reveals how titin disruption triggers muscular diseases

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), led by Jorge Alegre-Cebollada, has developed an innovative method, called TEVs-TTN, for studying the specific mechanical functions of proteins through their controlled cleavage, a process that renders the proteins unable to sense and transmit mechanical force.

5 Jun 2025

New cryogenic mass spectrometry approach reveals inner structure of lipid nanoparticles

Scientists have developed a method for analysing the structure of lipid nanoparticles that could be used to improve vaccine and drug delivery, targeting a wide range of health issues.

23 May 2025

Confocal microscopy may help identify biomarkers for chemotherapy-induced neuropathy

A University of Arizona Comprehensive Cancer Center researcher received a $2.4 million National Cancer Institute grant to develop a noninvasive, confocal microscope to examine nerve endings of cancer patients with chemotherapy-induced peripheral neuropathy in the hopes of identifying potential biomarkers for the disease.

22 May 2025

New technique rapidly tracks cell state changes through density measurements

Measuring the density of a cell can reveal a great deal about the cell's state. As cells proliferate, differentiate, or undergo cell death, they may gain or lose water and other molecules, which is revealed by changes in density.

21 May 2025

Cell Painting technology uncovers flavonoids with potential to treat bladder cancer

A team led by researchers at Baylor College of Medicine has identified flavonoids, natural compounds found in plants, that are toxic to bladder cancer cells cultured in the lab.

20 May 2025

Age-related immune decline reduces CAR-T cell therapy efficacy

As people age, their immune systems become less efficient, posing a challenge for cancer therapies that rely on harnessing immune cells.

20 May 2025

New stem cell model replicates human amniotic sac development

Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four weeks after fertilization.

15 May 2025

New technology maps molecules within single cells to uncover disease mechanisms

Tissues consist of a heterogenous mixture of different cell types, complicating our understanding of their biological functions and studies of disease.

14 May 2025

Scientists capture first real time images of heart formation in mouse embryos

Researchers at UCL and the Francis Crick Institute have, for the first time, identified the origin of cardiac cells using 3D images of a heart forming in real-time, inside a living mouse embryo.

13 May 2025

Advanced microscopy reveals how hormonal fluctuations shape the brain

Hormone levels fluctuate like the tides, ebbing and flowing according to carefully orchestrated cycles.

13 May 2025

Researchers uncover how Entamoeba histolytica evades the immune system

The single-celled parasite Entamoeba histolytica infects 50 million people each year, killing nearly 70,000. Usually, this wily, shape-shifting amoeba causes nothing worse than diarrhea.

12 May 2025

Uncovering the architecture of the human sugar sensor

Our attraction to sugar has grown to an unhealthy level. The average person in the United States now consumes more than 100 pounds of the sweet stuff every year, up from 18 pounds in 1800.

7 May 2025

Synthetic tau protein reveals key insights into protein misfolding and fibril formation

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion.

29 Apr 2025

PET scans reveal early signs of Parkinson’s and Lewy body disorders

In a comprehensive Genomic Press perspective article published today, researchers from Fudan University and Shanghai University of Traditional Chinese Medicine have highlighted remarkable advances in the development of positron emission tomography (PET) tracers capable of visualizing α-synuclein aggregates in the brains of patients with Parkinson's disease and related disorders.

29 Apr 2025