Histology & Microscopy

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DeepInMiniscope enables high-resolution 3D imaging of brain activity in mice

Researchers at the University of California, Davis, have created a miniaturized microscope for real-time, high-resolution, non-invasive imaging of brain activity in mice.

13 Sep 2025

Rice University team develops tool to track protein aggregation hot spots

A novel strategy developed at Rice University allows scientists to zoom in on tiny segments of proteins inside living cells, revealing localized environmental changes that could indicate the earliest stages of diseases such as Alzheimer's, Parkinson's and cancer.

13 Sep 2025

Visualizing lipid transport inside living cells with fluorescence microscopy

Lipid molecules, or fats, are crucial to all forms of life. Cells need lipids to build membranes, separate and organize biochemical reactions, store energy, and transmit information.

29 Aug 2025

Groundbreaking method captures microbial memory at the earliest stages of colony growth

Bacteria aren't just mindless microbes. New research from the Hebrew University of Jerusalem reveals that single bacterial cells can carry a "memory" of their past environments-passing it down through generations-before eventually forgetting.

26 Aug 2025

Innovative cryo-microscopy offers precise views of rapid cell activity

Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, has long been a formidable task.

25 Aug 2025

New microfluidics-based workflow enables high-resolution lipid imaging in C. elegans

Understanding how fat molecules are distributed and function in living organisms is key to uncovering mechanisms of aging, disease, and metabolism.

22 Aug 2025

AI and advanced microscopy reveal tangled DNA structures with nanometer precision

At school, it's often presented as a tidy double helix but scientists are revealing the varied and intricate shapes of DNA molecules.

22 Aug 2025

PathoPlex technology maps protein patterns across human organs

Each organ in the human body contains different types of cells arranged in specific ways.

19 Aug 2025

Researchers capture first 3D real-time images of human embryo implantation

Researchers at the Institute for Bioengineering of Catalonia (IBEC) in collaboration with the Dexeus University Hospital have captured unparalleled images of a human embryo implanting.

18 Aug 2025

High-speed 3D imaging microscope captures whole organism dynamics in real time

Researchers have developed a high-speed 3D imaging microscope that can capture detailed cell dynamics of an entire small whole organism at once.

14 Aug 2025

Powerful optical technique can analyze the biochemical fingerprints of vaginal fluid

Vaginal health is tightly linked to the balance of bacteria in the microbiome, especially certain species of Lactobacillus.

12 Aug 2025

New imaging technique reveals how antibodies reshape cancer cell receptors

A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.

11 Aug 2025

Australian researchers uncover new target for next-generation malaria vaccines

Australian researchers have visualized a key protein complex in malaria parasites for the first time, uncovering a new target for next-generation vaccines that could help stop the disease from spreading.

6 Aug 2025

Study offers a promising new approach to stabilizing biomolecules

A new study from researchers at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) reveals that extremely simple peptides can mimic a biological process that protects sensitive proteins from environmental stress.

5 Aug 2025

LptM protein revealed as essential to outer membrane stability in bacteria

Gram-negative bacteria pose a significant threat to global health due to their high resistance to antibiotics compared to that of Gram-positive bacteria.

4 Aug 2025

Bacteria use amyloids as molecular armor against predators

Amyloids are perhaps best known as a key driver of Alzheimer's disease.

30 Jul 2025

High-resolution whole-cortex imaging reveals neurovascular dynamics in awake mice

Neurovascular coupling (NVC) is the dynamic regulation of cerebral blood flow in response to neural activity. Specifically, when neurons become active, nearby blood vessels dilate to increase blood supply, thereby meeting the heightened energy demands associated with neural activity.

24 Jul 2025

AI-driven microscopy predicts and tracks protein aggregation in real time

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's.

24 Jul 2025

New insights reveal how FtsZ and ZapA cooperate during bacterial cell division

Bacterial cell division, a process wherein a single cell divides to form two identical daughter cells, represents one of the most essential biological processes.

22 Jul 2025

New imaging technique reveals how cells organize glucose processing

In a scientific first, researchers from Vanderbilt University and the University of California, San Diego, have generated a high-resolution metabolic "map" of how cells orchestrate glucose processing, revealing a hidden world where organelles and molecular complexes collaborate when responding to a rush of nutrients.

22 Jul 2025