Histology & Microscopy

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Researchers identify a previously unknown cellular mechanism crucial to coronavirus replication

The discovery could serve as a starting point for antiviral strategies. A research team at Ruhr University Bochum, Germany, has identified a previously unknown cellular mechanism crucial to the replication of coronaviruses: c-Jun N-terminal kinase (JNK) is activated during infection with human coronavirus HCoV-229E and mediates the phosphorylation of the viral nucleocapsid (N) protein, an integral step in the virus cycle.

7 Nov 2025

New AI-assisted atlas can help visualize the human brain in unprecedented detail

A new AI-assisted brain atlas that can help visualize the human brain in unprecedented detail has been developed by UCL researchers, in a major step forward for neuroscience and neuroimaging.

5 Nov 2025

Opioid receptors caught in motion offering clues for safer painkillers

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid (pronounced "mew-opioid") receptors. What they didn't know - until now - was exactly what happens next.

5 Nov 2025

Breakthrough study reveals how rabies virus uses few proteins to hijack cells

New antivirals and vaccines could follow the discovery by Australian researchers of strategies used by viruses to control our cells.

5 Nov 2025

Researchers identify new molecular switch involved in programmed cell death

In the fight against disease, programmed cell death – also known as apoptosis – is a key protective function of the body. It breaks down cells that are damaged or have undergone dangerous changes.

3 Nov 2025

Scientists capture a near-continuous molecular movie of ribosome formation

Ribosomes are the cell's protein factories, which read the genetic code and assemble the proteins that every organism needs to live. But as far as how ribosomes themselves were formed, tantalizingly little was known.

30 Oct 2025

Unlocking the secrets of NMDA receptors for better brain health

As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores that let charged ions enter a cell-and the molecular gatekeepers that help control them.

29 Oct 2025

New study reveals how the glucocorticoid receptor forms complex structures inside cells

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR).

27 Oct 2025

New insight into TRPM3 heat sensor reveals how the body detects temperature

The ability to sense heat protects the body from burns and injury. But how the body actually feels temperature has remained an elusive mystery.

24 Oct 2025

Unveiling the dual role of HIV integrase in viral replication

The rate of HIV infection continues to climb globally. Around 40 million people live with HIV-1, the most common HIV strain.

24 Oct 2025

Revolutionary structures show how chaperone proteins prevent diseases caused by protein misfolding

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's Research Hospital.

15 Oct 2025

Acoustofluidic technology enables rapid detection of small extracellular vesicles

Recent research has achieved significant advances in acoustofluidic technologies for efficient isolation and biomarker-specific detection of small extracellular vesicles (sEVs).

10 Oct 2025

New insights into malaria proteins offer pathway to blocking parasite transmission

Using millions of microscope images magnified up to 130,000 times, researchers from Radboud university medical center and Toronto have unraveled the structure of two key proteins in the malaria parasite.

10 Oct 2025

Live retinal imaging uncovers early signs of diabetic eye disease

A new method of taking microscopic images of a live mouse's retina through the eye allows to record the reaction of brain cells to disease and treatment.

6 Oct 2025

New NMR technique reveals atomic-scale motion in catalytic enzyme function

Researchers from Tokyo Metropolitan University have developed a new structure determination method using Nuclear Magnetic Resonance (NMR) spectroscopy which shows how different parts of complex molecular machinery like enzymes move while they help catalyze reactions.

6 Oct 2025

Thermo Fisher Scientific expands neurodegeneration research capabilities with launch of Olink® Target 48 Neurodegeneration panel

Thermo Fisher Scientific Inc., the world leader in serving science, today announced the launch of the Olink® Target 48 Neurodegeneration panel, a high-performance, targeted proteomics immunoassay panel developed to accelerate discoveries in neurodegenerative disease research.

From Olink®- Part of Thermo Fisher Scientific 3 Oct 2025

Scientists directly visualize protein clusters linked to Parkinson’s for the first time

Scientists have, for the first time, directly visualized and quantified the protein clusters believed to trigger Parkinson's, marking a major advance in the study of the world's fastest-growing neurological disease.

2 Oct 2025

Scientists map step-by-step activation of brain receptors

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, know that even slight changes in their activity level can mean the difference between normal function and serious neurological disorders.

24 Sep 2025

New imaging technique enhances live-cell visualization in standard lab setups

Optical diffraction tomography (ODT) has long been recognized for its potential in non-invasive, label-free imaging of live biological cells. However, a major challenge arises when ODT is applied to standard multi-well cell culture plates, a common tool use under realistic laboratory conditions for biological studies.

16 Sep 2025

DeepInMiniscope enables high-resolution 3D imaging of brain activity in mice

Researchers at the University of California, Davis, have created a miniaturized microscope for real-time, high-resolution, non-invasive imaging of brain activity in mice.

13 Sep 2025

Histology & Microscopy

Researchers identify a previously unknown cellular mechanism crucial to coronavirus replication

New AI-assisted atlas can help visualize the human brain in unprecedented detail

Opioid receptors caught in motion offering clues for safer painkillers

Breakthrough study reveals how rabies virus uses few proteins to hijack cells

Researchers identify new molecular switch involved in programmed cell death

Scientists capture a near-continuous molecular movie of ribosome formation

Unlocking the secrets of NMDA receptors for better brain health

New study reveals how the glucocorticoid receptor forms complex structures inside cells

New insight into TRPM3 heat sensor reveals how the body detects temperature

Unveiling the dual role of HIV integrase in viral replication

Revolutionary structures show how chaperone proteins prevent diseases caused by protein misfolding

Acoustofluidic technology enables rapid detection of small extracellular vesicles

New insights into malaria proteins offer pathway to blocking parasite transmission

Live retinal imaging uncovers early signs of diabetic eye disease

New NMR technique reveals atomic-scale motion in catalytic enzyme function

Thermo Fisher Scientific expands neurodegeneration research capabilities with launch of Olink® Target 48 Neurodegeneration panel

Scientists directly visualize protein clusters linked to Parkinson’s for the first time

Scientists map step-by-step activation of brain receptors

New imaging technique enhances live-cell visualization in standard lab setups

DeepInMiniscope enables high-resolution 3D imaging of brain activity in mice

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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