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Safety, reactogenicity, and immunogenicity of the BNT and half-m1273 mRNA COVID-19 vaccines given as a fourth dose booster

Researchers evaluated the immunogenicity of Pfizer’s BNT162b2 and Moderna’s mRNA-1273 vaccines offered as the fourth dose against SARS-CoV-2.

12 Apr 2022

Differences in symptoms and risk of hospitalization following infection with Omicron or Delta SARS-CoV-2 variants among vaccinated people

A recent study assessed the prevalence of SARS-CoV-2 symptoms and the risk of hospitalization in vaccinated individuals infected with SARS-CoV-2 Omicron and Delta variants.

12 Apr 2022

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Researchers identified mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoproteins (NP) epitope flanking regions and their potential effects on CD8+ T cell activation.

12 Apr 2022

Unique heightened aggregation of SARS-CoV-2 Delta variant spike pseudotyped particles

A recent study illustrated the enhanced distinct clustering of pseudotyped particles (PPs) expressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant.

12 Apr 2022

NVX-CoV2373 vaccine found to induce functional SARS-CoV-2-specific T cell responses

In a recent study researchers evaluated the T cell responses elicited by full-length severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein vaccine NVX-CoV2373.

12 Apr 2022

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

A recent article posted to the bioRxiv* preprint server illustrated that the activation of the Hippo signaling pathway upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection aids the host antiviral response.

11 Apr 2022

Therapies for LGL leukemia should target the immune system, not only cancer cells

An international study coordinated by a University of Helsinki research group demonstrates that the body's immune system attacks itself in a rare type of blood cancer.

11 Apr 2022

Inflammation weakens odor signals and may be responsible for COVID19 loss of smell

Anosmia, the loss of smell, is a frequent and often long-term symptom associated with COVID-19 that can severely burden a person's quality of life, making it extremely difficult to taste foods, detect airborne hazards in the environment and carry out other functions dependent on the sense.

11 Apr 2022

Study identifies several therapeutically effective drugs for bladder cancer

Hundreds of chemical compounds were screened on cell cultures representing different stages and subtypes of bladder cancer and several promising agents with inhibitory (growth-inhibiting) effects were identified.

11 Apr 2022

Cryo-electron microscopy shows how Omicron BA.2 structure differs from BA.1 substantially

Researchers used cryogenic electron microscopy (cryo-EM) to determine the structure of the spike (S) protein of BA.2 sub-variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) and compared them with previously determined S structures of Omicron's BA.1 sub-variant.

11 Apr 2022

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers - ATR inhibitor elimusertib and PARP inhibitor AZD5305 - are safe and clinically beneficial in treating patients with advanced solid tumors.

11 Apr 2022

Patients with allergic disorders have greater risk of high blood pressure and coronary heart disease

Data from the National Health Interview Survey demonstrated adults with a history of allergic disorders have an increased risk of high blood pressure and coronary heart disease, with the highest risk seen in Black male adults.

11 Apr 2022

The relationship between household type, COVID-19 and mental health

Researchers demonstrated the relationship between the built environment with a common element and coronavirus disease 2019 (COVID-19) transmission and mental health conditions.

11 Apr 2022

Study finds molecular features responsible for the development of metastatic breast cancer

Susana Garcia-Recio, PhD, a research associate in the lab of Charles M. Perou, PhD, at UNC Lineberger Comprehensive Cancer Center, will present findings that identified molecular features responsible for the development and progression of metastatic breast cancer at the 2022 American Association for Cancer Research annual meeting. (Presentation: Abstract LB176/4, Tuesday, April 12, 3:20 p.m. ET, Room 217-219, Ernest N. Morial Convention Center in New Orleans.)

11 Apr 2022

Discovery of key regulator of body weight could lead to new treatments for metabolic disorders

Yale scientists uncover key regulator of body weight. Yale scientists have discovered that a protein known as augmentor-alpha regulates body weight in mice, an insight that could lead to new treatments for metabolic disorders.

11 Apr 2022

Evidence of an increased risk of neurodegeneration after SARS-CoV-2 infection

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11 Apr 2022

COVID-19 increases risk of bleeding, DVT, and pulmonary embolism

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11 Apr 2022

Study finds higher risk of all-cause mortality among pediatric cancer patients in LMICs during the pandemic

During the first nine months of the COVID-19 pandemic, pediatric cancer patients from lower- and middle-income countries faced a higher risk of all-cause mortality than those in high-income countries, according to data presented at the AACR Annual Meeting 2022, held April 8-13.

11 Apr 2022

Safety of COVID booster doses and obstetric outcomes in pregnancy

Researchers determine whether there is any risk posed to pregnant women who have received a booster vaccine dose during pregnancy.

11 Apr 2022

Tobacco use increased in smokers trying to quit during COVID-19, study finds

While smoking rates have declined dramatically in the United States, there are still 35 million smokers. There are few data about whether, and if so, how current cigarette smoking habits among those trying to quit are affected by the COVID-19 pandemic.

11 Apr 2022

Medical Research News

Safety, reactogenicity, and immunogenicity of the BNT and half-m1273 mRNA COVID-19 vaccines given as a fourth dose booster

Differences in symptoms and risk of hospitalization following infection with Omicron or Delta SARS-CoV-2 variants among vaccinated people

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Unique heightened aggregation of SARS-CoV-2 Delta variant spike pseudotyped particles

NVX-CoV2373 vaccine found to induce functional SARS-CoV-2-specific T cell responses

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

Therapies for LGL leukemia should target the immune system, not only cancer cells

Inflammation weakens odor signals and may be responsible for COVID19 loss of smell

Study identifies several therapeutically effective drugs for bladder cancer

Cryo-electron microscopy shows how Omicron BA.2 structure differs from BA.1 substantially

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Patients with allergic disorders have greater risk of high blood pressure and coronary heart disease

The relationship between household type, COVID-19 and mental health

Study finds molecular features responsible for the development of metastatic breast cancer

Discovery of key regulator of body weight could lead to new treatments for metabolic disorders

Evidence of an increased risk of neurodegeneration after SARS-CoV-2 infection

COVID-19 increases risk of bleeding, DVT, and pulmonary embolism

Study finds higher risk of all-cause mortality among pediatric cancer patients in LMICs during the pandemic

Safety of COVID booster doses and obstetric outcomes in pregnancy

Tobacco use increased in smokers trying to quit during COVID-19, study finds

Membrane proteins in focus: Turning high-risk targets into routine workflows

How metabolic phenotyping can detect viral infections in minutes

Directed enzyme evolution and the Nobel Prize: Making enzymes evolve in the lab

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