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Patients with severe COVID-19 may have lower oxygen requirements than previously believed

A new study, led by researchers at Uppsala University, shows that all individual patients suffering from severe COVID-19 may have lower oxygen requirements than was formerly believed. The study was conducted at a Swedish district hospital during the first wave of the pandemic in 2020.

1 Feb 2022

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Exogenous trypsin treatment boosts SARS-CoV-2 infection in Vero E6 cells and promotes viral multiplication in cultured cells.

1 Feb 2022

Weight loss by overweight and obese people associated with reduced risk of colorectal adenoma

A new paper in JNCI Cancer Spectrum, published by Oxford University Press, indicates that overweight and obese people who lose weight may reduce their chances of later developing colorectal adenoma – a type of benign growth or polyp in the colon or rectum that could lead to colorectal cancer.

1 Feb 2022

Study reveals seven major determinants of mortality risk for patients with COVD-19 and thoracic cancer

The risk of death for patients with SARS-CoV-2 infection and thoracic cancer is based on seven major determinants, according to research published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer.

1 Feb 2022

Study finds that high-dose convalescent plasma does not improve outcomes for severe COVID-19

A randomized controlled trial assesses the efficacy and safety of high-dose convalescent plasma in the treatment of severe COVID-19.

1 Feb 2022

High levels of neutralizing antibodies against Omicron after BNT162b2 booster vaccination

Researchers analyze the neutralizing antibody levels against SARS-CoV-2 VOCs in individuals after receiving their second and third doses.

1 Feb 2022

TTUHSC project awarded new NIH grant to advance research on amygdala pain mechanisms

It is estimated that more than 100 million U.S. adults are affected by chronic pain, a condition that annually costs the country an estimated $560-635 billion in health care costs, disability and lost productivity.

1 Feb 2022

Families of Black patients found to have greater risk for dilated cardiomyopathy

Black patients diagnosed with dilated cardiomyopathy (DCM) of unknown cause are more likely to have family members at risk of developing the heart muscle disease than families of white patients, according to results of a multi-site study led by researchers at The Ohio State University Wexner Medical Center and College of Medicine.

1 Feb 2022

Neighborhood socioeconomic status associated with poorer patient outcomes after heart surgery

Patients with mitral valve disease who live in disadvantaged communities are more likely to experience complications and are at higher risk for death after surgery than those with higher socioeconomic status (SES), according to research presented at the 58th Annual Meeting of The Society of Thoracic Surgeons.

1 Feb 2022

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

Neural stem cells (NSCs) engineered by Northwestern Medicine investigators used in combination with the HER2 inhibitor drug tucatinib improved survival in mice with HER2-positive breast cancer brain metastases, according to findings published in Proceedings of the National Academy of Sciences.

1 Feb 2022

Scientists discover new insights about lymphangioleiomyomatosis

Researchers have discovered new insights about lymphangioleiomyomatosis (LAM), a rare lung disease, which affects about 1 in 200,00 Americans and commonly features the growth of abnormal cells in different tissues and organs, including the lungs.

1 Feb 2022

Zika virus vaccine candidate found to be safe and effective in preclinical animal studies

A Zika virus vaccine candidate is effective at preventing the Zika virus passing from mother to fetus in preclinical animal studies, according to a new study in the journal npj Vaccines.

1 Feb 2022

Mutational analysis of SARS-CoV-2 main protease

A new study discussed the findings of a comprehensive mutational analysis of the main protease (Mpro) of SARS-CoV-2.

1 Feb 2022

Assessing the effects of booster vaccinations against SARS-CoV-2 Omicron variant

In a new study, researchers analyzed the effect of vaccine booster doses against the SARS-CoV-2 Omicron variant.

1 Feb 2022

Daily physical activity boosts cognitive performance in middle-aged and older adults

A new study by researchers at University of California San Diego School of Medicine adds to the canon of research associating physical activity with cognitive performance, this time using 90 middle-aged and older subjects who wore accelerometers while physically active and completed mobile cognitive testing from home.

1 Feb 2022

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

In a new study, a team of researchers assessed the neutralizing activity of XAV-19, a glyco-humanized polyclonal antibody derived from hyperimmunized animal hosts, against the SARS-CoV-2 Omicron variant.

1 Feb 2022

Impact of using AI to generate primers for detection of SARS-CoV-2 Omicron variant

In a new study, researchers designed artificial intelligence (AI)-based primers for the SARS-CoV-2 Omicron variant.

1 Feb 2022

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

In a new study, a team of researchers used co-immunoprecipitation and in vitro interaction assays to identify the molecular basis of interaction of SARS-CoV-2 non-structural protein 2 with eIF4E-homologous protein (4EHP)-GRB10-interacting glycine-tyrosine-phenylalanine domain protein 2 complex, involved in microRNA-mediated gene silencing in human cells.

1 Feb 2022

Illustrating the structural diversity of SARS-CoV-2 Omicron spike

In a new study, a team of researchers used cryo-electron microscopy to determine the spike (S) structures of the SARS-CoV-2 Omicron variant to understand how the mutations that alter its primary sequence impact S conformation.

1 Feb 2022

Researchers explore natural SARS-CoV-2 infection in pet rabbits in France

In a new study, researchers reported the first evidence of natural SARS-CoV-2 infections among domestic rabbits in France.

1 Feb 2022

Medical Research News

Patients with severe COVID-19 may have lower oxygen requirements than previously believed

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Weight loss by overweight and obese people associated with reduced risk of colorectal adenoma

Study reveals seven major determinants of mortality risk for patients with COVD-19 and thoracic cancer

Study finds that high-dose convalescent plasma does not improve outcomes for severe COVID-19

High levels of neutralizing antibodies against Omicron after BNT162b2 booster vaccination

TTUHSC project awarded new NIH grant to advance research on amygdala pain mechanisms

Families of Black patients found to have greater risk for dilated cardiomyopathy

Neighborhood socioeconomic status associated with poorer patient outcomes after heart surgery

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

Scientists discover new insights about lymphangioleiomyomatosis

Zika virus vaccine candidate found to be safe and effective in preclinical animal studies

Mutational analysis of SARS-CoV-2 main protease

Assessing the effects of booster vaccinations against SARS-CoV-2 Omicron variant

Daily physical activity boosts cognitive performance in middle-aged and older adults

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

Impact of using AI to generate primers for detection of SARS-CoV-2 Omicron variant

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

Illustrating the structural diversity of SARS-CoV-2 Omicron spike

Researchers explore natural SARS-CoV-2 infection in pet rabbits in France

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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