Gene News and Research

Latest Gene News and Research

African American youths who experienced discrimination during adolescence may develop chronic diseases

African American youth who report experiencing frequent discrimination during adolescence are at risk for developing heart disease, high blood pressure, diabetes, and stroke in later years, according to a new study.

3 Feb 2014

Ronald G. Crystal wins Pioneer Award from Human Gene Therapy

In recognition of his seminal work on adenoviral vectors, which accelerated the translation of gene therapy from the research laboratory to the clinic, Ronald G. Crystal, MD (Weill Cornell Medical College, Cornell University, New York City), has received a Pioneer Award from Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

31 Jan 2014

Treating peanut allergy with oral immunotherapy changes DNA of immune cells

Treating a peanut allergy with oral immunotherapy changes the DNA of the patient's immune cells, according to a new study from the Stanford University School of Medicine and Lucile Packard Children's Hospital Stanford. The DNA change could serve as the basis for a simple blood test to monitor the long-term effectiveness of the allergy therapy.

31 Jan 2014

Dormant prostate cancer cells in bone tissue can be reawakened, say researchers

Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute discovered in pre-clinical models that dormant prostate cancer cells found in bone tissue can be reawakened, causing metastasis to other parts of the body. Understanding this mechanism of action may allow researchers to intervene prior to disease progression.

31 Jan 2014

Study describes new tack in treatment of lung adenocarcinomas

The most common genetic subtype of lung cancer, which has long defied treatment with targeted therapies, has had its growth halted by a combination of two already-in-use drugs in laboratory and animal studies, setting the stage for clinical trials of the drugs in patients, researchers at Dana-Farber Cancer Institute and other scientists report in a new study.

31 Jan 2014

Drugs that modify DNA structure may be beneficial for treating Alzheimer's disease

In a study published this week in Nature Neuroscience, Bess Frost, PhD, and co-authors, identify abnormal expression of genes, resulting from DNA relaxation, that can be detected in the brain and blood of Alzheimer's patients.

31 Jan 2014

Sub-optimal sleep may activate depressive genes, increase risk for major depression

A genetic study of adult twins and a community-based study of adolescents both report novel links between sleep duration and depression. The studies are published in the Feb. 1 issue of the journal Sleep.

31 Jan 2014

RNAi-based screening offers MPM treatment hope

Research using RNA interference-based screening has identified several potential targets for the treatment of malignant pleural mesothelioma.

31 Jan 2014

Researchers identify potential genes that can be targeted for new treatments for hepatocellular cancer

Patients with advanced hepatocellular (or liver) cancer have high mortality rates, with existing drugs demonstrating only a small, but significant survival advantage. By combining a zebrafish model of liver cancer with data from human tumors, researchers from the Icahn School of Medicine at Mount Sinai hope to identify potential genes of interest that can be targeted for new treatments for hepatocellular carcinoma, the most common form of liver cancer to develop from liver cells.

31 Jan 2014

Researchers study how epigenetic alterations contribute to age-related increases in breast cancer risk

Age is a key risk factor for breast cancer. A recent study by researchers from the Dartmouth-Hitchcock Norris Cotton Cancer Center, "Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation," examines the connection between cancer and the aging process to see if epigenetic DNA alterations might contribute to age-related increases in breast cancer risk.

31 Jan 2014

TSRI scientists awarded grant to develop new therapeutic approaches for lung cancer

Scientists from the Florida campus of The Scripps Research Institute have been awarded approximately $1.8 million from the National Cancer Institute of the National Institutes of Health to identify the signaling pathways that underlie lung cancer and to use this information to develop new therapeutic approaches.

30 Jan 2014

Neuroscientist, researchers receive Vilcek Prize in Biomedical Science

The Vilcek Foundation is pleased to name Thomas M. Jessell as the winner of the 2014 Vilcek Prize in Biomedical Science. Awarded annually, the Vilcek Prizes honor the contributions of immigrants to the American arts and sciences, and include $100,000 cash awards.

30 Jan 2014

CTI announces initiation of pacritinib Phase 2 trial in AML patients with FLT3 mutations

Cell Therapeutics, Inc. today announced the initiation of an international cooperative group Phase 2 clinical trial of pacritinib in adult patients with relapsed acute myeloid leukemia (AML) with mutations of the FLT3 gene. Mutation of the FLT3 gene is found in approximately one-third of AML patients and is an independent risk factor for poor prognosis.

30 Jan 2014

TCGA Research Network identify new potential therapeutic targets for major form of bladder cancer

Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified new potential therapeutic targets for a major form of bladder cancer, including important genes and pathways that are disrupted in the disease.

30 Jan 2014

Findings on molecular defects behind bladder cancer may pave way for new, targeted treatments

The once sketchy landscape of the molecular defects behind bladder cancer now resembles a road map to new, targeted treatments thanks to the unified efforts of scientists and physicians at 40 institutions.

30 Jan 2014

New insight into mammalian circadian rhythms could lead to therapies for metabolic disorders

We've all heard about circadian rhythm, the roughly 24-hour oscillations of biological processes that occur in many living organisms. Yet for all its influence in many aspects of our lives - from sleep to immunity and, particularly, metabolism - relatively little is understood about the mammalian circadian rhythm and the interlocking processes that comprise this complex biological clock.

30 Jan 2014

Bladder, lung cancers are marked by shared differences in genetics that control cell cycle

A University of Colorado Cancer Center study published in the journal PLoS ONE shows that bladder and lung cancers are marked by shared differences in the genetics that control the cell cycle.

30 Jan 2014

Vaccine to treat precancerous cervical lesions triggers immune cell response

Preliminary results of a small clinical trial show that a vaccine used to treat women with high-grade precancerous cervical lesions triggers an immune cell response within the damaged tissue itself.

30 Jan 2014

Dormant prostate cancer cells within bone tissue can be reawakened to a cancerous state

Dormant prostate cancer cells in bone tissue can be reawakened to cause secondary tumours, according to new research published in Endocrine-Related Cancer. Targeting the wake-up call could prevent metastasis and improve prostate cancer survival rates.

29 Jan 2014

Myriad Genetics' Prolaris opens door to a new era of personalized treatment for prostate cancer

Myriad Genetics, Inc. today announced results from PROCEDE 500, a clinical utility study with its Prolaris test, at the 2014 ASCO Genitourinary Cancers Symposium in San Francisco, Calif. The study demonstrated the significant clinical value of Prolaris to physicians who are treating men with prostate cancer. Prolaris is a prognostic test that accurately predicts prostate cancer-specific death and metastases and has been validated in 11 clinical studies with more than 5,000 patients.

29 Jan 2014

Gene News and Research

Latest Gene News and Research

African American youths who experienced discrimination during adolescence may develop chronic diseases

Ronald G. Crystal wins Pioneer Award from Human Gene Therapy

Treating peanut allergy with oral immunotherapy changes DNA of immune cells

Dormant prostate cancer cells in bone tissue can be reawakened, say researchers

Study describes new tack in treatment of lung adenocarcinomas

Drugs that modify DNA structure may be beneficial for treating Alzheimer's disease

Sub-optimal sleep may activate depressive genes, increase risk for major depression

RNAi-based screening offers MPM treatment hope

Researchers identify potential genes that can be targeted for new treatments for hepatocellular cancer

Researchers study how epigenetic alterations contribute to age-related increases in breast cancer risk

TSRI scientists awarded grant to develop new therapeutic approaches for lung cancer

Neuroscientist, researchers receive Vilcek Prize in Biomedical Science

CTI announces initiation of pacritinib Phase 2 trial in AML patients with FLT3 mutations

TCGA Research Network identify new potential therapeutic targets for major form of bladder cancer

Findings on molecular defects behind bladder cancer may pave way for new, targeted treatments

New insight into mammalian circadian rhythms could lead to therapies for metabolic disorders

Bladder, lung cancers are marked by shared differences in genetics that control cell cycle

Vaccine to treat precancerous cervical lesions triggers immune cell response

Dormant prostate cancer cells within bone tissue can be reawakened to a cancerous state

Myriad Genetics' Prolaris opens door to a new era of personalized treatment for prostate cancer

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