Gene News and Research

Latest Gene News and Research

Study finds how to shut down Bcl6 in diffuse large B-cell lymphoma

The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex to target with a drug since it is also crucial to the healthy functioning of many immune cells in the body, not just B cells gone bad.

4 Mar 2013

Study identifies how new ALS gene mutations cause other diseases of the brain, muscle and bone

Researchers supported by The ALS Association have discovered how mutations in new amyotrophic lateral sclerosis (ALS) genes cause not only ALS but also other diseases of the brain, muscle and bone.

4 Mar 2013

Investigators identify seven new genetic regions associated with AMD

An international group of investigators has identified seven new genetic regions associated with age-related macular degeneration (AMD), a common cause of blindness in older individuals. The findings, reported online March 3 in Nature Genetics, could point to new biological pathways and therapeutic targets for AMD.

4 Mar 2013

Researchers discover how LRRK2 mutations in familial Parkinson's damage brain cells

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered how the most common genetic mutations in familial Parkinson's disease damage brain cells.

4 Mar 2013

Study identifies two gene mutations that lead to death of nerve cells in ALS

A study led by St. Jude Children's Research Hospital has discovered mutations in two genes that lead to the death of nerve cells in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and related degenerative diseases.

4 Mar 2013

Knockdown or deletion of Jmjd3 gene could improve efficiency of stem cell conversion process

The removal of a genetic roadblock could improve the efficiency of converting adult cells into stem cells by 10 to 30 times, report scientists from The Methodist Hospital Research Institute and two other institutions in the latest issue of Cell.

3 Mar 2013

UNC1215 chemical probe can help investigate L3MBTL3 methyl-lysine reader domain

In an article published as the cover story of the March 2013 issue of Nature Chemical Biology, Lindsey James, PhD, research assistant professor in the lab of Stephen Frye, Fred Eshelman Distinguished Professor in the UNC School of Pharmacy and member of the UNC Lineberger Comprehensive Cancer Center, announced the discovery of a chemical probe that can be used to investigate the L3MBTL3 methyl-lysine reader domain.

3 Mar 2013

Researchers identify mechanisms that connect variety of diseases linked with inflammation

A study led by researchers at Boston University School of Medicine (BUSM) has identified epigenetic mechanisms that connect a variety of diseases associated with inflammation.

3 Mar 2013

Significant link between defective viruses and increased rate of transmission of major disease

Defective viruses, thought for decades to be essentially garbage unrelated to the transmission of normal viruses, now appear able to play an important role in the spread of disease, new research by UCLA life scientists indicates.

2 Mar 2013

Oxford researcher wins 2013 John Dystel Prize from AAN, National Multiple Sclerosis Society

The American Academy of Neurology and the National Multiple Sclerosis Society are awarding the 2013 John Dystel Prize for MS Research to George C. Ebers, MD, a leading researcher with the University of Oxford and Oxford University Hospitals Trust in Oxford, United Kingdom.

2 Mar 2013

Scientists discover enzyme regulation that catalyzes chain elongation in the terpenoid pathway

Max Planck scientists in Jena, Germany, have discovered an unusual regulation of enzymes that catalyze chain elongation in an important secondary metabolism, the terpenoid pathway.

2 Mar 2013

Nationwide clinical drug trials give hope for patients with autism and fragile X syndrome

As scientists uncover the precise links between autism and the fragile x gene, potential treatments to reverse many of the core symptoms of both autism and fragile X syndrome (FXS) are moving closer to reality.

2 Mar 2013

Researchers identify novel signaling pathway responsible for neuroprotective activity of parkin

Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich identify a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death.

2 Mar 2013

Synthetic progesterone birth control injections have vulnerability to certain infections: Research

Women who are pregnant or using synthetic progesterone birth control injections have a conspicuous vulnerability to certain infections including malaria, Listeria, HIV, and herpes simplex virus.

2 Mar 2013

Kallikrein gene variants modulate OSCC development

Polymorphisms in the kallikrein7 and kallikrein10 genes are associated with the development and progression of oral squamous cell carcinoma, a study in Taiwanese men indicates.

1 Mar 2013

Researchers elucidate how Fgf8 is controlled by multiple regulatory elements in mammal embryos

During embryo development, genes are dynamically, and very precisely, switched on and off to confer different properties to different cells and build a well-proportioned and healthy animal. Fgf8 is one of the key genes in this process, controlling in particular the growth of the limbs and the formation of the different regions of the brain. Researchers at EMBL have elucidated how Fgf8 in mammal embryos is, itself, controlled by a series of multiple, interdependent regulatory elements.

1 Mar 2013

Pivotal study of olesoxime in Spinal Muscular Atrophy receives positive interim review

Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics from discovery to clinical validation for under-served medical needs in neurology and cardiology, announced the completion of the interim analysis of the pivotal efficacy study of olesoxime in the rare neurodegenerative condition Spinal Muscular Atrophy (SMA).

1 Mar 2013

New way to identify heterogeneous brain cells by looking at epigenetic variation

Scientists from the Johns Hopkins University School of Medicine in Baltimore, MD have developed a new way to identify heterogeneous brain cells by looking at epigenetic variation (the heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence).

1 Mar 2013

Researchers develop new genetically altered mice that model earliest stages of Alzheimer's

Researchers at the University of Florida and The Johns Hopkins University have developed a line of genetically altered mice that model the earliest stages of Alzheimer's disease. This model may help scientists identify new therapies to provide relief to patients who are beginning to experience symptoms.

1 Mar 2013

UPV/EHU team uses lipid nanoparticles to develop new formulations for drug delivery

At the Faculty of Pharmacy of the Basque Public University (UPV/EHU) the Pharmacokinetics, Nanotechnology and Gene Therapy research team is using nanotechnology to develop new formulations that can be applied to drugs and gene therapy.

1 Mar 2013

Gene News and Research

Latest Gene News and Research

Study finds how to shut down Bcl6 in diffuse large B-cell lymphoma

Study identifies how new ALS gene mutations cause other diseases of the brain, muscle and bone

Investigators identify seven new genetic regions associated with AMD

Researchers discover how LRRK2 mutations in familial Parkinson's damage brain cells

Study identifies two gene mutations that lead to death of nerve cells in ALS

Knockdown or deletion of Jmjd3 gene could improve efficiency of stem cell conversion process

UNC1215 chemical probe can help investigate L3MBTL3 methyl-lysine reader domain

Researchers identify mechanisms that connect variety of diseases linked with inflammation

Significant link between defective viruses and increased rate of transmission of major disease

Oxford researcher wins 2013 John Dystel Prize from AAN, National Multiple Sclerosis Society

Scientists discover enzyme regulation that catalyzes chain elongation in the terpenoid pathway

Nationwide clinical drug trials give hope for patients with autism and fragile X syndrome

Researchers identify novel signaling pathway responsible for neuroprotective activity of parkin

Synthetic progesterone birth control injections have vulnerability to certain infections: Research

Kallikrein gene variants modulate OSCC development

Researchers elucidate how Fgf8 is controlled by multiple regulatory elements in mammal embryos

Pivotal study of olesoxime in Spinal Muscular Atrophy receives positive interim review

New way to identify heterogeneous brain cells by looking at epigenetic variation

Researchers develop new genetically altered mice that model earliest stages of Alzheimer's

UPV/EHU team uses lipid nanoparticles to develop new formulations for drug delivery

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