Gene News and Research

Latest Gene News and Research

SOX2 directly regulated by tumor suppressor CDKN1B(p27) gene

A team of researchers from the Spanish National Cancer Research Centre (CNIO), led by Manuel Serrano, from the Tumour Suppression Group, together with scientists from London and Santiago de Compostela, has discovered that the cellular reprogramming gene SOX2, which is involved in several types of cancers, such as lung cancer and pituitary cancer, is directly regulated by the tumor suppressor CDKN1B(p27) gene, which is also associated with these types of cancer.

6 Dec 2012

Researchers unlock mechanisms of how the body converts dietary carbohydrates into fat

A gene that helps the body convert that big plate of holiday cookies you just polished off into fat could provide a new target for potential treatments for fatty liver disease, diabetes and obesity.

6 Dec 2012

‘Weekend pill’ employed for muscular dystrophy

A drug used to treat erectile dysfunction may prevent functional muscle ischemia in patients with Becker muscular dystrophy, a small randomized trial shows.

6 Dec 2012

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the memories and livelihoods of millions-leaving patients and their families struggling to cope with the disease's devastating consequences. But today, scientists at the Gladstone Institutes propose a new research avenue that has the potential to change all that.

6 Dec 2012

Scientists evaluate two different strategies to treat Usher syndrome

After years of basic research, scientists at Johannes Gutenberg University Mainz (JGU) are increasingly able to understand the mechanisms underlying the human Usher syndrome and are coming ever closer to finding a successful treatment approach. The scientists in the Usher research group of Professor Dr. Uwe Wolfrum are evaluating two different strategies. These involve either the repair of mutated genes or the deactivation of the genetic defects using agents.

6 Dec 2012

TAU scientists win top prize in American Society of Human Genetics art competition

The fine arts and the exact sciences may appear an unlikely pair, but creativity is a crucial element in both. Prof. Karen Avraham and PhD candidate Shaked Shivatzki of Tel Aviv University's Sackler Faculty of Medicine embraced this truth when creating Hearing and Deafness: Structure and Sequence, their winning submission to the recent American Society of Human Genetics art competition.

6 Dec 2012

Ponatinib offers new hope in drug-resistant leukemia

An investigational tyrosine kinase inhibitor, ponatinib, has shown high levels of activity in patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.

5 Dec 2012

RXi commences RXI-109 Phase 1 study for management of surgical scars and keloids

RXi Pharmaceuticals Corporation, today announced that dosing with their anti-scarring drug, RXI-109, for the management of surgical and hypertrophic scars and keloids has been initiated.

5 Dec 2012

Copper can prevent horizontal transmission of genes in antibiotic-resistant bacteria

New research from the University of Southampton has shown that copper can prevent horizontal transmission of genes, which has contributed to the increasing number of antibiotic-resistant infections worldwide.

5 Dec 2012

New method can generate stable human mesenchymal stem cells for bone engineering

Human mesenchymal stem cells (hMSCs) can develop into bone cells and are useful for tissue engineering and regeneration. However, when grown in the laboratory they quickly lose their ability to continue dividing and they die.

5 Dec 2012

Inserm prizes for medical research to be awarded on Dec. 3

The 2012 Inserm prizes for medical research will be awarded at a ceremony at the Coll-ge de France on Monday 3 December 2012. This year, the grand prize will be awarded to Philippe Sansonetti in the presence of Marisol Touraine, France's Minister of Social Affairs and Health, Genevi-ve Fioraso, France's Minister of Higher Education and Research, and Professor Andr- Syrota, Chairman and CEO of Inserm.

5 Dec 2012

Highlights for December 2012 issue of GSA’s Genetics journal

Listed below are the selected highlights for the December 2012 issue of the Genetics Society of America's journal, Genetics.

5 Dec 2012

METACARDIS project to develop and implement personalized treatments for patients with CMDs

Thanks to the support of the European Commission, fourteen partners in six European countries will work together over a five-year period to translate the results obtained with novel CMD diagnosis and treatment methods and pave the way for personalised medicine in CMDs. Researchers and clinicians from the Institute of Cardiometabolism and Nutrition (ICAN) will also be involved in the METACARDIS project.

5 Dec 2012

Study: Risk for skin cancer involves numerous genetic factors

It's common knowledge that excessive UV exposure from sunlight raises your chances for skin cancer, but predicting whether someone will actually develop skin cancer remains difficult. In a new research report, scientists from the University of Alabama at Birmingham (UAB) and the University of Wisconsin-Madison show that the risk for skin cancer involves numerous genetic factors including family history, ethnicity, and genetic variations specific to each individual.

5 Dec 2012

Researchers investigate GPER receptor as possible new drug target for breast cancer

Five-year breast cancer survival rates have improved dramatically over the past 50 years, but tumors can recur up to ten or more years after they are detected. When tumors recur, they are even more difficult to treat.

5 Dec 2012

Mutations signaling poor neuroblastoma prognosis identified

Children with neuroblastoma who have mutations in the ARID1A and ARID1B genes in their tumors have a poor prognosis compared with those without these alterations, show study findings.

4 Dec 2012

Adiponectin level may underpin atherogenic haptoglobin phenotype

Researchers have suggested an active role for adiponectin in the pathophysiology of vascular disease in patients with diabetes, that depends on their haptoglobin phenotype.

4 Dec 2012

Data from OncoSec Medical clinical studies to be presented at DNA Vaccines 2012 Conference

OncoSec Medical Inc., a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumor cancers, announced it will be presenting at the DNA Vaccines 2012 Conference at the Loews Coronado Bay Resort in San Diego, California. OncoSec is a Silver Sponsor of the conference.

4 Dec 2012

Hebrew University researchers pave way for development of new approaches to cure malaria

More than a million people die each year of malaria caused by different strains of the Plasmodium parasite transmitted by the Anopheles mosquito. The medical world has yet to find an effective vaccine against the deadly parasite, which mainly affects pregnant women and children under the age of five. By figuring out how the most dangerous strain evades the watchful eye of the immune system, researchers from the Hebrew University of Jerusalem have now paved the way for the development of new approaches to cure this acute infection.

4 Dec 2012

Childhood trauma can leave permanent epigenetic marks on DNA

Abused children are at high risk of anxiety and mood disorders, as traumatic experience induces lasting changes to their gene regulation. Scientists from the Max Planck Institute of Psychiatry in Munich have now documented for the first time that genetic variants of the FKBP5 gene can influence epigenetic alterations in this gene induced by early trauma.

3 Dec 2012

Gene News and Research

Latest Gene News and Research

SOX2 directly regulated by tumor suppressor CDKN1B(p27) gene

Researchers unlock mechanisms of how the body converts dietary carbohydrates into fat

‘Weekend pill’ employed for muscular dystrophy

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Scientists evaluate two different strategies to treat Usher syndrome

TAU scientists win top prize in American Society of Human Genetics art competition

Ponatinib offers new hope in drug-resistant leukemia

RXi commences RXI-109 Phase 1 study for management of surgical scars and keloids

Copper can prevent horizontal transmission of genes in antibiotic-resistant bacteria

New method can generate stable human mesenchymal stem cells for bone engineering

Inserm prizes for medical research to be awarded on Dec. 3

Highlights for December 2012 issue of GSA’s Genetics journal

METACARDIS project to develop and implement personalized treatments for patients with CMDs

Study: Risk for skin cancer involves numerous genetic factors

Researchers investigate GPER receptor as possible new drug target for breast cancer

Mutations signaling poor neuroblastoma prognosis identified

Adiponectin level may underpin atherogenic haptoglobin phenotype

Data from OncoSec Medical clinical studies to be presented at DNA Vaccines 2012 Conference

Hebrew University researchers pave way for development of new approaches to cure malaria

Childhood trauma can leave permanent epigenetic marks on DNA

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting