Gene News and Research

Latest Gene News and Research

Scripps Florida designs new compound that shows promise against tremor ataxia syndrome

Scientists on the Florida campus of The Scripps Research Institute have designed a compound that shows promise as a potential therapy for one of the diseases closely linked to fragile X syndrome, a genetic condition that causes mental retardation, infertility, and memory impairment, and is the only known single-gene cause of autism.

6 Sep 2012

Key facts about polycystic ovary syndrome

September marks Polycystic Ovary Syndrome (PCOS) awareness month and with this condition affecting millions of women in the world, there are some key facts about the condition to highlight that can affect a women's fertility when suffering with the disorder.

6 Sep 2012

Pfizer receives FDA approval for BOSULIF to treat Ph+ chronic myelogenous leukemia

Pfizer Inc. announced today the U.S. Food and Drug Administration (FDA) has approved BOSULIF (bosutinib), an Abl and Src kinase inhibitor, for the treatment of adult patients with chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance, or intolerance to prior therapy.

6 Sep 2012

UEA, IFR to study protective effects of broccoli consumption against prostate cancer

The Prostate Cancer Foundation is providing $1M of funding to the Institute of Food Research and the University of East Anglia (UEA) to study the protective effects of broccoli consumption against prostate cancer.

6 Sep 2012

Alnylam announces complete results from ALN-RSV01 Phase IIb trial on RSV infection

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today complete results from its Phase IIb trial with ALN-RSV01 for the treatment of respiratory syncytial virus (RSV) infection in lung transplant patients.

6 Sep 2012

LIN28 protein can bind directly to thousands of messenger RNAs

A study led by researchers at the UC San Diego Stem Cell Research program and funded by the California Institute for Regenerative Medicine (CIRM) looks at an important RNA binding protein called LIN28, which is implicated in pluripotency and reprogramming as well as in cancer and other diseases.

6 Sep 2012

Researchers discover two gene variants that raise risk of pediatric cancer neuroblastoma

Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma. Using automated technology to perform genome-wide association studies on DNA from thousands of subjects, the study broadens understanding of how gene changes may make a child susceptible to this early childhood cancer, as well as causing a tumor to progress.

5 Sep 2012

Epizyme commences EPZ-5676 Phase 1 study for MLL-r leukemia

Epizyme, Inc., a company leading the creation of a new class of personalized therapeutics for patients with genetically defined cancers, announced today that it has initiated a Phase 1 Study of EPZ-5676. EPZ-5676 is a novel small molecule inhibitor of DOT1L, a histone methyltransferase (HMT) that is critical to the development of a specific type of acute leukemia defined by rearrangement of the MLL gene (MLL-r leukemia).

5 Sep 2012

More findings on genetic complexity behind type 2 diabetes

Using a new method, diabetes researchers at Lund University, Sweden, have been able to reveal more of the genetic complexity behind type 2 diabetes.

5 Sep 2012

Phase 1b trial validates efficacy of Pulmatrix PUR118 to treat COPD

Pulmatrix, Inc., a clinical stage biotechnology company creating novel inhaled therapeutics, today announced top line results from a clinical study showing that the novel inhaled therapeutic, PUR118, demonstrated anti-inflammatory efficacy and was well-tolerated in two Phase 1b studies in patients with chronic obstructive pulmonary disease (COPD).

5 Sep 2012

Fusion-negative prostate tumours display more aberrant DNA methylations

In about half of all prostate tumours, there are two genetic areas that are fused with one another. When this is not the case, the exact way cancer cells originate in prostate tumours was not clear until now.

5 Sep 2012

Baxter seeks FDA BLA approval for BAX 326 rFIX protein to treat hemophilia B

Baxter International Inc. today announced that the company has submitted a biologics license application to the United States Food and Drug Administration for approval of BAX 326, a recombinant factor IX (rFIX) protein being investigated for the treatment and prophylaxis of bleeding episodes for patients over 12 years of age with hemophilia B.

From Baxter International Inc. 5 Sep 2012

Regular Fanconi anemia cells aren't sensitive to resveratrol

Fanconi anemia is a recessive genetic disorder affecting 1 in 350,000 babies, which leaves cells unable to repair damaged DNA. This lack of repair puts Fanconi anemia patients at high risk for developing a variety of cancers, especially leukemias and head and neck cancer.

5 Sep 2012

Drugs targeting protein TGF-β may be used to treat ovarian cancer

In the September issue of the Journal of Clinical Investigation, researchers at MD Anderson Cancer Center report that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth.

5 Sep 2012

ImmusanT commences Nexvax2 clinical trials for celiac disease in New Zealand, Australia and the U.S.

ImmusanT announced today that it has initiated clinical trials in New Zealand, Australia and the U.S. to evaluate Nexvax2, the first therapeutic vaccine for patients with celiac disease. Nexvax2 is designed to re-establish patients' tolerance to the toxic effects of gluten, a protein in wheat, barley and rye, and allow them to return to a normal diet.

5 Sep 2012

Motor coordination in children with sedentary lifestyles: an interview with Dr. Luis Lopes

The importance of an adequate motor coordination level in childhood has recently reemerged. In literature on motor skill development, the focus is mostly on the proficiency/competence level in movement skills. Motor competence/coordination can be defined as a person’s ability to execute different motor acts, including coordination of both fine and gross motor skills (Henderson & Sugden, 1992).

4 Sep 2012

Biokine, BioLineRx sign license agreement to develop and commercialize BL-8040 for AML

BioLineRx Ltd., a biopharmaceutical drug development company, announced today that it has signed an exclusive, worldwide license agreement with Biokine Therapeutics Ltd., a Clal Biotechnology Industries portfolio company, for the development and commercialization of BL-8040 (formerly BKT-140), a Phase II ready drug candidate for the treatment of acute myeloid leukemia (AML), as well as other types of hematological cancer.

4 Sep 2012

Gene News and Research

Latest Gene News and Research

Scripps Florida designs new compound that shows promise against tremor ataxia syndrome

Key facts about polycystic ovary syndrome

Pfizer receives FDA approval for BOSULIF to treat Ph+ chronic myelogenous leukemia

UEA, IFR to study protective effects of broccoli consumption against prostate cancer

Alnylam announces complete results from ALN-RSV01 Phase IIb trial on RSV infection

LIN28 protein can bind directly to thousands of messenger RNAs

Researchers discover two gene variants that raise risk of pediatric cancer neuroblastoma

Epizyme commences EPZ-5676 Phase 1 study for MLL-r leukemia

More findings on genetic complexity behind type 2 diabetes

Phase 1b trial validates efficacy of Pulmatrix PUR118 to treat COPD

Fusion-negative prostate tumours display more aberrant DNA methylations

Baxter seeks FDA BLA approval for BAX 326 rFIX protein to treat hemophilia B

Regular Fanconi anemia cells aren't sensitive to resveratrol

Drugs targeting protein TGF-β may be used to treat ovarian cancer

ImmusanT commences Nexvax2 clinical trials for celiac disease in New Zealand, Australia and the U.S.

Motor coordination in children with sedentary lifestyles: an interview with Dr. Luis Lopes

Biokine, BioLineRx sign license agreement to develop and commercialize BL-8040 for AML

Ultrastable RNA nanoparticles may help treat cancer and viral infections

A-kinase anchoring proteins influence levels of glucose in the body

Converting blood cells to a stem cell state: an interview with Elias Zambidis, M.D., Ph.D.

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems