Gene News and Research

Latest Gene News and Research

New genetic animal model may inform potential therapeutic options for Down syndrome

National Institutes of Health researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be more similar to the changes seen in humans.

14 Mar 2023

Scientists find a good treatment target for pulmonary hypertension

The vascular smooth muscle cells that normally give blood vessel walls strength and flexibility proliferate and become destructive in pulmonary hypertension, a typically rapidly progressing condition that makes it hard to get blood inside our lungs and oxygen to our bodies.

14 Mar 2023

XBP1s plays a key role in controlling IL-15-mediated NK cell survival, study shows

A new study published in Science Immunology points to a promising therapeutic approach for future cancer treatments based on natural killer cells (NK), which are immune cells that bind to tumor cells and destroy them.

14 Mar 2023

Correcting abnormalities in solid tumor's blood vessels can improve efficacy of CAR-T cell therapy

A type of immune therapy called chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of multiple types of blood cancers but has shown limited efficacy against glioblastoma - the deadliest type of primary brain cancer - and other solid tumors.

14 Mar 2023

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

Researchers assessed the association between SARS-CoV-2 infection and DNA damage and cellular senescence.

14 Mar 2023

Researchers identify the mSWI/SNF chromatin remodeling complex as a host-directed drug target for SARS-CoV-2 infection

Researchers showed that mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) chromatin remodeling complexes represent a potential class of host-directed broad-acting SARS-CoV-2 therapeutic targets.

14 Mar 2023

The development of the pediatric oral resistome and its role in dental caries

Researchers performed a genomic investigation of oral resistome development, i.e., of genes that confer antimicrobial resistance.

14 Mar 2023

Hyperinflammation triggers long COVID headaches

Researchers characterize the immunological and metabolic alterations involved in chronic headache onset during post-acute sequelae of COVID-19.

13 Mar 2023

Study suggests a new way to develop intra-tumor immunotherapies to fight head and neck cancer

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health have identified a strong association between the product of a gene expressed in most cancers, including the most common type of head and neck cancer, and elevated levels of white blood cells that produce antibodies within tumors.

13 Mar 2023

Schizophrenia risk conferred by rare damaging genetic variants is conserved across ethnicities

Researchers have identified two previously unknown genes linked to schizophrenia and newly implicated a third gene as carrying risk for both schizophrenia and autism.

13 Mar 2023

High-throughput genetic screening approach to study antibiotic proteins made by bacteriophages

As conventional antibiotics continue to lose effectiveness against evolving pathogens, scientists are keen to employ the bacteria-killing techniques perfected by bacteriophages, the viruses that infect bacteria.

13 Mar 2023

Scientists study how maternal SARS-CoV-2 infection during pregnancy affects child’s brain development

Scientists led by the Lieber Institute for Brain Development are studying how a mother's SARS-CoV-2 infection during pregnancy affects the biology of the placenta and the corresponding trajectory of the child's brain development, including the risk for neurodevelopmental disorders such as schizophrenia and autism.

13 Mar 2023

Active disease process in early CTE differs substantially from late-stage disease

Millions of people, including athletes who play contact sports, members of the military and victims of domestic violence, are exposed to repetitive head impacts (RHI), which is the primary risk factor for developing chronic traumatic encephalopathy (CTE).

13 Mar 2023

Exploring airway-to-brain sensory pathways in influenza-induced illness

In a recent study published in the Nature journal, researchers assessed the role of the airway-to-brain sensory pathways in influenza-induced illness.

13 Mar 2023

Using convolutional neural network to automate the identification of chromatid cohesion defects

Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion.

13 Mar 2023

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

Researchers observe persistent SARS-CoV-2 replication in severe COVID-19 patient lungs.

13 Mar 2023

Insulin deficiency leads to reduced pancreas size in type 1 diabetes

Individuals with Type 1 diabetes have a smaller pancreas than people without diabetes. This is surprising because insulin-producing beta cells account for just a small fraction of the pancreas, so the loss of beta cells in Type 1 diabetes would not be expected to reduce pancreas size.

10 Mar 2023

Study highlights poor clinical utility of germline testing in cancer patients of African ancestry

New research in the March 2023 issue of JNCCN - Journal of the National Comprehensive Cancer Network highlights how the lack of genomic research for people with African ancestry, particularly those from the Sub-Saharan region, is hampering efforts to reduce disparities for people with cancer.

10 Mar 2023

Scientists discover how tendons and salivary glands develop in the jaw

A USC-led team of scientists has made a drool-worthy discovery about how tendons and salivary glands develop in the jaw.

10 Mar 2023

Advancing our clocks in the spring affects sleep patterns and health

If you're feeling tired this coming week, don't be surprised. Moving our clocks ahead one hour to shift into daylight saving time (which occurs at 2 a.m. Sunday) disrupts the body's biological clock, affecting sleep patterns and how we function, according to a UT Southwestern Medical Center neuroscientist who researches circadian rhythms.

10 Mar 2023

Gene News and Research

Latest Gene News and Research

New genetic animal model may inform potential therapeutic options for Down syndrome

Scientists find a good treatment target for pulmonary hypertension

XBP1s plays a key role in controlling IL-15-mediated NK cell survival, study shows

Correcting abnormalities in solid tumor's blood vessels can improve efficacy of CAR-T cell therapy

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

Researchers identify the mSWI/SNF chromatin remodeling complex as a host-directed drug target for SARS-CoV-2 infection

The development of the pediatric oral resistome and its role in dental caries

Hyperinflammation triggers long COVID headaches

Study suggests a new way to develop intra-tumor immunotherapies to fight head and neck cancer

Schizophrenia risk conferred by rare damaging genetic variants is conserved across ethnicities

High-throughput genetic screening approach to study antibiotic proteins made by bacteriophages

Scientists study how maternal SARS-CoV-2 infection during pregnancy affects child’s brain development

Active disease process in early CTE differs substantially from late-stage disease

Exploring airway-to-brain sensory pathways in influenza-induced illness

Using convolutional neural network to automate the identification of chromatid cohesion defects

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

Insulin deficiency leads to reduced pancreas size in type 1 diabetes

Study highlights poor clinical utility of germline testing in cancer patients of African ancestry

Scientists discover how tendons and salivary glands develop in the jaw

Advancing our clocks in the spring affects sleep patterns and health

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

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Advancing degrader and proximity-based drug development

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Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo