Gene News and Research

Latest Gene News and Research

Adjustable Tip Spacing Pipette Improves Productivity & Reproducibility

INTEGRA reports on a new technical note produced by Analytik Jena (www.analytik-jena.de/en.html) that compares the performance of the INTEGRA VOYAGER adjustable tip spacing multichannel pipette with a manual single channel pipette for performing real-time PCR experiments.

From INTEGRA Biosciences 17 Nov 2015

Changes in cellular metabolites regulate earliest stages of embryonic stem cell development

Changes in cellular metabolites have been shown to regulate embryonic stem cell development at the earliest stages of life. Metabolites are simple compounds generated during life-sustaining chemical activities in cells.

17 Nov 2015

Improved gene therapy treatment shows promise in mice with cystic fibrosis

An improved gene therapy treatment can cure mice with cystic fibrosis (CF). Cell cultures from CF patients, too, respond well to the treatment. Those are the encouraging results of a study presented by the Laboratory for Molecular Virology and Gene Therapy at KU Leuven, Belgium.

17 Nov 2015

MedUni Vienna researchers discover genetic cause of a rare disease

Researchers at MedUni Vienna have discovered the genetic cause of a rare disease characterized by life-threatening "liver crises" in early childhood and subsequent manifestation of neurological symptoms, such as neuropathy and ataxia (a movement disorder), when they reach school age.

15 Nov 2015

Adynovate approved for patients with Hemophilia A

The U.S. Food and Drug Administration today approved Adynovate, Antihemophilic Factor (Recombinant), PEGylated for use in adults and adolescents, aged 12 years and older, who have Hemophilia A. Adynovate is modified to last longer in the blood and potentially require less frequent injections than unmodified Antihemophilic Factor when used to reduce the frequency of bleeding.

15 Nov 2015

FDA grants accelerated approval for Tagrisso to treat patients with advanced NSCLC

Today, the U.S. Food and Drug Administration granted accelerated approval for an oral medication to treat patients with advanced non-small cell lung cancer (NSCLC). Tagrisso (osimertinib) is now approved for patients whose tumors have a specific epidermal growth factor receptor (EGFR) mutation (T790M) and whose disease has gotten worse after treatment with other EGFR-blocking therapy.

14 Nov 2015

New study provides possible way to overcome stem cell research’s developmental arrest problem

Johns Hopkins researchers report that a new study of mouse cells has revealed reasons why attempts to grow stem cells to maturity in the laboratory often fail, and provided a possible way to overcome such "developmental arrest."

13 Nov 2015

Experimental drug candidate aimed at combating Alzheimer's disease has anti-aging effects

Salk Institute researchers have found that an experimental drug candidate aimed at combating Alzheimer's disease has a host of unexpected anti-aging effects in animals.

13 Nov 2015

Mayo Clinic investigators discover novel mechanism linked to diabetes risk

Researchers at Mayo Clinic have discovered an unexpected effect from a gene known to increase diabetes risk. They assumed that the specific allele in the gene TCF7L2 which increases the risk of type 2 diabetes, impairs insulin production in response to increased insulin resistance. Some slight evidence of that was found, but more significantly the researchers discovered that this variant impaired a person's ability to balance blood sugar (glucose) by suppressing glucagon - the hormone that raises the level of glucose in the bloodstream.

12 Nov 2015

Baylor Miraca Genetics Laboratories licenses SNP probe technology from OGT

Oxford Gene Technology (OGT), The Molecular Genetics Company, has entered into a deal with Baylor Miraca Genetics Laboratories (BMGL), licensing the use of OGT’s proprietary single nucleotide polymorphism (SNP) array probe technology.

From Oxford Gene Technology 12 Nov 2015

Some antibiotics may make MRSA more harmful

Treating MRSA with certain first-line antibiotics can actually make MRSA skin infections worse, according to a study published in Cell Host & Microbe.

12 Nov 2015

UCSF-led researchers map out melanoma's genetic trajectories

An international team of scientists led by UC San Francisco researchers has mapped out the genetic trajectories taken by melanoma as it evolves from early skin lesions, known as precursors, to malignant skin cancer, which can be lethal when it invades other tissues in the body.

12 Nov 2015

CHOP researchers delay symptoms, extend lifespan in animal model of Batten disease

Researchers have taken a significant step forward in developing gene therapy against a fatal neurodegenerative disease that strikes children. By delivering a working version of a gene to produce a key enzyme that is lacking in Batten disease, the scientists delayed symptoms and extended lifespan in dogs with a comparable disease.

12 Nov 2015

Moffitt Cancer Center study finds link between common gene mutations and tumor immune surveillance

Learning if a lung cancer patient has genetic mutations can help oncologists determine the best approach to treatment. There are four gene mutations (KRAS, TP53, STK11, and EGFR) that most commonly occur in lung cancer; however, there are limited effective therapies to target these mutations. With this in mind, Moffitt Cancer Center performed an extensive genetic analysis of lung cancer specimens to unravel how mutations in the two of those genes (TP53 and STK11) contribute to the biology of lung cancer and patient outcomes.

12 Nov 2015

Researchers demonstrate new screening model to identify drug targets for the most lethal strain of malaria

A University of South Florida Center for Global Health & Infectious Diseases Research team has demonstrated a new screening model to classify antimalarial drugs and to identify drug targets for the most lethal strain of malaria, Plasmodium falciparum.

12 Nov 2015

ApoE4-carrying men with Alzheimer's disease at risk of brain bleeds

A common genetic variation, ApoE4, linked to Alzheimer's disease greatly raises the likelihood of tiny brain bleeds in some men, scientists have found.

12 Nov 2015

March of Dimes scientists help fine-tune experiments to uncover unknown causes of preterm birth

A new, integrated online database of genes and other information related to pregnancy has been developed by March of Dimes Prematurity Research Center investigators to help fine-tune questions, theories, and experiments to uncover the unknown causes of preterm birth.

12 Nov 2015

Crucial change in single DNA base predisposes children to aggressive form of cancer

Pediatric oncology researchers have pinpointed a crucial change in a single DNA base that both predisposes children to an aggressive form of the childhood cancer neuroblastoma and makes the disease progress once tumors form.

12 Nov 2015

Study shows rare HER2 missense mutations do not spread breast cancer on their own

Results of a new laboratory study by Johns Hopkins Kimmel Cancer Center researchers suggests that some rare “missense” mutations in the HER2 gene are apparently not — on their own — capable of causing breast cancer growth or spread.

12 Nov 2015

Boston Children's Hospital selects Vijay G. Sankaran to receive Rising Star Award

Saluting his spectacular track record to date of innovative research on red blood cell disorders and his future promise as a physician/scientist, Boston Children's Hospital has selected Vijay G. Sankaran, MD, PhD, of Dana-Farber/Boston Children's Cancer and Blood Disorders Center to receive the Rising Star Award at the hospital's third annual Global Pediatric Innovation Summit, Taking on Tomorrow (#PedInno15).

11 Nov 2015

Gene News and Research

Latest Gene News and Research

Adjustable Tip Spacing Pipette Improves Productivity & Reproducibility

Changes in cellular metabolites regulate earliest stages of embryonic stem cell development

Improved gene therapy treatment shows promise in mice with cystic fibrosis

MedUni Vienna researchers discover genetic cause of a rare disease

Adynovate approved for patients with Hemophilia A

FDA grants accelerated approval for Tagrisso to treat patients with advanced NSCLC

New study provides possible way to overcome stem cell research’s developmental arrest problem

Experimental drug candidate aimed at combating Alzheimer's disease has anti-aging effects

Mayo Clinic investigators discover novel mechanism linked to diabetes risk

Baylor Miraca Genetics Laboratories licenses SNP probe technology from OGT

Some antibiotics may make MRSA more harmful

UCSF-led researchers map out melanoma's genetic trajectories

CHOP researchers delay symptoms, extend lifespan in animal model of Batten disease

Moffitt Cancer Center study finds link between common gene mutations and tumor immune surveillance

Researchers demonstrate new screening model to identify drug targets for the most lethal strain of malaria

ApoE4-carrying men with Alzheimer's disease at risk of brain bleeds

March of Dimes scientists help fine-tune experiments to uncover unknown causes of preterm birth

Crucial change in single DNA base predisposes children to aggressive form of cancer

Study shows rare HER2 missense mutations do not spread breast cancer on their own

Boston Children's Hospital selects Vijay G. Sankaran to receive Rising Star Award

eBook: Using iPSCs models for human disease research and drug discovery eBook

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich