Immunotherapy News and Research

Latest Immunotherapy News and Research

Novel T cell receptor therapy shows early promise for treating solid tumors

Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), an adoptive T cell receptor (TCR) therapy targeting the MAGE-A4 cancer antigen, achieved clinically significant results for patients with multiple solid tumor types in a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

9 Jan 2023

Is universal coronavirus immunity possible?

In a recent study posted to the bioRxiv* preprint server, researchers at Columbia University characterized reciprocal and non-reciprocal T-cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

8 Jan 2023

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

A new research paper was published in Oncotarget's Volume 13 on December 20, 2022, entitled, "Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression."

6 Jan 2023

Study details the “immunometabolic editing” mechanism of tumor evolution

A Ludwig Cancer Research study has discovered that the immune system's surveillance of cancer can itself induce metabolic adaptations in the cells of early-stage tumors that simultaneously promote their growth and equip them to suppress lethal immune responses.

5 Jan 2023

New dual-action, cancer-killing vaccine tested in an advanced mouse model of glioblastoma

Scientists are harnessing a new way to turn cancer cells into potent, anti-cancer agents. In the latest work from the lab of Khalid Shah, MS, PhD, at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, investigators have developed a new cell therapy approach to eliminate established tumors and induce long-term immunity, training the immune system so that it can prevent cancer from recurring.

4 Jan 2023

Distinct genomic patterns of malignant peripheral nerve sheath tumors may help with early diagnosis

Neurofibromatosis type 1 (NF1) is a common genetic condition, affecting 1 in 3000 individuals, and people with NF1 are at greater risk of developing a rare, aggressive form of cancer.

4 Jan 2023

Novel triple immunotherapy combination improves anti-tumor responses in preclinical models of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with poor prognosis and limited treatment options.

3 Jan 2023

Novel approach may prevent antibodies from triggering immune rejection of transplant cells

Researchers at UCSF have developed a novel, potentially life-saving approach that may prevent antibodies from triggering immune rejection of engineered therapeutic and transplant cells.

2 Jan 2023

Study suggests a strategy for preventing the progression of chronic leukemia to aggressive disease

A study from Washington University School of Medicine in St. Louis suggests a strategy for preventing a chronic, slow-growing type of blood cancer from progressing to an aggressive form of leukemia.

29 Dec 2022

NCI-led clinical trial results in the first approval of a treatment for advanced alveolar soft part sarcoma

A clinical trial led by the National Cancer Institute (NCI), part of the National Institutes of Health, has resulted in the first approval of a treatment for advanced alveolar soft part sarcoma (ASPS).

28 Dec 2022

Wafer-thin device could drastically alter the course of treatment for Type 1 diabetes

A quarter-sized device created at Houston Methodist could drastically alter the course of treatment for Type 1 diabetes, a chronic condition that impacts millions of Americans and does not have a cure.

27 Dec 2022

High ammonia levels lead to fewer T cells and immunotherapy resistance in colorectal cancer

High levels of ammonia in tumors lead to fewer T cells and immunotherapy resistance in mouse models of colorectal cancer, new findings from the University of Michigan Rogel Cancer Center revealed.

23 Dec 2022

Researchers present a new strategy for self-adjuvanting vaccine development

This new article publication from Acta Pharmaceutica Sinica B, discusses a fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development.

23 Dec 2022

Plasma GH is a biomarker candidate for predicting outcomes in advanced HCC patients treated with Atezo/Bev

A new research paper was published in Oncotarget's Volume 13 on December 6, 2022, entitled, "Plasma growth hormone is a potential biomarker of response to atezolizumab and bevacizumab in advanced hepatocellular carcinoma patients."

22 Dec 2022

Extracellular vesicles enhance cancer immunotherapy

Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumors sensitive to a type of immunotherapy drug called a checkpoint inhibitor.

22 Dec 2022

Impact of epigenetics on the clinical management of cancer patients

Dr. Manel Esteller and Dr. Verónica Dávalos, researchers at the Josep Carreras Leukaemia Research Institute, describe in a new article the impact of epigenetics on cancer treatment and how it has become a crucial tool to improve early detection, predict disease progression and become a target for new treatments.

22 Dec 2022

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

The Spanish Agency of Medicines and Medical Products (AEMPS) has approved the CARxALL clinical trial led by the company OneChain Immunotherapeutics (OCI).

21 Dec 2022

ACAAI’s two new yardsticks on managing eosinophilic esophagitis and cough published

Beginning in 2016, the American College of Allergy, Asthma and Immunology (ACAAI) began developing a series of yardsticks to help practitioners better understand the range of treatments available for allergic conditions.

21 Dec 2022

Analysis finds more than 100 new genetic risk factors strongly linked to colorectal cancer

A comprehensive analysis of more than 100,000 colorectal cancer (CRC) cases, led by researchers at the Fred Hutchinson Cancer Center in Seattle and 200 scientific collaborators worldwide, has identified more than 100 new genetic risk factors strongly linked with the disease.

20 Dec 2022

CU study proves effectiveness of new multidrug treatment for patients with stage IV melanoma

A new multidrug treatment for patients with stage IV melanoma has proven effective after a three-year clinical trial at the University of Colorado Cancer Center.

16 Dec 2022

Immunotherapy News and Research

Latest Immunotherapy News and Research

Novel T cell receptor therapy shows early promise for treating solid tumors

Is universal coronavirus immunity possible?

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

Study details the “immunometabolic editing” mechanism of tumor evolution

New dual-action, cancer-killing vaccine tested in an advanced mouse model of glioblastoma

Distinct genomic patterns of malignant peripheral nerve sheath tumors may help with early diagnosis

Novel triple immunotherapy combination improves anti-tumor responses in preclinical models of pancreatic cancer

Novel approach may prevent antibodies from triggering immune rejection of transplant cells

Study suggests a strategy for preventing the progression of chronic leukemia to aggressive disease

NCI-led clinical trial results in the first approval of a treatment for advanced alveolar soft part sarcoma

Wafer-thin device could drastically alter the course of treatment for Type 1 diabetes

High ammonia levels lead to fewer T cells and immunotherapy resistance in colorectal cancer

Researchers present a new strategy for self-adjuvanting vaccine development

Plasma GH is a biomarker candidate for predicting outcomes in advanced HCC patients treated with Atezo/Bev

Extracellular vesicles enhance cancer immunotherapy

Impact of epigenetics on the clinical management of cancer patients

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

ACAAI’s two new yardsticks on managing eosinophilic esophagitis and cough published

Analysis finds more than 100 new genetic risk factors strongly linked to colorectal cancer

CU study proves effectiveness of new multidrug treatment for patients with stage IV melanoma

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Immunotherapy News and Research

Latest Immunotherapy News and Research

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