Immunotherapy

Immunotherapy is the concept of using the immune system to treat disease, for example, developing a vaccine against cancer. Immunotherapy may also refer to the therapy of diseases caused by the immune system, allergies for example.

What is Immunotherapy?

Immunotherapy is a treatment that is designed to harness the ability of the body’s immune system to combat infection or disease.

Activation Immunotherapies

Adoptive T Cell Therapy Methodology

Immunotherapy: The Future of Lung Cancer Treatment?

Neoantigens' Role in Immunotherapy

Suppression Immunotherapies

Adoptive T Cell Therapy Applications

Immunotherapy and Helminthic Therapy

Immunotherapy: Past, Present and Future

Latest Immunotherapy News and Research

Polymeric nanomedicine strategies improve solid tumor immunotherapy outcomes

Solid tumors are not merely collections of malignant cells but complex ecosystems comprising tumor cells, stromal cells, and the extracellular matrix (ECM).

9 Oct 2026

FDA approves atezolizumab combination for stage III colon cancer with deficient DNA mismatch repair

The Alliance for Clinical Trials in Oncology (Alliance) today announced that the U.S. Food and Drug Administration has approved the immunotherapy drug atezolizumab (Tecentriq) in combination with fluoropyrimidine and oxaliplatin chemotherapy, for the adjuvant treatment of patients with stage III colon cancer with deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR).

9 Oct 2026

Study explains why cancer immunity declines faster in males

Lutz Menzel, PhD, formerly of the Department of Radiation Oncology within the Mass General Brigham Cancer Institute, and Tim Padera, PhD, currently of the Mass General Brigham Cancer Institute, are the lead and senior authors of a paper published in Nature Aging, "Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age."

9 Oct 2026

New research unveils role of innate immune system in pancreatic cancer

Researchers from Adelaide University have demonstrated that blocking a specific immune system gene can reduce pancreatic cancer tumor formation.

9 Oct 2026

Rare dendritic cells may promote immune tolerance in metastatic cancer

This study was co-led by Steven Blum, MD. Gary Reynolds, MD, PhD, Samuel Klempner, MD, and Alexandra-Chloé Villani, PhD, jointly supervised the work at the Krantz Family Center for Cancer Research within the Mass General Brigham Cancer Institute and the Mass General Brigham Center for Immunology & Inflammatory Diseases (CIID).

8 Oct 2026

Disrupted circadian rhythms may influence tumor immunity and cancer spread

Epidemiological studies link light at night (LAN), shift work, chronic jet lag (CJL), and core clock gene mutations to higher cancer risk and aggressive spread, especially in breast and colorectal cancer.

8 Oct 2026

Combination therapy overcomes immunotherapy resistance in glioblastoma

Scientists at The Wistar Institute have identified a combination treatment that overcomes two of the biggest barriers to immunotherapy in glioblastoma.

8 Oct 2026

A New Approach to Preventing Bladder Cancer Recurrence

Innovative techniques using electrical energy to treat bladder cancer may lower recurrence rates and minimize the need for radical surgical interventions.

8 Oct 2026

Single tRNA controls prostate cancer identity and treatment resistance

Researchers at Fred Hutch Cancer Center have identified a previously overlooked molecular regulator that helps determine whether prostate tumors remain sensitive to treatment or evolve into a more aggressive, drug-resistant form of the disease.

7 Oct 2026

Scientists discover a novel strategy to unmask cancer cells in high-risk neuroblastoma

High-risk neuroblastoma is one of the most aggressive forms of solid tumors affecting children, originating in the nervous system.

6 Oct 2026

Cigarette smoke alters lung stem cells to drive specific cancers

Chronic exposure to cigarette smoke may reprogram different populations of lung stem cells, which maintain and repair lung tissue, in ways that make them vulnerable to specific cancer-causing gene alterations and ultimately helps determine the type of lung cancer that develops.

6 Oct 2026

Terumo Blood and Cell Technologies partners with TrAMPoline Pharma to automate TIL therapy manufacturing for solid tumors

Terumo Blood and Cell Technologies (Terumo BCT), a medical technology company advancing blood- and cell-based therapies worldwide, has entered a research collaboration with TrAMPoline Pharma and Eduardo Davila, PhD, at the University of Colorado to develop an automated manufacturing approach for tumor-infiltrating lymphocyte (TIL) therapies targeting solid tumors.

6 Oct 2026

Before the first bite: A missing gut protein may set the stage for peanut allergy

For most people, a peanut butter sandwich poses no threat. But for the roughly 1.6 million children in the United States with peanut allergy, exposure can trigger a life-threatening reaction.

6 Oct 2026

Tailored treatments allow less invasive surgery for breast cancer patients

For many patients diagnosed with breast cancer, the first instinct may be to pursue the most aggressive treatment possible.

5 Oct 2026

Simple urine test can accurately diagnose and track bladder cancer

A simple urine test devised by researchers at Stanford Medicine and the VA Palo Alto Health Care System can diagnose people with bladder cancer more accurately than current standard methods.

5 Oct 2026

Sex chromosomes influence immunity, cancer, aging and disease risk

A new review published in Science brings together growing evidence that the X and Y chromosomes do much more than determining biological sex. They also shape how cells function, age and respond to disease.

1 Oct 2026

Phage proteases activate bacterial immune response to viral infection

In the fight to find better treatments for bacterial infections, one rapidly evolving therapy is a group of viruses called bacteriophages (phages). Phages can attack and kill dangerous bacteria while leaving human cells unharmed and bypassing antibiotic resistance.

1 Oct 2026

New mathematical model tracks how tumor environment impacts cancer therapies

Researchers from Mass General Brigham and the University of Cyprus have developed a sophisticated mathematical model to better understand how the tumor microenvironment affects the delivery and effectiveness of a new type of cancer therapy called an immunomodulatory antibody-drug conjugate (IM-ADC).

30 Sep 2026

Blood tests can identify cancer neoantigens for personalized immunotherapy

Cancer neoantigens and neoantigen-specific T cells were identified from patient blood samples by analyzing circulating tumor DNA (ctDNA) and immune cells, respectively, and they largely matched those found through traditional tumor tissue biopsy in many patients.

29 Sep 2026

Scientists find new way to overcome cell’s natural defenses against self-amplifying mRNA vaccines

The innovation could enable protection at lower doses, meaning vaccines could be rolled out further and faster than was previously imaginable, and opens new possibilities in gene therapy, cancer immunotherapy, and protein replacement therapies.

28 Sep 2026