Immunotherapy News and Research

Latest Immunotherapy News and Research

New 'GLed' tool enables real-time monitoring of T cell activity

The new 'GLed' tool, unique in its reversibility, allows the functional state of T cells to be observed for the first time, representing a crucial advance in personalizing treatments in immunotherapy, transplants, and autoimmune diseases.

30 Sep 2025

Stereotactic radiotherapy offers long-term survival outcomes comparable to surgery for NSCLC patients

A new clinical trial report finds that stereotactic radiation therapy offers long-term survival outcomes comparable to surgery for patients with small, early-stage non-small cell lung cancer (NSCLC). Patients in the study who received radiation also reported fewer side effects after treatment.

30 Sep 2025

Radiomics significantly outperforms clinical models for predicting NPC treatment outcome

Nasopharyngeal carcinoma (NPC) is a highly aggressive malignancy, with most patients presenting at locally advanced stages. While immune checkpoint inhibitors, such as PD-1 blockade, have reshaped treatment strategies, only a minority of patients achieve durable benefit. Accurate biomarkers for predicting treatment response remain an urgent unmet need.

30 Sep 2025

Post-operative radiation therapy reduces pelvic relapse in high-risk bladder cancer

Radiation therapy could be an underused tool to reduce pelvic relapse risk for patients with locally advanced, muscle-invasive bladder cancer, according to results of a new phase III randomized trial.

29 Sep 2025

Small molecule AVJ16 shows promise in targeting lung cancer growth

Researchers have discovered a promising new approach to lung cancer treatment. A small molecule called AVJ16 selectively blocks the cancer-driving protein IGF2BP1, halting tumor growth in preclinical studies and killing cancer cells in patient-derived models—while leaving healthy cells unharmed.

29 Sep 2025

Novel treatment disrupts tumor immunosuppression in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with a five-year survival rate below 10%.

26 Sep 2025

New T cell therapy targets CTNNB1 cancer mutation with promising results in animal studies

Researchers at the University of Oslo and Oslo University Hospital have developed a promising new immunotherapy targeting the CTNNB1 gene mutation associated with various aggressive cancers like lung and prostate cancer.

26 Sep 2025

Loss of Trp53 gene affects immune responses in ovarian cancer

A new research paper was published in Volume 16 of Oncotarget on September 22, 2025, titled "Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma."

24 Sep 2025

Scientists outline how future therapies could change type 1 diabetes care

Researchers writing in The Lancet review breakthroughs in type 1 diabetes treatment, from immunotherapies that delay onset to stem-cell β-cell replacement and automated insulin delivery. They stress that equitable access, validated surrogate endpoints, and scalable technologies are crucial for lasting impact.

24 Sep 2025

SynGenSys introduces NK.SET synthetic promoter library to advance natural killer cell therapies

SynGenSys, a biotechnology company designing synthetic gene promoter systems to address critical bottlenecks in biopharma manufacturing and enhance cell and gene therapy development, today announced the launch of NK.SET™.

23 Sep 2025

PRMT5 inhibition induces ferroptosis and enhances immunotherapy efficacy in renal cell carcinoma

Ferroptosis, a regulated cell death mechanism, is emerging as a promising target for cancer therapy. The process is mediated by the activity of acyl-CoA synthetase family member 4 (ACSL4) protein.

22 Sep 2025

Study identifies immune biomarkers for personalized therapies in pediatric germ cell tumors

A study conducted by the Molecular Oncology Research Center (CPOM) at Hospital de Amor in Barretos (formerly Barretos Cancer Hospital) in the state of São Paulo, Brazil, has identified possible biomarkers that could guide the development of more personalized therapies for pediatric germ cell tumors (GCTs).

18 Sep 2025

PANoptosis emerges as a promising strategy against liver cancer

Liver cancer, particularly hepatocellular carcinoma (HCC), remains one of the deadliest cancers, driven by high recurrence and resistance to therapy.

18 Sep 2025

New molecule offers a more targeted and potent immunotherapy

A newly developed molecule brings together two powerful immunotherapy strategies in one treatment. Researchers at the University of Basel and University Hospital Basel, Switzerland, have demonstrated that this fusion protein can both block the "do not attack" signal used by cancer cells and selectively activate tumor-fighting immune cells. This dual action could pave the way for more effective cancer therapies with fewer side effects.

18 Sep 2025

The 15th AACR cancer progress report highlights scientific advances

The American Association for Cancer Research (AACR) released the 15th edition of its annual Cancer Progress Report. A cornerstone of the AACR's educational and advocacy efforts, this comprehensive report provides the latest statistics on cancer incidence, mortality, and survivorship and highlights how federal investments in basic, translational, and clinical cancer research and cancer-related population sciences have led to impressive scientific advances that are improving health and saving lives.

17 Sep 2025

New findings show lymph nodes educate T cells to combat disease

A team of researchers, led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute), explored the cellular and molecular interactions revealing how lymph nodes play a crucial role in the fight against chronic infection and cancer.

17 Sep 2025

CRISPR-GPT helps scientists to generate designs, analyze data and troubleshoot design flaws

Stanford Medicine researchers have developed an artificial intelligence tool to help scientists better plan gene-editing experiments.

16 Sep 2025

Triple negative breast cancer exploits lymph node niches to block immune defense

In almost all solid tumors - i.e. cancers with a solid tissue structure - the detection of tumor cells in the lymph nodes is considered a decisive marker for the progression of the disease.

16 Sep 2025

Targeting telomere damage offers new path to boost cancer immunotherapy

Tumors are stressful places for cancer-fighting immune cells. Low oxygen, high acid levels, and other stressors put strain on mitochondria, the cell's energy factories, leading to T cell exhaustion and poor cancer outcomes.

10 Sep 2025

Lung tumors rewire immune cells in the bone marrow before they reach cancer sites

Lung tumors don't just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy

10 Sep 2025

Immunotherapy News and Research

Latest Immunotherapy News and Research

New 'GLed' tool enables real-time monitoring of T cell activity

Stereotactic radiotherapy offers long-term survival outcomes comparable to surgery for NSCLC patients

Radiomics significantly outperforms clinical models for predicting NPC treatment outcome

Post-operative radiation therapy reduces pelvic relapse in high-risk bladder cancer

Small molecule AVJ16 shows promise in targeting lung cancer growth

Novel treatment disrupts tumor immunosuppression in pancreatic cancer

New T cell therapy targets CTNNB1 cancer mutation with promising results in animal studies

Loss of Trp53 gene affects immune responses in ovarian cancer

Scientists outline how future therapies could change type 1 diabetes care

SynGenSys introduces NK.SET synthetic promoter library to advance natural killer cell therapies

PRMT5 inhibition induces ferroptosis and enhances immunotherapy efficacy in renal cell carcinoma

Study identifies immune biomarkers for personalized therapies in pediatric germ cell tumors

PANoptosis emerges as a promising strategy against liver cancer

New molecule offers a more targeted and potent immunotherapy

The 15th AACR cancer progress report highlights scientific advances

New findings show lymph nodes educate T cells to combat disease

CRISPR-GPT helps scientists to generate designs, analyze data and troubleshoot design flaws

Triple negative breast cancer exploits lymph node niches to block immune defense

Targeting telomere damage offers new path to boost cancer immunotherapy

Lung tumors rewire immune cells in the bone marrow before they reach cancer sites

eBook: Cell-based technologies in drug discovery and Immunotherapy eBook

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics

Immunotherapy News and Research

Latest Immunotherapy News and Research

eBook: Cell-based technologies in drug discovery and Immunotherapy eBook

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics

Newsletters you may be interested in