CONSUMER MEDICINE INFORMATION
What is in this leaflet
This leaflet answers some common questions about Lumin.
It does not contain all of the available information. It does not take the place of
talking to your doctor or pharmacist.
All medicines have benefits and risks. Your doctor has weighed the risks of you taking
Lumin against the benefits expected for you.
If you have any concerns about taking this medicine, talk to your doctor or pharmacist.
Keep this leaflet with your medicine.
You may need to read it again.
What Lumin is used for
Lumin is used to treat depression.
Lumin is an antidepressant, which works by acting on chemicals in your brain called
amines. These amines are involved in controlling mood.
Ask your doctor if you have any questions about why Lumin has been prescribed for
Your doctor may have prescribed Lumin for another reason.
Lumin is not approved for use in children and adolescents below 18 years of age for
the treatment of depression or other mental disorders.
The safe use and effectiveness of Lumin in treating these disorders, for this age
group, has not been established.
Lumin is available only with a doctor's prescription.
Before you take Lumin
When you must not take it
Do not take Lumin if you are allergic to:
medicines containing mianserin hydrochloride (e.g. Tolvon)
any of the ingredients listed at the end of this leaflet
Some of the symptoms of an allergic reaction may include skin rash, itching or hives,
swelling of the face, lips, mouth, throat or other parts of the body, shortness of
breath, wheezing or troubled breathing.
Check with your doctor or pharmacist if you are not sure about any of the above.
Do not take Lumin if you:
suffer from mania, a mental condition characterised by episodes of overactivity, elation
have severe liver disease
Do not take Lumin if you are taking another medicine for depression called a monoamine
oxidase inhibitor (MAOI), or have been taking an MAOI within the last 14 days. If
you stop taking Lumin, do not take MAOI during the next 2 weeks either.
Taking Lumin with an MAOI may cause a serious reaction with a sudden increase in body
temperature, extremely high blood pressure and severe convulsions.
Ask your doctor or pharmacist if you are not sure if you are taking, or have been
taking a MAOI.
MAOIs are medicines used to treat depression and symptoms of Parkinson's disease.
Examples of MAOIs are phenelzine (Nardil), tranylcypromine (Parnate), moclobemide
(e.g. Aurorix, Arima), selegiline (Eldepryl, Selgene) and linezolid (Zyvox).
Do not take Lumin if the packaging shows signs of tampering or the tablets do not
look quite right.
Do not take Lumin if the expiry date (EXP) printed on the pack has passed.
If you take this medicine after the expiry date, it may not work as well.
Talk to your doctor if you are not sure whether you should start taking this medicine.
Before you start to take it
Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.
Tell your doctor if you are pregnant or plan to become pregnant.
Your doctor will discuss the risks and benefits of taking Lumin during pregnancy.
Tell your doctor if you are breastfeeding or wish to breastfeed.
It is not known whether Lumin passes into breast milk.
Your doctor will discuss the risks and benefits of taking Lumin when breastfeeding.
Tell your doctor if you have or have had any of the following medical conditions:
blood pressure problems
heart disease, including certain kinds of heart conditions that change your heart
rhythm, a recent heart attack, heart failure, or taking certain medicines known to
change heart rhythm
liver problems (e.g. jaundice)
any mental illness other than depression
epilepsy, (fits or convulsions)
glaucoma, (increased pressure in the eye)
problems with urinating due to an enlarged prostate.
Mental illness such as schizophrenia and manic depression (alternating periods of
elation/overactivity and depressed mood).
If you have not told your doctor about any of the above, tell him/her before you start
Taking other medicines
Do not take Lumin if you are taking any monoamine oxidase inhibitor (MAOI) such as:
phenelzine (Nardil) and tranylcypromine (Parnate), moclobemide (eg. Aurorix, Arima),
used to treat depression
selegiline (Eldepryl, Selgene), used to treat symptoms of Parkinson's disease.
Wait at least 14 days after stopping your MAOI before starting Lumin.
Tell your doctor if you are taking any other medicines, including any that you buy
with or without a prescription from a pharmacy, supermarket or health food shop.
Some medicines may be affected by Lumin or may affect how well it works. These include:
other medicines for depression
Monoamine Oxidase Inhibitors (MAOIs)
medicines used to treat epilepsy such as barbiturates, carbamazepine and phenytoin
medicines used to treat high blood pressure
oral antidiabetic medicines or insulin
medicines used to prevent blood clots, such as warfarin.
medicines that may affect the heart rhythm such as certain antibiotics and some anti-psychotics.
Your doctor can tell you what to do if you are taking any of these medicines.
If you are not sure whether you are taking any of these medicines, check with your
doctor or pharmacist.
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while taking Lumin.
How to take Lumin
Follow all directions given to you by your doctor and pharmacist carefully.
They may differ from the information contained in this leaflet.
If you do not understand the instructions on the pack, ask your doctor or pharmacist.
How much to take
Your doctor will tell you how much Lumin to take each day. Take exactly the amount
your doctor tells you to.
The dose varies from patient to patient.
Your doctor will decide the right dose for you. This depends on your condition, age,
whether or not you are taking any other medicines, and how you respond to Lumin.
Lumin is usually started at a low dose, at 30mg per day. This may be given as a single
night-time dose before going to bed or given in three divided doses. Your doctor may
slowly increase this dose depending on how you respond to Lumin. The effective dose
for most people is usually between 30mg and 90mg per day.
The usual starting dose will not be more than 30mg per day. Your doctor may slowly
increase or decrease your dose, depending on how you respond to Lumin.
If you do not understand the instructions on the pack, ask your doctor or pharmacist.
How to take it
Swallow the tablets whole with a glass of water. Do not chew the tablets.
When to take it
Lumin should be taken between meals.
Lumin can be taken as a single dose (eg. at bedtime) or as divided doses (eg. three
times a day). Your doctor will advise you.
Take your medicine at about the same time each day.
Taking it at the same time each day will have the best effect. It will also help you
remember when to take it.
How long to take it for
Keep taking Lumin for as long as your doctor recommends.
The length of treatment will depend on how quickly your symptoms improve.
Most medicines for depression take time to work, so do not be discouraged if you do
not feel better right away. Some of your symptoms may improve in 1 or 2 weeks but
it can take up to 4 or 6 weeks to feel the full benefit of Lumin.
Even when you feel well, you will usually have to take Lumin for several months or
longer, to make sure the benefits will last.
If you forget to take it
IF YOU TAKE ONE DOSE A DAY AT BEDTIME:
If you forget to take Lumin before you go to bed and you wake up late in the night
or early in the morning, do not take any Lumin until you have checked with your doctor.
You may have difficulty waking up or experience drowsiness in the morning or during
the day, if you take Lumin at these times.
IF YOU TAKE MORE THAN ONE DOSE A DAY:
If it is almost time for your next dose, skip the dose you missed and take your next
dose when you are meant to.
Otherwise, take the missed dose as soon as you remember, and then go back to taking
your tablets as you would normally.
Do not take a double dose to make up for the dose you missed.
If you are not sure what to do, ask your doctor or pharmacist.
If you take too much (overdose)
Immediately telephone your doctor or the Poisons Information Centre (telephone 13
11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you
think you or anyone else may have taken too much Lumin.
Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
If you take too much Lumin, you may feel drowsy, dizzy and lightheaded, have changes
in heart rate (fast, slow or irregular), and/or fainting which could be symptoms of
a life-threatening condition known as Torsades de Pointes. You may also have fits
and problems breathing.
Keep Lumin out of the reach of children.
Children are much more sensitive than adults to medicines such as Lumin. An accidental
overdose is especially dangerous.
While you are taking Lumin
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are taking Lumin.
Tell all the doctors, dentists and pharmacists who treat you that you are taking this
Tell your doctor immediately if you have any suicidal thoughts or other mental/mood
Occasionally, the symptoms of depression or other psychiatric conditions may include
thoughts of harming yourself or committing suicide. These symptoms may continue or
get worse during the first one to two months of treatment until the full antidepressant
effect of the medicine becomes apparent.
Information from clinical trials have shown an increased risk of suicidal behaviour
in young adults aged less than 25 years with psychiatric conditions who were treated
with an antidepressant.
Contact your doctor or a mental health professional right away or go to the nearest
hospital for treatment if you or someone you know is showing any of the following
warning signs of suicide:
worsening of your depression
thoughts or talk of death or suicide
thoughts or talk of self-harm or harm to others
any recent attempts of self-harm
increase in aggressive behaviour, irritability or any other unusual changes in behaviour
All mentions of suicide or violence must be taken seriously.
You may find it helpful to tell a relative or close friend that you are depressed
or have an anxiety disorder, and ask them to read this leaflet. You might ask them
to tell you if they think your depression or anxiety is getting worse, or if they
are worried about changes in your behaviour.
Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed.
Otherwise, your doctor may think that it was not effective and change your treatment
Tell your doctor if you feel Lumin is not helping your condition.
Keep all of your appointments with your doctor so that your progress can be checked.
You may need to have blood tests from time to time.
Tell your doctor immediately if you develop fever, chills, sore throat or mouth ulcers
or other signs of frequent infections.
In rare cases, Lumin can cause a shortage of white blood cells, resulting in the lowering
of the body resistance to infection. These symptoms may appear after 4-6 weeks of
Tell your doctor immediately if you become pregnant while taking Lumin. Do not stop
taking your tablets until you have spoken to your doctor.
If you are going to have surgery, tell the surgeon or anaesthetist that you are taking
Things you must not do
Do not drive or operate machinery until you know how Lumin affects you.
Lumin may cause drowsiness, dizziness, lightheadedness, sleepiness or affect concentration
in some people. If any of these occur, do not drive, operate machinery or do anything
else that could be dangerous.
Do not suddenly stop taking Lumin or lower the dose without first checking with your
doctor. Do not let yourself run out of tablets over the weekend or on holidays.
If you suddenly stop taking Lumin, you may feel unwell, sick in the stomach or have
Your doctor will tell you how to gradually reduce the amount of Lumin you are taking
before stopping completely.
Do not stop taking Lumin even if you feel better unless advised by your doctor.
Do not use Lumin to treat any other conditions unless your doctor tells you to.
Do not give Lumin to anyone else, even if they have the same condition as you.
Things to be careful of
Do not drink alcohol while taking Lumin.
Combining alcohol with Lumin can make you more drowsy, dizzy or lightheaded. Your
doctor may suggest you avoid alcohol while being treated with Lumin.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking Lumin.
Lumin helps most people with depression, but it may have unwanted side effects in
All medicines can have side effects. Sometimes they are serious, most of the time
they are not. You may need medical treatment if you get some of the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
Tell your doctor if you notice any of the following and they worry you:
tiredness, drowsiness or lack of energy
dizziness on standing up, especially when getting up from a sitting or lying down
breast enlargement in men
ringing or persistent noise in the ears
hepatitis (inflammation of the liver)
Tell your doctor as soon as possible if you notice any of the following:
tingling or numbness of the hands or feet
painful, swollen joints
aching muscles, muscle tenderness or weakness, not caused by exercise
sudden switch of mood to one of excitement, overactivity, talkativeness and uninhibited
confusion, agitation, irritability, hostility (aggressiveness), unusual changes in
Tell your doctor immediately or go to Accident and Emergency at the nearest hospital
if you notice any of the following:
you have thoughts of harming or killing yourself
signs of frequent infections such as fever, chills, sore throat or mouth ulcers
bruising or bleeding more easily than normal, nosebleeds
tiredness, headaches, being short of breath when exercising
fits or convulsions
yellowing of the eyes or skin (jaundice)
slow heart beat
changes to your heart rhythm (fast, irregular heartbeat) and/or fainting which could
be symptoms of a life-threatening condition known as Torsades de Pointes
shortness of breath (sometimes with tiredness, weakness and reduced ability to exercise),
which may occur together with swelling of the feet or legs due to fluid build up
stiffness in the body, involuntary movements, a sudden increase in body temperature,
extremely high blood pressure and severe convulsions (Neuroleptic Malignant Syndrome).
Tell your doctor if you notice anything that is making you feel unwell.
Other side effects not listed above may also occur in some people.
After using Lumin
Keep Lumin where children cannot reach it.
A locked cupboard a least one-and-a-half metres above the ground is a good place to
Keep your tablets in a cool dry place where the temperature stays below 30°C. Protect
Do not store Lumin or any other medicine in the bathroom or near a sink.
Do not leave Lumin in the car or on window sills.
Heat and dampness can destroy some medicines.
If your doctor tells you to stop taking Lumin, or your tablets have passed their expiry
date, ask your pharmacist what to do with any that are left over.
Medicines should not be disposed of via wastewater or household waste. These measures
will help protect the environment.
What it looks like
Lumin is available in 2 strengths:
Lumin 10 - round, white tablet, marked "MI 10" on one side and "G" on the other side
Lumin 20 - round, white tablet, marked "MI 20" on one side and "G" on the other side.
Each pack contains 50 tablets.
The active ingredient in Lumin is mianserin (as mianserin hydrochloride):
each Lumin 10 tablet contains 10 mg of mianserin hydrochloride
each Lumin 20 tablet contains 20 mg of mianserin hydrochloride.
The tablets also contain:
pregelatinised maize starch
colloidal anhydrous silica
calcium hydrogen phosphate
Opadry White Y-1-7000 (contains colour 171).
Lumin tablets contain trace amounts of sulfites. Lumin tablets are gluten free.
Lumin is supplied by:
Alphapharm Pty Ltd
Level 1, 30 The Bond
30-34 Hickson Road
Millers Point NSW 2000
Australian registration numbers:
Lumin 10 - AUST R 55272
Lumin 20 - AUST R 55273
This leaflet was prepared on
20 December 2019.