Telmisartan and Hydrochlorothiazide
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Micardis Plus.
It does not contain all available information.
It does not take the place of talking to your doctor or pharmacist.
All medicines have benefits and risks. Your doctor has weighed the risks of you taking
this medicine against the benefits it is expected to have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
This leaflet was last updated on the date at the end of this leaflet. More recent
information may be available. The latest Consumer Medicine Information is available
from your pharmacist, doctor, or from www.medicines.org.au and may contain important
information about the medicine and its use of which you should be aware.
Keep this leaflet with the medicine.
You may need to read it again.
What Micardis Plus is used for
Micardis Plus is used to lower high blood pressure (hypertension).
Everyone has blood pressure. This pressure helps your blood move around your body.
Your blood pressure may be different at different times of the day, depending on how
busy or worried you are. You have hypertension (high blood pressure) when your blood
pressure stays higher than is needed, even when you are calm or relaxed.
There are usually no signs of hypertension. The only way of knowing that you have
hypertension is to have your blood pressure checked on a regular basis. If high blood
pressure is not treated, it can lead to serious health problems, including stroke,
heart disease and kidney failure.
How Micardis Plus works
Micardis Plus contains telmisartan and hydrochlorothiazide in one single tablet. These
two active ingredients help to reduce blood pressure in different ways:
Telmisartan belongs to a group of medicines called angiotensin II receptor antagonists.
Angiotensin II is a substance in the body which causes blood vessels to narrow, thus
increasing blood pressure. Telmisartan works by blocking the effect of angiotensin
II. When the effect of angiotensin II is blocked, your blood vessels relax and your
blood pressure goes down.
Hydrochlorothiazide belongs to the group of medicines called diuretics. Diuretics
help to reduce the amount of excess fluid in the body by increasing the amount of
urine produced. They help with lowering blood pressure particularly when used with
other blood pressure lowering medicines.
Your doctor may have prescribed Micardis Plus for another reason.
Ask your doctor if you have any questions about why Micardis Plus has been prescribed
Micardis Plus is not addictive.
This medicine is available only with a doctor's prescription.
Before you take Micardis Plus
When you must not take it
Do not take Micardis Plus if you have an allergy to:
any medicine containing telmisartan or hydrochlorothiazide (the two active ingredients
in Micardis Plus)
other sulfonamide-derived medicines
any of the other ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin.
Do not take Micardis Plus if you have a rare hereditary condition of fructose intolerance.
The maximum recommended daily dose of Micardis Plus contains 169 mg of sorbitol (in
the 40/12.5 mg tablets) and approximately 338 mg of sorbitol (in the 80/12.5 mg and
80/25 mg tablets).
Do not take Micardis Plus if you have a rare hereditary condition of galactose intolerance.
The maximum recommended daily dose of Micardis Plus contains 112 mg of lactose monohydrate
(in the 40/12.5 mg and 80/12.5 mg tablets) and 99 mg of lactose monohydrate (in the
80/25 mg tablets).
Do not take Micardis Plus if you are pregnant.
Like other similar medicines, it may affect your developing baby if you take it during
Do not breast-feed if you are taking Micardis Plus.
It is not known if telmisartan or hydrochlorothiazide, the active ingredients in Micardis
Plus, pass into breast milk and there is a possibility that your baby may be affected.
Do not give Micardis Plus to a child under the age of 18 years.
Safety and effectiveness in children and teenagers up to 18 years of age have not
Do not take Micardis Plus if you have any of the following medical conditions:
severe liver disease
severe kidney disease
cholestasis or biliary obstructive disorders (problem with the flow of bile from the
low potassium levels in the blood
high calcium levels in the blood
diabetes or kidney problems and you are taking aliskiren (a medicine used to treat
high blood pressure).
Do not take Micardis Plus after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking Micardis Plus, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, preservatives
Tell your doctor if you have or have had any of the following medical conditions:
a condition known as primary hyperaldosteronism (raised aldosterone levels, also known
as Conn's syndrome)
recent severe diarrhoea or vomiting
systemic lupus erythematosus (a disease affecting the skin, joints and kidney)
Tell your doctor if you are following a very low salt diet.
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding.
Your doctor can discuss with you the risks and benefits involved.
If you have not told your doctor about any of the above, tell your doctor before you
start taking Micardis Plus.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you get without a prescription from your pharmacy, supermarket or health food
Some medicines and Micardis Plus may interfere with each other. These include:
any other medicines used to treat high blood pressure such as beta-blockers
heart medicines such as digoxin, a medicine used to treat heart failure or antiarrhythmic
lithium, a medicine used to treat certain mental illnesses
other diuretics or fluid tablets, medicines used to help the kidneys get rid of salt
and water by increasing the amount of urine produced
potassium supplements or potassium-containing salt substitutes
medicines or salt substitutes which may increase your potassium levels
amphotericin B, a medicine used to treat fungal infections
penicillin antibiotics used to treat bacterial infections
strong pain killing medicines
medicines for diabetes (oral tablets or capsules or insulin)
powder or granules used to help reduce cholesterol
corticosteroid medicines such as prednisolone, cortisone or ACTH
nonsteroidal anti-inflammatory agents (medicines used to relieve pain, swelling and
other symptoms of inflammation including arthritis)
medicines used to treat gout
calcium supplements or medicines containing calcium
anticholinergic medicines, which can be used to treat Parkinson's disease, relieve
stomach cramps or prevent travel sickness
amantadine, a medicine used to treat Parkinson's disease or to prevent influenza
medicines used to treat cancer (cytotoxic medicines).
These medicines may be affected by Micardis Plus, or may affect how well it works.
Other medicines used to treat high blood pressure may have an additive effect with
Micardis Plus in lowering your blood pressure. You may need different amounts of your
medicines, or you may need to take different medicines.
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while taking Micardis Plus.
How to take Micardis Plus
Follow all directions given to you by your doctor or pharmacist carefully.
They may differ from the information contained in this leaflet.
Your doctor or pharmacist will tell you how many tablets you will need to take each
day. This depends on your condition and whether or not you are taking any other medicines.
If you do not understand the instructions on the label, ask your doctor or pharmacist
How much to take
The usual dose for adults is one Micardis Plus 40/12.5 mg tablet once a day.
If your blood pressure is still too high after 4-8 weeks of starting treatment, your
doctor may increase your dose to one Micardis Plus 80/12.5 mg tablet once a day.
If your blood pressure is still not satisfactorily controlled with Micardis Plus 80/12.5
mg, your doctor may increase your dose to one Micardis Plus 80/25 mg tablet once a
It is important to take Micardis Plus exactly as your doctor or pharmacist has told
How to take it
Swallow the tablet whole with a full glass of water.
When to take it
Take Micardis Plus at about the same time each day, either morning or evening.
Taking it at the same time each day will have the best effect. It will also help you
remember when to take it.
You can take Micardis Plus with or without food.
How long to take it
Continue taking Micardis Plus for as long as your doctor tells you.
Micardis Plus helps control your high blood pressure but does not cure it. It is important
to keep taking Micardis Plus every day even if you feel well.
People who have high blood pressure often feel well and do not notice any signs of
If you forget to take it
If it is almost time for your next dose, skip the dose you missed and take your next
dose when you are meant to. Otherwise, take the dose as soon as you remember, and
then go back to taking it as you would normally.
Do not take a double dose to make up for the dose that you missed.
This may increase the chance of you getting unwanted side effects.
If you are not sure what to do, ask your doctor or pharmacist.
If you have trouble remembering when to take your medicine, ask your pharmacist for
If you take too much (overdose)
Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26)
for advice or go to Emergency at your nearest hospital, if you think that you or anyone
else may have taken too much Micardis Plus.
Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
If you take too much Micardis Plus you may feel dizzy, light-headed or faint. Your
heartbeat may be faster or slower than usual. You may experience dehydration, nausea,
drowsiness and muscle spasm.
While you are taking Micardis Plus
Things you must do
Tell any other doctors, dentists and pharmacists who are treating you that you are
taking Micardis Plus.
If you are about to be started on any new medicine, tell your doctor or pharmacist
that you are taking Micardis Plus.
If you feel that Micardis Plus is not helping your condition, tell your doctor or
Tell your doctor if, for any reason, you have not used Micardis Plus exactly as prescribed.
Otherwise, your doctor may think that it was not effective and change your treatment
Tell your doctor immediately if you become pregnant while taking Micardis Plus.
If you are going to have surgery, tell your doctor, surgeon and anaesthetist that
you are taking Micardis Plus.
Micardis Plus may affect some medicines you receive during surgery.
Tell your doctor if you develop an unexpected abnormal lump, bump, ulcer, sore or
coloured area on the skin (skin lesion) during the treatment.
Treatment with hydrochlorothiazide, particularly long-term use with high doses, may
increase the risk of some types of skin and lip cancer (non-melanoma skin cancer).
Protect your skin from sun exposure and UV rays while taking Micardis Plus.
Things you must not do
Do not take Micardis Plus to treat any other complaints unless your doctor tells you
Do not give this medicine to anyone else, even if they have the same condition as
Do not stop taking Micardis Plus or lower the dosage without checking with your doctor.
Things to be careful of
Be careful when driving or operating machinery until you know how Micardis Plus affects
Like other medicines used to treat high blood pressure, Micardis Plus may cause sleepiness,
dizziness or light-headedness in some people.
If you have any of these symptoms, do not drive, operate machinery or do anything
else that could be dangerous.
You may feel dizzy or light-headed when you begin to take Micardis Plus, especially
if you are also taking a diuretic (or fluid tablet) or if you are dehydrated.
If you feel dizzy or light-headed, and you wish to stand up, you should do so slowly.
Standing up slowly, especially when you get up from a bed or chair, will help your
body get used to the change in position and blood pressure. If this problem continues
or gets worse, talk to your doctor.
If you exercise, or if you sweat, or if the weather is hot, you should drink plenty
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking Micardis Plus.
All medicines can have side effects. Sometimes they are serious, most of the time
they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you:
fainting, dizziness or spinning sensation
a feeling of tension or fullness in the nose, cheeks and behind the eyes, sometimes
with a throbbing ache (sinusitis)
infections of the air passages
shortness of breath or difficulty breathing
abnormal or blurred vision
changes in heart rhythm or increased heart rate
rash or redness or itchiness of skin
dizziness or light-headedness when you stand up (postural hypotension)
stomach pain or discomfort (abdominal pain, dyspepsia, gastritis)
wind or excessive gas in the stomach or bowel
diarrhoea or constipation
pins and needles
sleep disturbances or trouble sleeping
leg pain or cramps in legs
aching muscles or aching joints not caused by exercise or muscle spasms
changes in the levels of potassium or sodium or uric acid in your blood (such changes
are usually detected by a blood test).
Tell your doctor as soon as possible if you experience any side effects during or
after taking Micardis Plus, so that these may be properly treated.
Symptoms such as feeling very thirsty, sleepy, sick or vomiting, a dry mouth, general
weakness, muscle pain or cramps, a very fast heart rate, may mean that the hydrochlorothiazide
part of Micardis Plus is having an excessive effect.
You should tell your doctor if you experience any of these symptoms.
Tell your doctor as soon as possible if you notice any unexpected changes to your
skin, including your lips.
This could be a type of skin or lip cancer (non-melanoma skin cancer).
Tell your doctor immediately or go to Emergency at your nearest hospital if you notice
any of the following:
swelling of the face, lips, mouth, tongue or throat which may cause difficulty in
swallowing or breathing
severe and sudden onset of pinkish, itchy swellings on the skin, also called hives
or nettle rash
developing or worsening of a disease called systemic lupus erythematosus which affects
the skin, joints and kidney.
These are serious side effects. You may need urgent medical attention or hospitalisation.
These side effects are rare.
Tell your doctor or pharmacist if you notice anything else that is making you feel
Other side effects not listed above may also occur in some people.
After taking Micardis Plus
Keep the tablets in the blister strip until it is time to take a dose.
The blister pack protects the tablets from light and moisture.
Keep Micardis Plus in a cool, dry place where the temperature stays below 25°C.
Do not store Micardis Plus or any other medicine in the bathroom or near a sink. Do
not leave it in the car or on a window sill.
Heat and dampness can destroy some medicines.
Keep Micardis Plus where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
If your doctor tells you to stop taking Micardis Plus or the expiry date has passed,
ask your pharmacist what to do with any that is left over.
What it looks like
Micardis Plus is the brand name of your medicine.
Micardis Plus tablets are available in three strengths: 40/12.5 mg, 80/12.5 mg and
80/25 mg tablets.
Micardis Plus 40/12.5 mg tablets are red and white oval shaped two layer tablets.
The white face is marked with the Boehringer Ingelheim logo and 'H4'.
Micardis Plus 80/12.5 mg tablets are red and white oval shaped two layer tablets.
The white face is marked with the Boehringer Ingelheim logo and 'H8'.
Micardis Plus 80/25 mg tablets are yellow and white oval shaped two layer tablets.
The white face is marked with the Boehringer Ingelheim logo and 'H9'.
Micardis Plus tablets are available in blister packs of 7* (sample), 14*, 28, 56*
and 98* tablets.
* Not currently distributed in Australia.
Each Micardis Plus 40/12.5 mg tablet contains 40 mg telmisartan and 12.5 mg hydrochlorothiazide.
Each Micardis Plus 80/12.5 mg tablet contains 80 mg telmisartan and 12.5 mg hydrochlorothiazide.
Each Micardis Plus 80/25 mg tablet contains 80 mg telmisartan and 25 mg hydrochlorothiazide.
The other ingredients found in the tablets are:
iron oxide red CI77491 (in Micardis Plus 40/12.5 mg tablet and Micardis Plus 80/12.5
iron oxide yellow CI77492 (in Micardis Plus 80/25 mg tablets)
sodium starch glycollate type A
Micardis Plus tablets are supplied in Australia by:
Boehringer Ingelheim Pty Limited
ABN 52 000 452 308
® Micardis is a registered trademark of Boehringer Ingelheim
© Boehringer Ingelheim Pty Limited 2019
This Consumer Medicine Information was updated in April 2019.
Australian Registration Numbers
Micardis Plus 40/12.5 mg tablets:
AUST R 82416
Micardis Plus 80/12.5 mg tablets:
AUST R 82418
Micardis Plus 80/25 mg tablets:
AUST R 143761