Consumer Medicine Information (CMI) summary
The
full CMI on the next page has more details. If you are worried about using this medicine,
speak to your doctor or pharmacist.
1. Why am I using Persantin Ampoules?
Persantin Ampoules contain the active ingredient dipyridamole. Persantin Ampoules
are used as a tool in detecting potential problems on how the heart functions in times
of stress.
2. What should I know before I use Persantin Ampoules?
Do not use if you have ever had an allergic reaction to dipyridamole or any of the
ingredients listed at the end of the CMI.
Talk to your doctor if you have any other medical conditions, take any other medicines,
or are pregnant or plan to become pregnant or are breastfeeding.
3. What if I am taking other medicines?
Some medicines may interfere with Persantin Ampoules and affect how it works.
4. How do I use Persantin Ampoules?
Your doctor will decide what dose you will receive, based on your body weight.
Persantin Ampoules are given as an infusion (drip) into your veins, over several minutes.
5. What should I know while using Persantin Ampoules?
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Things you should do
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Remind any doctor, dentist or pharmacist you visit that you are using Persantin.
Tell your doctor if you are pregnant or if you think you may be pregnant or are breast-feeding.
Tell your doctor if you have or have had any of the following medical conditions:
any heart condition or heart disease
asthma, high or low blood pressure
unexplained fainting or mini-stroke
severe muscle disease (myasthenia gravis).
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Things you should not do
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You should not be given this medicine in states of shock or collapse.
You should not be given this medicine if you have any serious heart conditions
You should not be given this medicine if you are pregnant or are breast-feeding
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Looking after your medicine
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Persantin Ampoules will be stored in the pharmacy or ward below 25°C. Each ampoule
can only be used once and unused contents of opened ampoules must be discarded.
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6. Are there any side effects?
Tell your doctor or nurse as soon as possible if you experience any side effects during
or after treatment with Persantin Ampoules, so that these may be properly treated.
These side effects include:
angina
heart attack, heart failure
stroke or mini-stroke
changes in heart beat (faster, slower or irregular).
Active ingredient:
dipyridamole
Full Consumer Medicine Information (CMI)
This leaflet provides important information about using Persantin Ampoules. You should also speak to your doctor or pharmacist if you would like further information
or if you have any concerns or questions about using Persantin Ampoules.
Where to find information in this leaflet:
1. Why am I using Persantin Ampoules?
Persantin Ampoules contains the active ingredient dipyridamole. Persantin is a heart medicine. Persantin increases blood flow to the heart by causing
the blood-supplying arteries to widen.
Persantin Ampoules are used as a tool in detecting potential problems on how the heart
functions in times of stress. It is therefore useful in predicting the likelihood
of the risks of heart disease.
2. What should I know before I am given Persantin Ampoules?
Warnings
You should not be given Persantin Ampoules if:
you are allergic to dipyridamole, or any of the ingredients listed at the end of this
leaflet.
Always check the ingredients to make sure you can use this medicine.
you are in states of shock or collapse.
you have any serious heart conditions such as:
heart attack or failure
angina
abnormal changes in rhythm or rate of the heart beat (irregular, fast or slow)
heart valve problems
blockage of the lung artery
inflammation of the heart muscle (myocarditis), inner lining of the heart (endocarditis)
or membrane enclosing the heart (pericarditis)
tear in the wall of the aorta (major artery in the body).
Check with your doctor if you:
have or have had any of the following medical conditions:
any heart condition or heart disease
asthma
high or low blood pressure
unexplained fainting or mini-stroke
severe muscle disease (myasthenia gravis).
take any medicines for any other condition
During treatment, you may be at risk of developing certain side effects. It is important
you understand these risks and how to monitor for them. See additional information
under Section
6. Are there any side effects?
Pregnancy and breastfeeding
You should not be given this medicine if you are pregnant or are breast-feeding.
It may affect your developing baby if you have it during pregnancy.
The active ingredient in Persantin passes into breast milk.
Children and adolescents
This medicine should not be given to a child.
There is limited information about the use of Persantin Ampoules in children.
3. What if I am taking other medicines?
Tell your doctor or pharmacist if you are taking any other medicines, including any
medicines, vitamins or supplements that you buy without a prescription from your pharmacy,
supermarket or health food shop.
Some medicines may interfere with Persantin and affect how it works.
In particular tell your doctor if you are taking:
aspirin
any medicine containing dipyridamole (e.g. Persantin® SR or Asasantin® SR capsules)
medicines used to thin your blood such as warfarin
medicines used to treat asthma, bronchitis and emphysema such as theophylline
medicines used to treat high blood pressure
neostigmine, distigmine and related medicines (used, for example, in the treatment
of myasthenia gravis)
medicines used to treat rapid heart rhythm such as adenosine
You may need different amounts of your medicines, or you may need to take different
medicines.
Avoid drinks such as tea, coffee and cola (which contain caffeine) for 24 hours before
treatment with Persantin Ampoules.
This is because the caffeine in these drinks can decrease the effects of the medicine..
Check with your doctor or pharmacist if you are not sure about what medicines, vitamins
or supplements you are taking and if these affect Persantin Ampoules.
4. How am I given Persantin Ampoules?
How much is given
Persantin Ampoules are given as an infusion (drip) into your veins, over several minutes.
Your doctor will decide what dose you will receive, based on your body weight.
PERFUSION IMAGING:
The recommended dose is 0.14 mg/kg/min (0.56 mg/kg total) infused over 4 minutes.
STRESS ECHO TESTING:
The recommended dose is 0.56 mg/kg over a 4 minute period, followed by 4 minutes of
no dose, and if echo monitoring shows no changes, by an additional 0.28 mg/kg over
2 minutes. The cumulative dosage is 0.84 mg/kg over 10 minutes. The protocol may also
be given in 6 minutes.
If you are given too much Persantin Ampoules
As Persantin Ampoules are given to you under the supervision of your doctor, it is
very unlikely that you will receive too much.
Symptoms of an overdose may include feeling warm, flushing, sweating, restlessness,
weakness and dizziness. There may be effects on the heart and circulation causing
chest pain, an increase in pulse rate and a drop in blood pressure.
Tell your doctor or nurse immediately if you experience any signs of overdose, or,
if you are not in hospital, go to the Emergency department at your nearest hospital.
You may need urgent medical attention.
5. What should I know while using Persantin Ampoules?
Things you must do
Tell your doctor if you are pregnant or if you think you may be pregnant or are breast-feeding
Call your doctor straight away if you:
do not feel well while you are being given Persantin Ampoules.
Remind any doctor, dentist or pharmacist you visit that you are using Persantin Ampoules.
Looking after your medicine
Persantin Ampoules will be stored in the pharmacy or ward below 25°C. Each ampoule
can only be used once and unused contents of opened ampoules must be discarded.
Getting rid of any unwanted medicine
If you no longer need to use this medicine or it is out of date, take it to any pharmacy
for safe disposal.
Persantin must not be used after the expiry date printed on the pack or ampoule or
if the packaging is torn or shows signs of tampering..
6. Are there any side effects?
All medicines can have side effects. If you do experience any side effects, most of
them are minor and temporary. However, some side effects may need medical attention.
See the information below and, if you need to, ask your doctor or pharmacist if you
have any further questions about side effects.
Some of the side effects of Persantin are related to the way the medicine works on
the heart and circulation. Persantin causes widening of the arteries and if these
widen too much there may be a fall in blood pressure which may cause problems with
the blood circulation.
Less serious side effects
Serious side effects
Tell your doctor or pharmacist if you notice anything else that may be making you
feel unwell.
Other side effects not listed here may occur in some people.
Reporting side effects
After you have received medical advice for any side effects you experience, you can
report side effects to the Therapeutic Goods Administration online at
www.tga.gov.au/reporting-problems . By reporting side effects, you can help provide more information on the safety of
this medicine.
7. Product details
This medicine is only available with a doctor's prescription.
What Persantin Ampoules contain
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Active ingredient
(main ingredient)
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Dipyridamole 10 mg
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Other ingredients
(inactive ingredients)
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Tartaric acid
Macrogol 600
Hydrochloric acid
Water for injections
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Potential allergens
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-
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Do not take this medicine if you are allergic to any of these ingredients.
What Persantin Ampoules looks like
Persantin Ampoules are a clear, yellow solution. It comes in a glass ampoules. (AUST
R 17934).
Who distributes Persantin Ampoules
Persantin Ampoules are supplied in Australia by:
Clinect Pty Ltd
120 - 132 Atlantic Drive
Keysborough VIC 3173
Australia
Telephone: 1800 899 005
This leaflet was prepared in January 2021.