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Contracted research
Screening of drug candidates and other compounds on human and animal muscle organs, including 3D human skeletal muscle, iPSC-derived systems, and neuromuscular junction models. We provide a comprehensive assessment of muscle morphology and function, delivering high-quality data on toxicity and efficacy.
Research and development
Development of bespoke assays to enable drug discovery against specific modalities, including disease, exercise, injury, and rehabilitation.
Image Credit: Myomaker Bio
Muscle organs
- 3D human-derived muscle organs
- Designed for bespoke preclinical assays
- Organs are cultured in multi-well plate format
Validation of pharmaceutical agents including:
- Barium Chloride
- Leucine
- d-tubocurarine
- Insulin
- Resolvin E1 (RvE1)
- Testosterone
Organ cell types:
- Human: Primary, cell line and iPSC
- Animal
- Rodent (rat, mice)
- Small mammal (rabbit)
- Other: Zebra Fish
Myomaker organ 1: Chemical injury has been modelled using barium chloride, cardiotoxin and tubocurarine. Barium chloride ablates muscle fibres (left), this injury is followed by regeneration. Image Credit: Myomaker Bio
Neuromuscular organs
- Skeletal muscle organ with functional neuromuscular junctions
- Demonstrated by pre- and post synaptic colocalization
Image Credit: Myomaker Bio
Myomaker organ 2: Spontaneous twitch in muscle organs with iPSC motor neurons (red) and without (blue). Inhibition of acetylcholine receptor in spontaneously contracting neuromuscular tissues demonstrated with the addition of d-Tubocurarine. Image Credit: Myomaker Bio
Model outputs
- Morphology (cryosectioning, immunocytochemistry)
- Functional analysis (evoked and spontaneous contraction)
- Gene and protein expression (inc. RNAseq)
- Media analysis (inc. creatine kinase, lactate)
Image Credit: Myomaker Bio
Model development
Muscle organs can be combined with other human cells (including disease modalities) to generate multifunctional organs. Myomaker Bio has extensive experience in the development of novel models for understanding muscle biology.
Models developed:
- Mechanical and electrical loading
- Chemical Injury
- Shockwave Injury
- Metabolic Disease
Myomaker Organ 3: Sensory innervated muscle. Image Credit: Myomaker Bio
Myomaker Organ 4: Vascularised Muscle. Image Credit: Myomaker Bio
About Myomaker Bio
Myomaker Bio is a spinout from Loughborough University and a recognized leader in muscle biology. The team brings decades of scientific, managerial, and leadership experience, with deep expertise in muscle organ research. Myomaker Bio provides comprehensive support across all stages of drug discovery and development where muscle testing is required.
About ELRIG (UK) Ltd.
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Last Updated: Dec 1, 2025